Relief by botulinum toxin of voiding dysfunction due to prostatitis

Botulinum toxin for the lower urinary tract

“…In patients with dysfunctional voiding due to urethral sphincter overactivity, nonbacterial prostatitis and detrusor underactivity, BoNT has been shown to have a therapeutic effect in improving voiding efficiency and recovering detrusor contractility in several patients, with few reported adverse effects [64,65]. Phelan et al [65] found that after BoNT injection, 67% of patients were able to void smoothly, with the PVR decreased by 71% and voiding pressure decreased by 38%.…”

“…The injection needle should not be inserted too deeply ( < 1 cm) to avoid injecting BoNT outside the sphincter muscle or into the bladder lumen. The dose of onBoNT-A can be 50-100 U for patients with detrusor underactivity who wish to void by abdominal pressure after treatment, or 100 U for patients with DSD, dysfunctional voiding or poor relaxation of the urethral sphincter [63][64][65][66]. Medications for reducing urethral resistance can be discontinued after the BoNT injections [67,69].…”

195 Intraprostatic Injection of Botulinum Toxin-A in Patients with Refractory Chronic Pelvic Pain Syndrome: The Transurethral vs. Transrectal Approach

“…These studies used different routes of injections (transurethral, transrectal and transperineal), different doses of BTX-A (30-200 U) and different outcome variables (uroflowmetry, visual pain analogue score, pelvic floor tenderness, Global Response Assessment and total CPSI) [24][25][26][27][28][29].…”

“…Hence, in the studies by Maria et al [24] and Zermann et al [25], the BTX-A injection was directed to the region of the external urethral sphincter. However, other studies showed that BTX-A has a direct effect on pain through the modulation of pain neurotransmitters [32,33].…”

Botulinum in Modern Urology

“…Большой экспериментальный и клинический опыт при-менения БТ для лечения гиперрефлексии детрузора, детрузорно-сфинктерной диссинергии (ДСД), дисфункци-онального мочеиспускания, симптомов нарушенного мочеиспускания на фоне доброкачественной гиперпла-зии предстательной железы (ДГПЖ), простатита был нако-плен в мире уже к началу этого столетия [15][16][17][18][19].…”