Relief of Periorbital Pain After Acute Angle Closure Glaucoma Attack by Botulinum Toxin Type A

Abstract

BoNT-A is effective and well tolerated for the treatment of periorbital pain after an AACG attack. Its effects may be maintained for 3 months.

Botox A Injection for Pain after Laparoscopic Ventral Hernia: A Case Report

“…More recently, active research has been focused on Botox for use in pain syndromes such as stump pain, migraines, MPS, chronic low back pain, arthritis, and periorbital pain [9][10][11][12][13][14][15]. The exact mechanism of action is not understood, but several mechanisms independent of its paralytic properties have been proposed.…”

“…BTX, available in the United States as Botox (Allergan Inc.), has been used for many years for spasticity-related disorders and cosmetic procedures, with both its safety and efficacy proven [2,[4][5][6][7][8]. More recently, active research has been focused on Botox for use in pain syndromes such as stump pain, migraines, MPS, chronic low back pain, arthritis, and periorbital pain [9][10][11][12][13][14][15]. The exact mechanism of action is not understood, but several mechanisms independent of its paralytic properties have been proposed.…”

“…Acute and chronic pain symptoms are also an active area of clinical utilization with a yet unknown mechanism of action [9][10][11]. Injections for Temporomandibular joint spasticity pain, migraines, arthritis, stump pain after amputation, myofascial pain syndrome (MPS), and acute periorbital pain following glaucoma attacks are well described with promising results [12][13][14][15]. Current literature documents expanding use in the perioperative setting as well as recent publications in head and neck, orthopedics and oncoplastic surgery [16][17][18].…”

Uses of Botulinum Toxin a in Ophthalmology

“…A novel application of Btx-A is its use to relieve periorbital pain after an acute angle closure glaucoma attack 110 . However, this application has to be viewed and applied with caution as botulinum toxin inhibits acetylcholine release which can result in pupil mydriasis.…”

“…However, this application has to be viewed and applied with caution as botulinum toxin inhibits acetylcholine release which can result in pupil mydriasis. In 1990, a case report was published of a patient who developed an acute angle closure attack after botulinum toxin injection was administered to treat blepharospasm 110 .…”