REM sleep Behaviour Disorder

Ferini‐Strambi, Luigi; Rinaldi, Fabrizio; Giora, Enrico; Marelli, Sara; Galbiati, Andrea

doi:10.1016/j.parkreldis.2015.09.002

Cited by 12 publications

(4 citation statements)

References 34 publications

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“…[1][2][3] Synucleinopathies were often associated with symptoms of autonomic dysfunction, such as impaired blood pressure control and reduced heart rate variability. 4,5 Consistently, individuals with idiopathic RBD experienced worse autonomic function, including cardiovascular, gastrointestinal, and urinary domains, relative to control participants. 6,7 The autonomic nervous system may have a role in the prepathologic state or contribute to the precipitating factors of the acute phase of stroke, such as atherosclerosis and sympathetic hyperactivity.…”

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confidence: 82%

Probable REM sleep behavior disorder and risk of stroke

Pavlova

Liu

et al. 2017

Neurology

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Objective: To examine whether probable REM sleep behavior disorder (pRBD) was associated with increased risk of developing stroke in a community-based cohort. Methods:The study included 12,003 participants (mean age 54.0 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury at baseline (2012). We determined pRBD using a validated REM sleep behavior disorder (RBD) questionnaire in 2012. Incident stroke cases were confirmed by review of medical records. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of stroke according to pRBD status, adjusting for several sleep measures (i.e., insomnia, daytime sleepiness, sleep duration, snoring, and use of hypnotics) and other potential confounders.Results: During 3 years of follow-up, we documented 159 incident stroke cases. Relative to participants without pRBD at the baseline, those with pRBD had a 157% higher risk (95% CI 59%-313%) of developing stroke. Presence of pRBD was associated with increased risk of both stroke types-the adjusted HR was 1.93 (95% CI 1.07-3.46) for ischemic stroke and 6.61 (95% CI 2.27-19.27) for hemorrhagic stroke.Conclusions: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association. Neurology ® 2017;88:1849-1855 GLOSSARY AIS 5 Athens Insomnia Scale; BMI 5 body mass index; CI 5 confidence interval; ESS 5 Epworth Sleepiness Scale; HDL-C 5 high-density lipoprotein cholesterol; HR 5 hazard ratio; ICD-10 5 International Classification of Diseases-10; LDL-C 5 lowdensity lipoprotein cholesterol; OR 5 odds ratio; OSA 5 obstructive sleep apnea; PD 5 Parkinson disease; pRBD 5 probable REM sleep behavior disorder; RBD 5 REM sleep behavior disorder; RBDQ-HK 5 RBD questionnaire-Hong Kong; RMB 5 renminbi.REM sleep behavior disorder (RBD) is associated with synucleinopathies, and a large proportion of individuals with RBD may already have or later develop Parkinson disease (PD), dementia with Lewy bodies, or multiple system atrophy. [1][2][3] Synucleinopathies were often associated with symptoms of autonomic dysfunction, such as impaired blood pressure control and reduced heart rate variability. 4,5 Consistently, individuals with idiopathic RBD experienced worse autonomic function, including cardiovascular, gastrointestinal, and urinary domains, relative to control participants. 6,7 The autonomic nervous system may have a role in the prepathologic state or contribute to the precipitating factors of the acute phase of stroke, such as atherosclerosis and sympathetic hyperactivity. 8 Some case reports suggested that stroke may cause RBD. 9-11 In a previous cross-sectional study, we also found that individuals with probable RBD (pRBD) had higher odds of several concurrent stroke risk factors, such as diabetes and hyperlipidemia. 12 However, whether RBD predicts subsequ...

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confidence: 82%

Probable REM sleep behavior disorder and risk of stroke

Pavlova

Liu

et al. 2017

Neurology

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“…Since Ansari and Johnson (1) first reported that olfactory dysfunction (OD) occurs in Parkinson's disease (PD), OD has been evaluated using tests of odor identification, odor discrimination, odor-threshold detection and electrophysiology (2)(3)(4). OD is not PD-specific and is prevalent in aging and other diseases, particularly in neurodegenerative disorders such as Alzheimer's disease, Huntington's disease, and rapid-eye-movement sleep-behavior disorder (5)(6)(7)(8)(9)(10)(11)(12). OD can severely impact the quality of life, affecting interpersonal and eating habits, patient safety, and nutritional intake (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Olfactory Dysfunction in Familial and Sporadic Parkinson's Disease

Chase

Μarkopoulou

2020

Front. Neurol.

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This minireview discusses our current understanding of the olfactory dysfunction that is frequently observed in sporadic and familial forms of Parkinson's disease and parkinsonian syndromes. We review the salient characteristics of olfactory dysfunction in these conditions, discussing its prevalence and characteristics, how neuronal processes and circuits are altered in Parkinson's disease, and what is assessed by clinically used measures of olfactory function. We highlight how studies of monogenic Parkinson's disease and investigations in ethnically diverse populations have contributed to understanding the mechanisms underlying olfactory dysfunction. Furthermore, we discuss how imaging and system-level approaches have been used to understand the pathogenesis of olfactory dysfunction. We discuss the challenging, remaining gaps in understanding the basis of olfactory dysfunction in neurodegeneration. We propose that insights could be obtained by following longitudinal cohorts with familial forms of Parkinson's disease using a combination of approaches: a multifaceted longitudinal assessment of olfactory function during disease progression is essential to identify not only how dysfunction arises, but also to address its relationship to motor and non-motor Parkinson's disease symptoms. An assessment of cohorts having monogenic forms of Parkinson's disease, available within the Genetic Epidemiology of Parkinson's Disease (GEoPD), as well as other international consortia, will have heuristic value in addressing the complexity of olfactory dysfunction in the context of the neurodegenerative process. This will inform our understanding of Parkinson's disease as a multisystem disorder and facilitate the more effective use of olfactory dysfunction assessment in identifying prodromal Parkinson's disease and understanding disease progression.

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“…Insomnia kronis adalah yang paling umum, dengan hampir 30% lansia yang mengalaminya. (6,7) Insomnia memiliki banyak faktor penyebab dan cenderung kompleks. Saat ini, banyak model yang ada mengenai etiologi dan patofisiologi, yaitu kronisitas (akut, sementara, kronis), tipe (psikofisiologis, karena penyakit medis/psikiatrik, atau idiopatik), dan subtipe (yaitu, awal, tengah, atau akhir).…”

Section: Pendahuluanunclassified

Insomnia pada Lansia: Tantangan dalam Mendiagnosis dan Pemberian Perawatan

Fatma,

Sunarti

2023

JK-RISK

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Perubahan pola tidur pada usia lanjut sering terjadi, bisa sebagai proses fisiologis atau merupakan bagian dari penyakit kronis tertentu. Insomnia adalah salah satu gangguan yang paling banyak dikeluhkan oleh pasien usia lanjut, dan dipengaruhi oleh beberapa faktor seperti perubahan fisiologis, kebiasaan tidur, adanya penyakit – penyakit komorbid, juga bisa karena efek samping obat – obatan yang dikonsumsi. Untuk itu diperlukan skrining tersendiri agar bisa melakukan penilaian klinis komprehensif pada pasien usia lanjut seperti gangguan tidur primer, penyakit komorbid, gangguan mental seperti depresi dan cemas. Penatalaksanaan insomnia ini merupakan tantangan tersendiri dalam diagnosis dan terapi karena dibutuhkan perawatan komprehensif meliputi perubahan gaya hidup, kontrol penyakit komorbid, dan juga manajemen efek samping obat, sehingga nantinya bisa ditentukan terapi yang paling tepat dan efektifitas obat yang optimal.

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REM sleep Behaviour Disorder

Cited by 12 publications

References 34 publications

Probable REM sleep behavior disorder and risk of stroke

Probable REM sleep behavior disorder and risk of stroke

Olfactory Dysfunction in Familial and Sporadic Parkinson's Disease

Insomnia pada Lansia: Tantangan dalam Mendiagnosis dan Pemberian Perawatan

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