REM sleep deprivation impairs retrieval, but not reconsolidation, of methamphetamine reward memory in male rats

Shahveisi, Kaveh; Khazaie, Habibolah; Farnia, Vahid; Khodamoradi, Mehdi

doi:10.1016/j.pbb.2019.172759

Cited by 12 publications

(4 citation statements)

References 83 publications

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“…There is much evidence suggesting that the consolidated memory can, at least partially, be modified, updated, or eliminated following retrieval and the subsequent reconsolidation processes (Shahveisi et al, 2019). In addition, CPP provides a convenient paradigm for memory reconsolidation research (Reichelt and Lee, 2013).…”

Section: Discussionmentioning

confidence: 99%

Postretrieval Microinjection of Baclofen Into the Agranular Insular Cortex Inhibits Morphine-Induced CPP by Disrupting Reconsolidation

Sun

Chang

et al. 2020

Front. Pharmacol.

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Environmental cues associated with drug abuse are powerful mediators of drug craving and relapse in substance-abuse disorders. Consequently, attenuating the strength of cuedrug memories could reduce the number of factors that cause drug craving and relapse. Interestingly, impairing cue-drug memory reconsolidation is a generally accepted strategy aimed at reducing the intensity of cues that trigger drug-seeking and drug-taking behaviors. In addition, the agranular insular cortex (AI) is an important component of the neural circuits underlying drug-related memory reconsolidation. GABA B receptors (GABA B Rs) are potential targets for the treatment of addiction, and baclofen (BLF) is the only prototypical GABA B agonist available for application in clinical addiction treatment. Furthermore, DFosB is considered a biomarker for the evaluation of potential therapeutic interventions for addiction. Here, we used the morphine-induced conditioned place preference (CPP) paradigm to investigate whether postretrieval microinjections of BLF into the AI could affect reconsolidation of drug-reward memory, reinstatement of CPP, and the level of DFosB in mice. Our results showed that BLF infused into the AI immediately following morphine CPP memory retrieval, but not 6 h postretrieval or following nonretrieval, could eliminate the expression of a morphine CPP memory. This effect persisted in a morphine-priming-induced reinstatement test, suggesting that BLF in the AI was capable of preventing the reconsolidation of the morphine CPP memory. Our results also showed that the elimination of morphine CPP memory was associated with reduced morphine-associated DFosB expression in the longer term. Taken together, the results of our research provide evidence to support that GABA B Rs in the AI have an important role in drug-cue memory reconsolidation and further our understanding of the role of the AI in drug-related learning and memory.

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Section: Discussionmentioning

confidence: 99%

Postretrieval Microinjection of Baclofen Into the Agranular Insular Cortex Inhibits Morphine-Induced CPP by Disrupting Reconsolidation

Sun

Chang

et al. 2020

Front. Pharmacol.

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“…For REM-SD, the modified multiple platform method was used [ 10 , 16 ]. We randomly divided rats into control (non-SD), SD, and PG-treated SD groups.…”

Section: Methodsmentioning

confidence: 99%

Antimania-Like Effect of Panax ginseng Regulating the Glutamatergic Neurotransmission in REM-Sleep Deprivation Rats

Leem

Kim

2020

BioMed Research International

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Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male rats were sleep-deprived for 48 h, and PG (200 mg/kg) was administered for 4 days, from 2 days prior to the start of SD to the end date of SD. The elevated plus maze (EPM) test showed that PG alleviated the increased frequency of entries into and spent time within open arms by SD. In order to investigate the molecular mechanism on this effect of PG, we assessed differentially expressed genes (DEGs) in the prefrontal cortex of PG-treated SD rats using RNA sequencing (RNA-seq) and performed gene-enrichment analysis for DEGs. The gene-enrichment analysis showed that PG most prominently affected the glutamatergic synapse pathway. Among the glutamatergic synapse pathway genes, particularly, PG enhanced the expressions of glutamate transporter Slc1a3 and Slc1a2 reduced in SD rats. Moreover, we found that PG could inhibit the SD-induced phosphorylation of the NR2A subunit of the NMDA receptor. These results suggested that PG might have a therapeutic effect against the manic-like behaviors, regulating the glutamatergic neurotransmission.

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“…As a powerful stress-factor, sleep deprivation can lead to impaired cognitive function, decreased ability to correctly set tasks and their high speed and accuracy of execution, which is mediated by pronounced changes in brain plasticity [68,69]. Early studies point to sleep's essential role in short-term memory reorganization mechanisms into the long-term once [66,70].…”

Section: Discussionmentioning

confidence: 99%

Features of age-related response to sleep deprivation: in vivo experimental studies

Novozhilova

Mishchenko

Kondakova

et al. 2021

Aging

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Insomnia is currently considered one of the potential triggers of accelerated aging. The frequency of registered sleep-wake cycle complaints increases with age and correlates with the quality of life of elderly people. Nevertheless, whether insomnia is actually an age-associated process or whether it acts as an independent stress-factor that activates pathological processes, remains controversial. In this study, we analyzed the effects of long-term sleep deprivation modeling on the locomotor and orienting-exploratory activity, spatial learning abilities and working memory of C57BL/6 female mice of different ages. We also evaluated the modeled stress influence on morphological changes in brain tissue, the functional activity of the mitochondrial apparatus of nerve cells, and the level of DNA methylation and mRNA expression levels of the transcription factor HIF-1α (Hif1) and age-associated molecular marker PLIN2. Our findings point to the age-related adaptive capacity of female mice to the long-term sleep deprivation influence. For young (1.5 months) mice, the modeled sleep deprivation acts as a stress factor leading to weight loss against the background of increased food intake, the activation of animals' locomotor and exploratory activity, their mnestic functions, and molecular and cellular adaptive processes ensuring animal resistance both to stress and risk of accelerated aging development. Sleep deprivation in adult (7-9 months) mice is accompanied by an increase in body weight against the background of active food intake, increased locomotor and exploratory activity, gross disturbances in mnestic functions, and decreased adaptive capacity of brain cells, that potentially increasing the risk of pathological reactions and neurodegenerative processes. AGINGTable 1. Parameters of behavioral reactions of female C57BL/6 mice in the "Open field" test day after the end of sleep deprivation. (A) Young mice (1.5 months). Experimental groups Average speed crossing the arena, squares /s Number of squares passed in the arena Time in the arena center, s Number of peeks in holes Periphery Center Intact 0.26±0.03 57.6±6.0 20.0±4.3 41.3±7.14 27.33±4.33 Control 0.28±0.02 66.0±6.27 22.8±3.1 42.4±5.52 26.3±2.59 SD 0.45±0.02*# §۷ 109.4±7.36*# §۷ 27.0±3.26 38.4±4.35 § 42.1±4.08*# §۷ (B) Adult mice (7-9 months). Experimental groups Average speed crossing the arena, squares /s Number of squares passed in the arena Time in the arena center, s Number of peeks in holes Periphery Center Intact 0.29±0.

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REM sleep deprivation impairs retrieval, but not reconsolidation, of methamphetamine reward memory in male rats

Cited by 12 publications

References 83 publications

Postretrieval Microinjection of Baclofen Into the Agranular Insular Cortex Inhibits Morphine-Induced CPP by Disrupting Reconsolidation

Postretrieval Microinjection of Baclofen Into the Agranular Insular Cortex Inhibits Morphine-Induced CPP by Disrupting Reconsolidation

Antimania-Like Effect of Panax ginseng Regulating the Glutamatergic Neurotransmission in REM-Sleep Deprivation Rats

Features of age-related response to sleep deprivation: in vivo experimental studies

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