Reliable Quantitative SERS Analysis Facilitated by Core–Shell Nanoparticles with Embedded Internal Standards

Shen, Wei; Lin, Xuan Yu; Jiang, Chaoyang; Li, Chaoyu; Lin, Haixin; Huang, Jingtao; Wang, Shuo; Liu, Guokun; Yan, Xiaomei; Qi-ling, Zhong; Ren, Bin

doi:10.1002/ange.201502171

Cited by 86 publications

(83 citation statements)

References 26 publications

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“…For example, the EF of Au@ATP@Ag5 was thirty two times higher than that of Au@Ag@ATP5. This result is in line with previous observations for nanoparticles with spherical [24] and star-like morphologies [25]. Fine control over the plasmonic properties of the anisotropic NMs led us to the important finding that the EF depends on the plasmon resonance.…”

Section: Sers Studysupporting

confidence: 87%

Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods

2016

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The design and synthesis of plasmonic nanoparticles with Raman-active molecules embedded inside them are of significant interest for sensing and imaging applications. However, direct synthesis of such nanostructures with controllable shape, size, and plasmonic properties remains extremely challenging. Here we report on the preparation of uniform Au@Ag core/shell nanorods with controllable Ag shells of 1 to 25 nm in thickness. 1,4-Aminothiophenol (4-ATP) molecules, used as the Raman reporters, were located between the Au core and the Ag shell. Successful embedding of reporter molecules inside the core/shell nanoparticles was confirmed by the absence of selective oxidation of the amino groups, as measured by Raman spectroscopy. The dependence of Raman intensity on the location of the reporter molecules in the inside and outside of the nanorods was studied. The molecules in the interior showed strong and uniform Raman intensity, at least an order of magnitude higher than that of the molecules on the nanoparticle surface. In contrast to the usual surface-functionalized Raman tags, aggregation and clustering of nanoparticles with embedded molecules decreased the surface-enhanced Raman scattering (SERS) signal. The findings from this study provide the basis for a novel detection technique of low analyte concentration utilizing the high SERS response of molecules inside the core/shell metal nanostructures. As an example, we show robust SERS detection of thiram fungicide as low as 10 −9 M in solutions.

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Section: Sers Studysupporting

confidence: 87%

Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods

2016

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“…Insufficient chloride ions would not overcome electrostatic repulsion between AgNPs effectively to achieve more hotspots; while excessive chloride ions could induce excessive aggregation and precipitation of AgNPs, both are not preferred for SERS measurement. Moreover, the SERS spectra of analytes are time dependent between the induction of the aggregation and the measurement [19,20]. However, to our knowledge, there are no systematic or comprehensive studies that aim at evaluating the effect of NaCl concentrations and the time of incubating paper substrate in colloidal AgNPs to paper SERS performance.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma

Huang

Cao

Sun

et al. 2017

Journal of Nanomaterials

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Characterization and optimization of paper SERS substrate were performed in detail, in which morphologies and distribution of silver nanoparticles (AgNPs) on the paper substrate pretreated with different concentrations of NaCl and the subsequent soaking with colloidal AgNPs for different period of time were evaluated. Our results show that both NaCl concentration and soaking time with AgNPs have a significant influence on SERS enhancement, showing that an optimal EF of 2.27 × 10 7 was achieved when the paper substrate was treated with 20 mM NaCl and one-hour soak with AgNPs. Moreover, seminal plasma (SP) was specifically selected to evaluate the performance of paper-based SERS substrate for potential clinical detection and diagnosis. The optimization of the paper SERS substrate demonstrates potential applications in reliable on-site detection of SP and clinical diagnosis of fertilityrelated diseases as well.

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“…Shaking can be adopted to accelerate the migration with emulsion resulted [16]. Metallic luster can be observed at the DCE/water interface, suggesting MGN unit localization, which allows the formation of efficient substrates for immediate SERS detection considering the CMS NPs with stable and strong SERS signals [30]. What's more, precipitation (without DCE) or assembly (with DCE) led by aggregation of the CMS NPs was found at the high concentration of free GSH in the solution.…”

Section: Principle Of Cu 2+ Detection By Target Induced Nanoparticlesmentioning

confidence: 98%

“…al. [30] Here, silver shell was selected to achieve the highest possible enhancement as the SERS substrate, while the report molecules (Mpy) in the CMS NPs could directly give SERS signals. The factors influencing the stability of NPs on the interface include electrostatic repulsion between the NPs, as well as the attraction force and thermal disturbance force existing on the interface [34].…”

Section: Principle Of Cu 2+ Detection By Target Induced Nanoparticlesmentioning

confidence: 99%

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Target induced interfacial self-assembly of nanoparticles: A new platform for reproducible quantification of copper ions

Liang

Zhang

et al. 2016

Talanta

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Reliable Quantitative SERS Analysis Facilitated by Core–Shell Nanoparticles with Embedded Internal Standards

Cited by 86 publications

References 26 publications

Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods

Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods

Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma

Target induced interfacial self-assembly of nanoparticles: A new platform for reproducible quantification of copper ions

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