REM sleep behavior disorder: Mimics and variants

Antelmi, Elena; Lippolis, Marianna; Biscarini, Francesco; Tinazzi, Michèle; Plazzi, Giuseppe

doi:10.1016/j.smrv.2021.101515

Cited by 32 publications

(27 citation statements)

References 106 publications

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“…Sleep abnormalities connected with this entity include insomnia affecting sleep onset and fragmented sleep followed by excessive daytime sleepiness, vocalizations, abnormal limb movements, jerks, snoring, sleep apnea and stridor during sleep ( 1 , 36 ) Polysomnography with synchronized audiovisual recording is crucial during anti-IgLON5 diagnosis. Sleep pattern characteristic for the disease were described as “undifferentiated-NREM (UN-NREM) and poorly-structured N2 (P-SN2)” ( 37 ). Diffuse irregular theta waves with increased EMG activity and vocalization occur in UN-NREM phase whereas in P-SN2 “occasional K-complexes or sleep spindles associated with EMG activation” and motor behavior are observed ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…Sleep pattern characteristic for the disease were described as “undifferentiated-NREM (UN-NREM) and poorly-structured N2 (P-SN2)” ( 37 ). Diffuse irregular theta waves with increased EMG activity and vocalization occur in UN-NREM phase whereas in P-SN2 “occasional K-complexes or sleep spindles associated with EMG activation” and motor behavior are observed ( 37 ). It appears that anti-IgLON5 has a distinctive sleep disorder pattern which is unique to this disease.…”

Section: Discussionmentioning

confidence: 99%

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Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives

et al. 2022

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Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical practitioners and scientists. The aim of this review is to summarize the current knowledge concerning anti-IgLON5 disease; mechanisms underlying its cause, symptomatology, clinical progression, differential diagnosis and treatment, which could be helpful in clinical practice and future research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives

et al. 2022

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“…A definite diagnosis of abnormal behaviors during sleep in Patient 4 was difficult, since we were unable to obtain vPSG data. The differential diagnosis of parasomnia includes hypoglycemia and epilepsy ( 20 ). Patients with insulinoma who present with abnormal nocturnal behavior and injury during sleep, resembling RBD, have been reported ( 21 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Effective Treatment of Adult Parasomnias with Keishikaryukotsuboreito in Four Cases

et al. 2022

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Parasomnias are undesirable behaviors or experiences during sleep that manifest clinically as abnormal behavior, emotions, and nightmares. We herein report four elderly parasomnia patients who were successfully treated for abnormal nocturnal behaviors, including rapid eye movement (REM) sleep behavior disorders, with Keishikaryukotsuboreito (KRB), a Japanese traditional herbal medicine. KRB resolved nocturnal violent behaviors and sleep walking without any adverse effects. In one patient, occipital dominant spike-wave complexes induced by 3-Hz photic stimulation were reduced after KRB treatment, suggesting that KRB has inhibitory effects on brain irritability. KRB may represent a safe therapeutic option for treating parasomnias in the elderly.

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“… 10 It is a sleep disorder characterized by dream enactment behavior and REM sleep without atonia. 11 The violent behavior during attacks can cause harm to patients and their bedmates. 12 As a special kind of sleep disorder in PD, RBD is a strong predictor of α-synuclein pathology.…”

Section: Introductionmentioning

confidence: 99%

“… 12 As a special kind of sleep disorder in PD, RBD is a strong predictor of α-synuclein pathology. 11 The prevalence of RBD in PD is between 30% and 50%. In early PD, patients with RBD have poorer subjective motor symptoms and life quality, as well as increased severity and frequency of nonmotor features, than those without RBD.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbances and Associated Factors in Drug-Naïve Patients with Parkinson’s Disease

Zhong

Jiang

Zhu

et al. 2021

NDT

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Purpose Sleep disturbance is one of the common symptoms in Parkinson’s disease (PD). The study of sleep disturbance used to concentrate on treated PD. This study aimed to investigate the factors that are associated with the sleep quality of drug-naïve patients with PD. Patients and Methods All participants were interviewed using a standard questionnaire to collect basic information. PD severity, depression symptoms, anxiety symptoms, sleep quality, cognitive status, life quality, and the presence of rapid eye movement (REM) sleep behavior disorder (RBD) and minor hallucination were assessed using corresponding rating scales. The patients with a Pittsburgh Sleep Quality Index score ≤6 fell into the poor sleep group, and those with REM Sleep Behavior Disorder Screening Questionnaire score ≥5 were considered to have probable RBD. Results Seventy drug-naive patients with PD and 30 healthy controls matched for age, sex, and education were recruited. Up to 41.4% of the patients suffered from sleep disturbance, and 24.3% of the patients had RBD. Poor sleepers were more likely to have left-side predominant motor symptoms. Compared with good sleepers, poor sleepers, particularly female patients, had more burden in the aspect of anxiety and depression. RBD was associated with more nonmotor symptoms, poor sleep quality, bad performance in cognition orientation domain, anxiety, depression, presence of minor hallucination, and poor life quality. Conclusion Sleep disturbances are common in drug-naïve PD and require wide attention. Motor symptom laterality and gender difference in mood are associated with sleep quality. Depression, anxiety, and RBD are highly related to sleep disturbance. RBD has many comorbidities, which can influence the cognitive function and life quality of the patients.

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REM sleep behavior disorder: Mimics and variants

Cited by 32 publications

References 106 publications

Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives

Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives

Effective Treatment of Adult Parasomnias with Keishikaryukotsuboreito in Four Cases

Sleep Disturbances and Associated Factors in Drug-Naïve Patients with Parkinson’s Disease

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