Religion and Politics in the Risorgimento

Raponi, Danilo

doi:10.1057/9781137342980

Cited by 7 publications

(6 citation statements)

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“…[33][34] Such therapies have met moderate success due to the high mutation load found in colorectal cancer, and are frequently less effective against colorectal cancers with constitutively active KRas mutations. [35][36][37] The potent inhibition of HCT116 (KRAS G13D ) xenograft mice tumor growth by AF8 suggests that targeting SIRT2 activity can be a viable therapeutic strategy in colorectal cancers containing a KRAS mutation. Given the broad toxicity of AF8 and AF10 in other cancer cell lines, it is also possible that SIRT2 inhibitors can be useful for treating other type of cancers.…”

Section: Hct116mentioning

confidence: 99%

Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model

et al. 2019

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Sirtuin 2 (SIRT2) is a protein lysine deacylase that has been indicated as a therapeutic target for cancer. To further establish the role of SIRT2 in cancers, it is necessary to develop selective and potent inhibitors. Here, we report the facile synthesis of novel lysine derived thioureas as mechanism-based SIRT2 inhibitors with anticancer activity. Compounds AF8, AF10, and AF12 selectively inhibited SIRT2 with IC 50 values of 0.06, 0.15, and 0.08 μM, respectively. Compounds AF8 and AF10 demonstrated broad cytotoxicity amongst cancer cell lines, but minimal toxicity in noncancerous cells. AF8 and AF10 inhibited the anchorage-independent growth of human colorectal cancer cell line HCT116 with GI 50 values of ~7 μM. Furthermore, AF8 potently inhibited tumor growth in a HCT116 xenograft murine model, supporting that SIRT2 is a viable therapeutic target for colorectal cancer.

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Section: Hct116mentioning

confidence: 99%

Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model

et al. 2019

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“…Thousands of petitions were signed, effigies of the pope and his new Catholic bishops were burnt, demonstrations took place in Scotland, Wales and Ulster (even though the hierarchy had only been re-established in England), and it led societies like the Evangelical Alliance to take a greater interest in the political and religious affairs of Italy than they might otherwise have done. 64 These events rendered the period an extremely complex one regarding relations between the British government and the Holy See. 65 Protestant intellectuals and clergy made their disapproval clear through lectures and sermons, and the proliferation of publications criticizing Catholicism and the papacy.…”

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confidence: 99%

The Religious ‘Persecutions’ in the Grand Duchy of Tuscany and British Sympathy for Italian Nationalism, 1851–1853

Wright

2017

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The history of British relations with the states of pre-unification Italy is a neglected field of enquiry. The research that has been undertaken has tended to focus on the generally good relationship Britain shared with the Kingdom of Sardinia, the state which presided over Italy's national unification between 1859 and 1861. By contrast, the extent to which Britain's poor relations with the Papal States, the Kingdom of the Two Sicilies and the Grand Duchy of Tuscany, and the impact that negative perceptions of those countries had upon the development of British sympathy for Italian nationalism, are little understood. This article on British reactions to what the Victorians perceived as religious 'persecutions' in the Grand Duchy of Tuscany begins to redress this imbalance. Tuscany was in many respects one of the more progressive states in the Italian peninsula. Its government was moderate compared with those at Naples and Rome, it was affluent and it invested in a modern communications infrastructure. However, during the years following the revolutionary upheaval of 1848-9, the Tuscan state's policy of religious retrenchment led to a sequence of events -some of which involved British subjects -which were perceived as examples of religious 'persecution' in Victorian Britain. British reactions to these events illustrate the extent to which religion could affect British foreign policy during the midnineteenth century, and they help to explain the emergence of British sympathy for the Italian nationalist cause during the 1850s.

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“…"Roman Question" could only be solved through a revolutionary upheaval, a revolution that should not only be political but also religious. 44 This was also the position of Giuseppe Mazzini (1805-1872) who through his political movement and newspaper: "Young Italy", pursued a radical revolutionary approach as the solution of the unification of Italy. 45 Interestingly, through his political religion…”

Section: Republicans and The Free Churchesmentioning

confidence: 96%

“…43 A host of myths about them during the nineteenth century had reduced them to a tourist ploy or as a source of revenue for many novels. 44 Due to the contrasting types of nineteenth century literature on the subject: ranging from idealistic and at times fictional representations of the matter 45 to on the other side of the spectrum, condemning and denigrating depictions, 46 in between these extremes, it is not always easy to distinguish the historical accuracy in the intent of the writer. This is also aggravated by the fact that talking about clandestine groups during the Middle Ages or Protestant churches after the Reformation implies that very little of direct documentary evidence was either written by the group in question or survived the censorship of the Catholic inquisitors.…”

Section: Apostolic Waldensians and The Temporal Power Of The Popementioning

confidence: 99%

“…The chapel had in some sense become the center of public relations with the progressist environments of Turin. 44 Almost daily Bert was also in contact with the Prussian ambassador Friedrich Ludwig III, Truchsess zu Waldburg, acting together as intermediaries between the European Protestant courts and the Waldensians. The notes from the correspondence of the Waldensian "Tavola" with the Prussian supporters acknowledge the positive result upon the government of Piedmont-Sardinia of the: "attention and intervention" from their: "brothers from Germany".…”

Section: The Waldensians and The Royal Familymentioning

confidence: 99%

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Resurrecting Freedom of Religion

Palombaro¹

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Contrary to current historical reconstructions, far from being just a secular project, the Italian Risorgimento had deep spiritual foundations. Though collapsing with the unwillingness of the pope to give up his temporal power, the project of “resurrection” of freedom of religion in modern Italy became an anti-clerical project though not necessarily anti-Christian. On the one side, radical free church Protestants generally supported the Republican ideals of Giuseppe Mazzini and Giuseppe Garibaldi, while on the other side many Waldensians sided with the liberal Cavour and his formula – derived from the Swiss theologian Alexandre Vinet and his idea of: “a free Church in a free State.” A spiritual réveil or awakening preceded the political awakening that led to the emancipation of the Waldensians, an event embodying the ideals of the Risorgimento. Indeed, Waldensians played a considerable role in the Risorgimento, contributing soldiers, parliamentary representatives, educators, writers, entrepreneurs, missionaries, and most of all, individuals who fought for religious freedom.

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Religion and Politics in the Risorgimento

Cited by 7 publications

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Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model

Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model

The Religious ‘Persecutions’ in the Grand Duchy of Tuscany and British Sympathy for Italian Nationalism, 1851–1853

Resurrecting Freedom of Religion

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