Reliable surveillance of tick-borne encephalitis in European countries is necessary to improve the quality of vaccine recommendations

Stefanoff, Paweł; Polkowska, Aleksandra; Giambi, Cristina; Lévy-Brühl, Daniel; O’Flanagan, D; Dematte, L; Lopalco, Pietro Luigi; Mereckiene, Jolita; Johansen, Kari; D’Ancona, Fortunato

doi:10.1016/j.vaccine.2010.11.077

Cited by 31 publications

(20 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An analysis of notified TBE cases in the 5-year period from 2009 to 2013 confirms Slovenia as one of the countries, together with the Baltic states and the Russian Federation, where reported incidence per 100,000 is the highest in Europe [11,28]. With an estimate of 10.95 DALYs per 100,000 per year (95% UI: 10.25-11.65), TBE has an important impact on the health of the Slovenian population.…”

Section: Discussionmentioning

confidence: 99%

Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013

et al. 2017

View full text Add to dashboard Cite

With an annual incidence between 8 and 15 per 100,000 population in the period from 2009 to 2013, Slovenia has one of the highest notified incidences of tick-borne encephalitis (TBE) in Europe. TBE vaccination coverage remains at about 7.3%. To inform vaccination policy, we used surveillance data from 2009 to 2013 to calculate the overall and age- and sex-specific mean annual TBE incidence. We estimated disability-adjusted life years (DALYs) with 95% uncertainty intervals (UI), using the Burden of Communicable Diseases in Europe approach from the European Centre for Disease Prevention and Control. The mean annual incidence was 11.6 per 100,000 population, peaking in older age groups (50–74 years: 18.5/100,000) while relatively lower among children (5–14 years: 10.2/100,000). We estimated an overall 10.95 DALYs per 100,000 population per year (95% UI: 10.25-11.65). In contrast to the TBE incidence, the disease burden in children aged 5–14 years was higher than in adults aged 50–74 years: 17.31 (95% UI: 14.58–20.08) and 11.58 (95% UI: 10.25–12.91) DALYs per 100,000 stratum-specific population, respectively. In a limited resource setting where prioritisation of TBE vaccination strategies is required, vaccination programmes targeting children may have a higher impact on disease burden.

show abstract

Section: Discussionmentioning

confidence: 99%

Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The system has fair sensitivity overall (48%), but diagnosis of TBE may be different in known endemic regions and the remaining parts of the country [33]. A standardized case definition is used to classify each reported case [34], as follows: a possible case is one that presents with symptoms of meningo-encephalitis, and had visited an endemic area during April-November; a probable case is one that presents with symptoms of meningo-encephalitis and either the presence of an epidemiological link (consumption of raw dairy products) or detection of IgM in serum by enzyme-linked immunosorbent assay (ELISA); a confirmed case is one that presents with symptoms of meningo-encephalitis and laboratory confirmation (IgM and IgG detection in serum, or detection of antibodies in CSF, or confirmation by neutralization test independently from other test results). All eligible cases in this study met the surveillance definition of a probable or confirmed TBE case, were not vaccinated against TBE according to the recommended schedule in the previous 5 years, had disease onset between January 1, 2009 and December 31, 2009, and gave informed consent to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

A National Case-Control Study Identifies Human Socio-Economic Status and Activities as Risk Factors for Tick-Borne Encephalitis in Poland

et al. 2012

Self Cite

View full text Add to dashboard Cite

BackgroundTick-borne encephalitis (TBE) is endemic to Europe and medically highly significant. This study, focused on Poland, investigated individual risk factors for TBE symptomatic infection.Methods and FindingsIn a nation-wide population-based case-control study, of the 351 TBE cases reported to local health departments in Poland in 2009, 178 were included in the analysis. For controls, of 2704 subjects (matched to cases by age, sex, district of residence) selected at random from the national population register, two were interviewed for each case and a total of 327 were suitable for the analysis. Questionnaires yielded information on potential exposure to ticks during the six weeks (maximum incubation period) preceding disease onset in each case. Independent associations between disease and socio-economic factors and occupational or recreational exposure were assessed by conditional logistic regression, stratified according to residence in known endemic and non-endemic areas. Adjusted population attributable fractions (PAF) were computed for significant variables. In endemic areas, highest TBE risk was associated with spending ≥10 hours/week in mixed forests and harvesting forest foods (adjusted odds ratio 19.19 [95% CI: 1.72–214.32]; PAF 0.127 [0.064–0.193]), being unemployed (11.51 [2.84–46.59]; 0.109 [0.046–0.174]), or employed as a forester (8.96 [1.58–50.77]; 0.053 [0.011–0.100]) or non-specialized worker (5.39 [2.21–13.16]; 0.202 [0.090–0.282]). Other activities (swimming, camping and travel to non-endemic regions) reduced risk. Outside TBE endemic areas, risk was greater for those who spent ≥10 hours/week on recreation in mixed forests (7.18 [1.90–27.08]; 0.191 [0.065–0.304]) and visited known TBE endemic areas (4.65 [0.59–36.50]; 0.058 [−0.007–0.144]), while travel to other non-endemic areas reduced risk.ConclusionsThese socio-economic factors and associated human activities identified as risk factors for symptomatic TBE in Poland are consistent with results from previous correlational studies across eastern Europe, and allow public health interventions to be targeted at particularly vulnerable sections of the population.

show abstract

“…Although TBE has a lower public health impact in Denmark, France, Greece, Italy, Norway and Turkey, new TBE foci or possible occurrence of TBE virus are reported in these countries [25][26][27]. Austria is the only country with progressively decreasing incidence rates since 1981 due to its vaccination campaign, but the occurrence of TBE may be relevant to unvaccinated tour-ists [24,25,28].…”

Section: Introductionmentioning

confidence: 99%

“…But the surveillance and notification schemes are not uniform, not always mandatory, and may affect the prevalence estimates for the disease in certain regions. Main problems are the lack of a Europe-wide standard case definition, varying diagnostic procedures and wide differences in the intensity and quality of national surveillance of TBE cases [25,28]. Thus, surveillance data from different countries are difficult to compare.…”

Section: Introductionmentioning

confidence: 99%

Tick-borne encephalitis in Europe, 2007 to 2009

et al. 2011

View full text Add to dashboard Cite

Reliable surveillance of tick-borne encephalitis in European countries is necessary to improve the quality of vaccine recommendations

Cited by 31 publications

References 17 publications

Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013

Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013

A National Case-Control Study Identifies Human Socio-Economic Status and Activities as Risk Factors for Tick-Borne Encephalitis in Poland

Tick-borne encephalitis in Europe, 2007 to 2009

Contact Info

Product

Resources

About