Surface deformation of alpine peatland in China has an important effect on runoff and is of great significance for wetland ecosystem protection. However, spatio-temporal characteristics of alpine peatland surface deformation in China lack systematic studies, and the driving mechanism is not yet clear. In this study, we selected the alpine peatland of Maduo County in China as the research object, surface deformation of peatland based on the small baseline subset radar interferometry (SBAS-InSAR) technique was obtained, we analyzed spatiotemporal deformation characteristics and patterns of peatland, explored the driving mechanism of the peatland surface deformation with single-factor and multi-factor combinations of Geo-detector, respectively. The results showed that the overall subsidence rates of peatlands in Maduo County, China slowed down year by year from 2018 to 2020, but there was seasonal freezing and thawing, subsidence rates of peatlands at high elevation and high slopes were stable, peatlands at low elevation and low slope were vulnerable to disturbance, subsidence rates are largest. Maliecuo, Bailongqu, and Gaerlawangzang regions were serious subsidence, the maximum subsidence rate was 159 mm/year. Meteorological factors and geological conditions were the main reasons for the surface deformation of alpine peatland in Maduo County, China. This study provides a theoretical basis for the conservation and restoration of peatland ecosystems in the alpine regions of China.