Reliability of quantitative motor unit action potential parameters

Takehara, Itaru; Chu, Jennifer; Li, Tung-Chou; Schwartz, Ira

doi:10.1002/mus.20046

Cited by 17 publications

(11 citation statements)

References 7 publications

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“…In the three repeated manual measurements, the mean durations ranged from 14.9 to 15.7 ms, and the largest difference between durations of MUAPs from the same MU was 8 ms [16]. Similar observations of such low degrees of reliability of manual duration readings have been reported by other authors [37][38][39].…”

Section: Variability Of Manual Measurementssupporting

confidence: 85%

Motor Unit Action Potential Duration: Measurement and Significance

Carreño¹,

Gila-Useros²,

Malanda³

2012

Advances in Clinical Neurophysiology

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Section: Variability Of Manual Measurementssupporting

confidence: 85%

Motor Unit Action Potential Duration: Measurement and Significance

Carreño¹,

Gila-Useros²,

Malanda³

2012

Advances in Clinical Neurophysiology

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“…This might have been related to the high variability inherent in the MUP phase measures [21-23] or again due to a lack of statistical power resulting from the small sample size recruited, since there was a tendency for the severe CTS group to have more phases and turns in their MUP waveforms (Table 3). Other researchers have found low reliably in determining MUP onset and end markers as compared to the high reliability found in determining the peaks [19,21,24]. Calder et al [19] recently concluded that MUP duration (ICC: -0.29) and the number of phases in the MUP (ICC: -0.69) had poor within-subject reliability.…”

Section: Discussionmentioning

confidence: 99%

Assessing motor deficits in compressive neuropathy using quantitative electromyography

Nashed

Hamilton-Wright

Stashuk

et al. 2010

J NeuroEngineering Rehabil

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BackgroundStudying the changes that occur in motor unit potential trains (MUPTs) may provide insight into the extent of motor unit loss and neural re-organization resulting from nerve compression injury. The purpose of this study was to determine the feasibility of using decomposition-based quantitative electromyography (DQEMG) to study the pathophysiological changes associated with compression neuropathy.MethodsThe model used to examine compression neuropathy was carpal tunnel syndrome (CTS) due to its high prevalence and ease of diagnosis. Surface and concentric needle electromyography data were acquired simultaneously from the abductor pollicis brevis muscle in six individuals with severe CTS, eight individuals with mild CTS and nine healthy control subjects. DQEMG was used to detect intramuscular MUPTs during constant-intensity contractions and to estimate parameters associated with the surface- and needle-detected motor unit potentials (SMUPs and MUPs, respectively). MUP morphology and stability, SMUP morphology and motor unit number estimates (MUNEs) were compared among the groups using Kruskal-Wallis tests.ResultsThe severe CTS group had larger amplitude and longer duration MUPs and smaller MUNEs than the mild CTS and control groups, suggesting that the individuals with severe CTS had motor unit loss with subsequent collateral reinnervation, and that DQEMG using a constant-intensity protocol was sensitive to these changes. SMUP morphology and MUP complexity and stability did not significantly differ among the groups.ConclusionsThese results provide evidence that MUP amplitude parameters and MUNEs obtained using DQEMG, may be a valuable tool to investigate pathophysiological changes in muscles affected by compressive motor neuropathy to augment information obtained from nerve conduction studies. Although there were trends in many of these measures, in this study, MUP complexity and stability and SMUP parameters were, of limited value.

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“…Algorithms used to automatically measure MUP duration are based on amplitude and slope criteria, but because of variable amounts of background noise, the algorithms have low stability and visual inspection and manual marker adjustments are often required (Bischoff et al, 1994;Stalberg et al, 1995;Takehara et al, 2004b). Previous studies have shown low reliability in manual placement of duration markers and therefore manual corrections do not guarantee reliable estimates of MUP duration (Chu et al, 2003;Nandedkar et al, 1988;Rodriguez et al, 2007;Stalberg et al, 1986;Takehara et al, 2004a). In a study conducted by Rodriquez et al (Rodriguez et al, 2007) where the variability between two experienced electromyographers in manual measurements of MUP duration using four automated methods was examined, significant differences within electromyographers and between electromyographers were found in the tibialis anterior (TA) muscle but not in the FDI.…”

Section: Mup Durationmentioning

confidence: 94%