Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective

Singh, Nitesh; Varma, Anand; Verma, Ashish; Maurya, Babu Nandan; Dash, Debabrata

doi:10.1007/s12274-016-1119-5

Cited by 44 publications

(58 citation statements)

References 27 publications

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“…Near‐infrared (NIR)‐light‐mediated nano‐medicines provide a new therapeutic strategy for thrombus therapy via rapidly converting optical energy into hyperthermia by Landau damping effect . In 2016, Dash and co‐workers first demonstrated that NIR‐irradiated gold nanorods possessed antithrombotic properties for dissolving fibrin clots . After that, van Hest et al reported a photothermal thrombolytic system based on Janus‐type erythrocyte membrane‐coated micromotors .…”

Section: Methodsmentioning

confidence: 99%

Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy

Zhang

Liu²,

Lei

et al. 2019

Advanced Science

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Although near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary embolism of post‐phototherapy fragments (>10 µm) for small vessels should not be ignored in this process. In this study, dual‐modality photothermal/photodynamic thrombolysis is explored using targeting nanoagents with an emphasis on improving biosafety as well as ameliorating the thrombolytic effect. The nanoagents can actively target glycoprotein IIb/IIIa receptors on thrombus to initiate site‐specific thrombolysis by hyperthermia and reactive oxygen species under NIR laser irradiation. In comparison to single photothermal thrombolysis, an 87.9% higher re‐establishment rate of dual‐modality photothermal/photodynamic thrombolysis by one‐time treatment is achieved in a lower limb thrombosis model. The dual‐modality thrombolysis can also avoid re‐embolization after breaking fibrin into tiny fragments. All the results show that this strategy is a safe and validated protocol for thrombolysis, which fits the clinical translational trend of nanomedicine.

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Section: Methodsmentioning

confidence: 99%

Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy

Zhang

Liu²,

Lei

et al. 2019

Advanced Science

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“…Heat generated during PTT has potential applications in the treatment of thrombi [ 79 ], port wine stains (PWSs) [ 63 ], and cancers [ 80 ]. For example, Li et al developed gold nanorods coated with RBC membranes for PTT of human lung carcinoma cells in vitro after 808 nm laser irradiation [ 81 ].…”

Section: Potential Clinical Applicationsmentioning

confidence: 99%

Phototheranostics Using Erythrocyte-Based Particles

et al. 2021

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There has been a recent increase in the development of delivery systems based on red blood cells (RBCs) for light-mediated imaging and therapeutic applications. These constructs are able to take advantage of the immune evasion properties of the RBC, while the addition of an optical cargo allows the particles to be activated by light for a number of promising applications. Here, we review some of the common fabrication methods to engineer these constructs. We also present some of the current light-based applications with potential for clinical translation, and offer some insight into future directions in this exciting field.

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“…Thrombus models were established by following the published protocols. 63 Fibrinogen from human plasma (1 mg/mL) as the physiological source of thrombus was dissolved in a solution of 50 mM Tris-HCl (pH 7.4) and 140 mM NaCl. Thrombus formation was induced by adding 1 U/mL thrombin and 2.5 mM CaCl 2 to the fibrinogen solution, which was then cultured at 37 °C for 1 h. A turbidity assay was used to monitor the process of thrombus formation by measuring the absorbance (340 nm) at 10 min intervals.…”

Section: Methodsmentioning

confidence: 99%

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

et al. 2018

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We report the construction of erythrocyte membrane-cloaked Janus polymeric motors (EM-JPMs) which are propelled by near-infrared (NIR) laser irradiation and are successfully applied in thrombus ablation. Chitosan (a natural polysaccharide with positive charge, CHI) and heparin (glycosaminoglycan with negative charge, Hep) were selected as wall materials to construct biodegradable and biocompatible capsules through the layer-by-layer self-assembly technique. By partially coating the capsule with a gold (Au) layer through sputter coating, a NIR-responsive Janus structure was obtained. Due to the asymmetric distribution of Au, a local thermal gradient was generated upon NIR irradiation, resulting in the movement of the JPMs through the self-thermophoresis effect. The reversible “on/off” motion of the JPMs and their motile behavior were easily tuned by the incident NIR laser intensity. After biointerfacing the Janus capsules with an erythrocyte membrane, the EM-JPMs displayed red blood cell related properties, which enabled them to move efficiently in relevant biological environments (cell culture, serum, and blood). Furthermore, this therapeutic platform exhibited excellent performance in ablation of thrombus through photothermal therapy. As man-made micromotors, these biohybrid EM-JPMs hold great promise of navigating in vivo for active delivery while overcoming the drawbacks of existing synthetic therapeutic platforms. We expect that this biohybrid motor has considerable potential to be widely used in the biomedical field.

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Relief from vascular occlusion using photothermal ablation of thrombus with a multimodal perspective

Cited by 44 publications

References 27 publications

Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy

Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy

Phototheranostics Using Erythrocyte-Based Particles

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

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