REM sleep disorder following general anesthesia in rats

Lazic, Katarina; Petrović, Jelena; Ciric, Jelena; Kalauzi, Aleksandar; Saponjic, Jasna

doi:10.1016/j.physbeh.2016.10.013

Cited by 13 publications

(39 citation statements)

References 30 publications

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“…The surgical procedures employed for the EEG and EMG electrode implantation for chronic sleep recording and bilateral PPT lesion have been described previously [16][17][18][19][20][21][22][23][24], and are outlined below.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…The IBO (Sigma; pH = 7.4) concentration was chosen on the basis of previous studies [16,18,20,23,26]. The microinfusions were introduced at a volume of 100 nl, using a single, 60 s pulse.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…The analysis of the recorded signals was conducted using software developed in MATLAB 6.5 [16,[18][19][20][21][22][23], and upgraded to MATLAB R2011a. We applied Fourier analysis to signals acquired throughout 6 h (2160 10 s Fourier epochs), and each 10 s epoch was differentiated, on the basis of EEG and EMG, as Wake, NREM, or REM sleep state (Figure 1).…”

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

“…We applied Fourier analysis to signals acquired throughout 6 h (2160 10 s Fourier epochs), and each 10 s epoch was differentiated, on the basis of EEG and EMG, as Wake, NREM, or REM sleep state (Figure 1). The differentiation of all Wake/NREM/REM sleep epochs was improved by using the logarithmic values of the quantities on both EEG and EMG axes, and was finally achieved using the two cluster K means algorithm [16,[18][19][20][21][22][23].…”

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

“…To analyze REM sleep EEG microstructure, we calculated the group probability density distributions of all conventional EEG frequency bands relative amplitudes over 6 h, using the Probability Density Estimate (PDE) routine supplied by MATLAB R2011a [16,[18][19][20][22][23][24].…”

Section: Sleep Recording and Data Analysismentioning

confidence: 99%

See 4 more Smart Citations

Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy

Ciric¹,

Lazic²,

Petrović³

et al. 2017

Transl Brain Rhythmicity

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Rhythmic oscillations of neuronal populations, generated by different mechanisms, are present at several levels of the central nervous system and serve many important physiological or reflect pathological functions. Understanding the role of brain oscillations as possible biomarkers of brain function and plasticity is still a challenge, and despite extensive research, their role is still not well established.We recently demonstrated that the hallmarks of earlier aging onset during impaired thalamo-cortical cholinergic innervation (in a rat model of Parkinson's disease cholinopathy) were consistently expressed, from 3 and one half to 5 and one half months of age, through increased electroencephalographic (EEG) sigma activity amplitude during rapid eye movement (REM) sleep, as a unique aging induced REM sleep phenomenon. In addition, there was altered motor cortical drive during non-rapid-eye-movement (NREM) and REM sleep.In order to explain this new aging-induced REM sleep phenomenon, we analyzed possible differences between control REM sleep spindle activity and REM sleep spindle activity at the onset of REM sleep "enriched" with sigma activity (at 4 and one half months of age), following bilateral pedunculopontine tegmental nucleus (PPT) cholinergic neuronal loss in the rat. We analzyed differences in spindle density, duration, and frequency.We demonstrated in young adult Wistar rats with the severely impaired PPT cholinergic innervation the alterations in sleep spindle dynamics and pattern during REM sleep in the motor cortex as the earliest biomarkers for the onset of their altered aging processes.

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Section: Surgical Proceduresmentioning

confidence: 99%

“…The IBO (Sigma; pH = 7.4) concentration was chosen on the basis of previous studies [16,18,20,23,26]. The microinfusions were introduced at a volume of 100 nl, using a single, 60 s pulse.…”

Section: Surgical Proceduresmentioning

confidence: 99%