Reliability of single and paired pulse transcranial magnetic stimulation parameters across eight testing sessions

Dyke, Katherine; Kim, Soyoung; Jackson, Georgina M.; Jackson, Stephen R.

doi:10.1016/j.brs.2018.08.008

Cited by 13 publications

(5 citation statements)

References 8 publications

(16 reference statements)

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“…We attribute this incongruity to the expression of ICF. The majority of paired-pulse TMS studies have normalised the paired-pulse ICF and ICI amplitude into a percentage of the corresponding single-pulse MEP amplitude [ 58 ], which bears the risk of a ceiling effect when rTMS raises the amplitude of single-pulse MEP through long-term potentiation (LTP) [ 59 , 60 ]. The mechanisms of ICF also remain elusive at present, we therefore adopted the normalisation of baseline MEP sp amplitude to exclude the individual variability while preserving possible rTMS-induced variation of the parameters.…”

Section: Discussionmentioning

confidence: 99%

Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition

Tian

Izumi

2022

Brain Sciences

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The activity of excitatory and inhibitory neural circuits in the motor cortex can be probed and modified by transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS), noninvasively. At present, not only has a consensus regarding the interhemispheric effect of high frequency rTMS not been reached, but the attributes of these TMS-related circuits are also poorly understood. To address this question comprehensively, we integrated a single- and paired-pulse TMS evaluation with excitatory 20-Hz rTMS intervention in order to probe the interhemispheric effect on the intracortical circuits by high-frequency rTMS. In the rest state, after 20-Hz rTMS, a significant increase of single-pulse MEP and paired-pulse intracortical facilitation (ICF) in the non-stimulated hemisphere was observed with good test–retest reliability. Intracortical inhibition (measured by the cortical silent period) in the unstimulated hemisphere also increased after rTMS. No significant time–course change was observed in the sham-rTMS group. The results provide the evidence that 20-Hz rTMS induced a reliable interhemispheric facilitatory effect. Findings from the present study suggest that the glutamatergic facilitatory system and the GABAergic inhibitory system may vary synchronously.

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Section: Discussionmentioning

confidence: 99%

Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition

Tian

Izumi

2022

Brain Sciences

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“…This is in accordance with previously reported low intersession variability and high test-retest reliability for LICI (Farzan et al, 2010). We selected LICI as paired pulse TMS-EMG measure, since repeatability appears to be poorer and more variable for SICI and ICF Boroojerdi et al, 2000;Du et al, 2014;Dyke et al, 2018;Fleming et al, 2012;Hermsen et al, 2016;Maeda et al, 2002;Orth et al, 2003). In Chapter 4, we confirmed the high repeatability of the single (Casarotto et al, 2010;Kerwin et al, 2018;Lioumis et al, 2009) and paired pulse TEP over one week (Farzan et al, 2010;Premoli et al, 2014b).…”

Section: Repeatabilitysupporting

confidence: 88%

“…Only two studies evaluated long-term repeatability. They showed the stability of rMT across multiple TMS sessions over a period of six months (Dyke et al, 2018) or five years (Kimiskidis et al, 2004). Such longterm studies are also required for the other excitability measures to determine the true potential of TMS in longitudinal studies (e.g.…”

Section: Repeatabilitymentioning

confidence: 99%

Multimodal TMS

Goede¹,

Annika²

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Contents 1 General introduction 2 Repeatability of long intracortical inhibition in healthy subjects 3 Accurate coil positioning is important for single and paired pulse TMS on the subject level 4 Spatiotemporal dynamics of single and paired pulse TMS-EEG responses 5 Infraslow activity as a potential modulator of cortical excitability 6 Single and paired pulse transcranial magnetic stimulation in drug naïve epilepsy 7 Long-interval intracortical inhibition as biomarker for epilepsy: a transcranial magnetic stimulation study 8 Multimodal TMS has the potential to improve the diagnostic process in epilepsy

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“…Reliability of the different IO-curve parameters (slope, peak-slope and maximum/plateau) were also investigated by five studies ( Carroll et al, 2001 ; Kukke et al, 2014 ; Liu and Au-Yeung, 2014 ; Dyke et al, 2018 ; Therrien-Blanchet et al, 2022 ) and compared between the contra- and ipsilateral sides within one study ( Schambra et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

“…Reliability of the parameters of the IO-curve (MEP max , slope and s 50 - the amplitude that evokes a MEP halfway between baseline and MEP max) were estimated within seven studies ( Carroll et al, 2001 ; Malcolm et al, 2006 ; Kukke et al, 2014 ; Liu and Au-Yeung, 2014 ; Schambra et al, 2015 ; Dyke et al, 2018 ; Therrien-Blanchet et al, 2022 ). ICC values for the slope were classified as good in five studies ( Carroll et al, 2001 ; McDonnell et al, 2004 ; Malcolm et al, 2006 ; Liu and Au-Yeung, 2014 ; Therrien-Blanchet et al, 2022 ) and moderate in one ( Kukke et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

On the reliability of motor evoked potentials in hand muscles of healthy adults: a systematic review

Osnabruegge,

Kanig,

Schwitzgebel

et al. 2023

Front. Hum. Neurosci.

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AimsMotor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) over the primary motor cortex are used as a neurophysiological marker of cortical excitability in clinical and scientific practice. Though, the reliability of this outcome parameter has not been clarified. Using a systematic approach, this work reviews and critically appraises studies on the reliability of MEP outcome parameters derived from hand muscles of healthy subjects and gives a proposal for most reliable TMS practice.MethodsA systematic literature research was performed in PubMed, according to the PRISMA guidelines. Articles published up to March 2023 that were written in English, conducted repeated measurements from hand muscles of healthy subjects and reliability analysis were included. The risk of publication bias was determined. Two authors conducted the literature search and rated the articles in terms of eligibility and methodological criteria with standardized instruments. Frequencies of the checklist criteria were calculated and inter-rater reliability of the rating procedure was determined. Reliability and stimulation parameters were extracted and summarized in a structured way to conclude best-practice recommendation for reliable measurements.ResultsA total of 28 articles were included in the systematic review. Critical appraisal of the studies revealed methodological heterogeneity and partly contradictory results regarding the reliability of outcome parameters. Inter-rater reliability of the rating procedure was almost perfect nor was there indication of publication bias. Identified studies were grouped based on the parameter investigated: number of applied stimuli, stimulation intensity, reliability of input-output curve parameters, target muscle or hemisphere, inter-trial interval, coil type or navigation and waveform.ConclusionThe methodology of studies on TMS is still subject to heterogeneity, which could contribute to the partly contradictory results. According to the current knowledge, reliability of the outcome parameters can be increased by adjusting the experimental setup. Reliability of single pulse MEP measurement could be optimized by using (1) at least five stimuli per session, (2) a minimum of 110% resting motor threshold as stimulation intensity, (3) a minimum of 4 s inter-trial interval and increasing the interval up to 20 s, (4) a figure-of-eight coil and (5) a monophasic waveform. MEPs can be reliably operationalized.

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Reliability of single and paired pulse transcranial magnetic stimulation parameters across eight testing sessions

Cited by 13 publications

References 8 publications

Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition

Interhemispheric Facilitatory Effect of High-Frequency rTMS: Perspective from Intracortical Facilitation and Inhibition

Multimodal TMS

On the reliability of motor evoked potentials in hand muscles of healthy adults: a systematic review

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