As in many cultures and religions, the stigma of mental illness and treatment in the Muslim immigrant community is deep-rooted. Compounded with the cultural mistrust of the Western mental health system, many in this community live with untreated mental health conditions that not only impact themselves, but impact their family and the larger community. This article examines the Muslim immigrant community in the U.S. by providing an overview of who Muslim immigrants are and some of major psychosocial and psychological issues they face. The article will examine the impact of cultural mistrust and the stigmatization related to mental health on help-seeking behaviors among Muslim immigrants. Two case studies are presented that portray some of the struggles a Muslim immigrant faces in the U.S. Based on these case studies, recommendations for providing culturally responsive services that may mediate barriers to mental health help-seeking behaviors are presented. Finally, the authors discuss implications for future research.