REM sleep behaviour disorder in Hong Kong Chinese: clinical outcome and gender comparison

Wing, Yun Kwok; Lam, Siu Ping; Li, Shirley Xin; Yu, Manda; Fong, SW; Tsoh, Joshua; Ho, Crover Kwok Wah; Lam, Venny

doi:10.1136/jnnp.2008.155374

Cited by 95 publications

(81 citation statements)

References 7 publications

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“…This suggested that the RBDQ-Beijing is capable of increasing the accuracy rate of distinguishing RBD from OSAS and other sleep disorders, and it might be a better preliminary diagnostic tool for RBD. OSAS has been reported to be highly prevalent in RBD patients (Olson et al 2000;Wing et al 2008). Five patients with vPSG-confirmed RBD were assigned to the predicted non-RBD group at a cut-off level of 28/29 for the RBDQ-Beijing, more than it would be the case using a cut-off value of 18/19 for the simplified Mandarin version of RBDQ-HK, but the number of patients with RBD complicated OSAS was not increased (Fig.…”

Section: Discussionmentioning

confidence: 93%

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Chang

Zhan

et al. 2014

Tohoku J. Exp. Med.

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REM sleep behavior disorder (RBD) is one type of parasomnia characterized by nocturnal complex motor activity associated with dream mentation. Growing evidence has indicated that RBD is a preclinical stage of neurodegenerative diseases. Therefore screening RBD patient is becoming important. The RBD Questionnaire-Hong Kong (RBDQ-HK) is an effective questionnaire to screen RBD patients. However, it is hard to distinguish RBD with the questionnaire from severe OSAS patients, who could mimic some symptoms of RBD patients. Therefore, we made RBDQ-Beijing by adding two screening questions for OSAS into original RBDQ-HK, including habitual loud snoring and witnessed apnea during sleep. To validate and compare these two questionnaires, 224 subjects were enrolled and screened with these questionnaires, and consequently analyzed with video-polysomnography. Receiver-operator characteristics curve analysis was conducted to attain the best cut-off values of the RBDQ-HK and RBDQ-Beijing. For the RBDQ-HK, the sensitivity was 97.1% and the specificity was 83.2%. More than half of misclassified RBD patients were proved to be severe OSAS patients. For the RBDQ-Beijing, the sensitivity was 95.8% and specificity was 94.3%, indicating that our questionnaire is able to distinguish RBD from severe OSAS patients. In conclusion, RBDQ-Beijing is of help to improve the specificity in RBD screening without excluding the patients with RBD combined OSAS. Therefore the RBDQ-Beijing may be a better screening and preliminary diagnostic tool for RBD than the RBDQ-HK. Moreover, the RBDQ-Beijing would be important for early diagnosis of neurodegenerative diseases and for prevention of injuries to the patient or the patient's bed partner.

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Section: Discussionmentioning

confidence: 93%

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Chang

Zhan

et al. 2014

Tohoku J. Exp. Med.

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“…14 As seen in the typical RBD cases, nightmares are a consistent and dominating feature that may act as an emotional drive for dream enactment. 1,15 Changes in dream content with more vivid and intense dreams and nightmares have been reported among subjects taking serotonergic antidepressants. [16][17][18] In our study, there was a parallel diminution of clinical RBD symptoms and severity of nightmares and dream enactments upon amendment of the antidepressant regimen.…”

mentioning

confidence: 99%

REM Sleep Behavior Disorder in Psychiatric Populations

Lam¹,

Zhang²,

Tsoh³

et al. 2010

J. Clin. Psychiatry

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To the Editor: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a loss of REMrelated muscle atonia and abnormal motor activities during REM sleep with consequent sleep-related injuries. 1,2 It has been increasingly reported among psychiatric populations and has a potential association with use of psychotropics, particularly selective serotonin reuptake inhibitor (SSRI), tricyclic, and serotonin and noradrenergic reuptake inhibitor (SNRI) antidepressants. [3][4][5][6][7][8] A previous case report 5 found that cessation of SSRI treatment did not result in complete resolution of clinical RBD symptoms and polysomnographic (PSG) abnormalities. Our recent clinical epidemiologic study 8 found that 3.8% of psychiatric outpatients might have RBD features over the past year. The prevalence is 10 times more common than that of the typical RBD in the elderly general population. 9 In addition, the RBD features could result in sleep-related injuries and violence, with potential medicolegal repercussions. 8,10 In the current study, we conducted a comprehensive evaluation of clinical and PSG features as well as follow-up response to an open intervention of antidepressant regimen modification.Method. Fifteen depressed subjects with concurrent antidepressant treatment and features suggestive of RBD were included in this case series, which spans from December 2006 to March 2009. They were interviewed by experienced psychiatrists and neurologists for a thorough clinical evaluation, which included a semistructured psychiatric interview and physical examination with Hoehn and Yahr staging for parkinsonism. 11 They also underwent videopolysomnographic assessments at baseline and follow-up.Modification of their current antidepressant regimen was suggested to all subjects. Bupropion was offered as the treatment of choice in this open intervention, as it has rarely been associated

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Section: Epidemiologie Der Rem-schlaf-verhaltensstörungunclassified

“…Es besteht ein signifikant häufigeres Auftreten bei Männern mit einem Verhältnis von etwa 9:1 (Män-ner: Frauen) [9,10]. Das Hauptmanifestationsalter liegt zwischen 40 und 70 Jahren [10]. In Einzelfallbeschreibungen sind auch jüngere Patienten, die an einer iRBD erkrankt sind, beschrieben worden [11,12,13].…”

Section: Epidemiologie Der Rem-schlaf-verhaltensstörungunclassified

Genetische Aspekte der REM-Schlaf-Verhaltensstörung

Young

2014

Somnologie

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REM sleep behaviour disorder in Hong Kong Chinese: clinical outcome and gender comparison

Cited by 95 publications

References 7 publications

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

Validation of the Beijing Version of the REM Sleep Behavior Disorder Questionnaire (RBDQ-Beijing) in a Mainland Chinese Cohort

REM Sleep Behavior Disorder in Psychiatric Populations

Genetische Aspekte der REM-Schlaf-Verhaltensstörung

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