Reliability of Platelet-Derived Endothelial Cell Growth Factor as a Prognostic Factor for Oral and Oropharyngeal Carcinomas

Tsuzuki, Hideaki; Sunaga, Hiroshi; Ito, Toshihisa; Narita, Norihiko; Sugimoto, Chizuru; Fujieda, Shigeharu

doi:10.1001/archotol.131.12.1071

Cited by 12 publications

(8 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In oral and oropharyngeal cancer, literature data suggested that TP is a poor prognostic indicator [22, 23], while our data do not establish a correlation between TP expression and the main clinical-pathological parameters such as sex, age, cyto-histological grade, tumour size or nodal status. However, we found that patients with OSC with the higher MVD showed a better overall survival as compared to the patients with the lower MVD, probably as a consequence of 5-FU adjuvant therapy.…”

Section: Discussioncontrasting

confidence: 99%

A possible role of thymidine phosphorylase expression and5‐fluorouracil increased sensitivity in oropharyngeal cancer patients

Ranieri

Grammatica²,

Patruno

et al. 2007

J Cellular Molecular Medi

View full text Add to dashboard Cite

Thymidine Pi deoxyribosyltransferase (TP) is an enzyme involved in DNA synthesis up-regulated in tumours and it is also a pro-angiogenic factor. TP cannot activate capecitabine, because capecitabine first needs conversion by carboxylesterase and cytidine deaminase into 5-deoxy-fluorouridine. This compound can be activated by TP to 5-fluorouracil (5-FU). Although TP is not necessary for 5-FU toxicity, experimental data suggest that high levels of TP correlate with an enhanced response to 5-FU therapy. In this study, we have analysed by immunohistochemistry CD34, CD68 and TP positive cells in bioptic samples from 53 patients with T1–3 N0–1 M0 oropharyngeal squamous cell carcinoma (OSC) and from 24 patients with non-dysplastic oropharyngeal leukoplakia (NDOLP). Results showed that the mean of TP-positive cells, CD68 positive macrophages and CD34 positive endothelial cells eval-uated as microvessel density (MVD) was significantly higher in OSC than in NDOLP. Moreover, at a median follow-up of 19 months, patients with TP expression and higher MVD showed a better survival rate as compared to those with low MVD, probably as a consequence of 5-FU-based therapy.We hypothesized a role for TP in oropharyngeal tumourigenesis and 5-FU activation in the adjuvant setting of OSC patients.

show abstract

Section: Discussioncontrasting

confidence: 99%

A possible role of thymidine phosphorylase expression and5‐fluorouracil increased sensitivity in oropharyngeal cancer patients

Ranieri

Grammatica²,

Patruno

et al. 2007

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…However, Tsuzuki et al (37), found no correlation between c-myc and 5-year survival of patients with oral and oropharangeal carcinomas. In our multivariate model, the increase in c-myc levels was positively statistically correlated with the risk of death.…”

Section: Discussionmentioning

confidence: 97%

Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

et al. 2014

View full text Add to dashboard Cite

Abstract.Myc genes are a family of proto-oncogenes whose proteins are implicated in the regulation of cell proliferation, differentiation and apoptosis, and in regulating the activity of genes involved in cell division. The aim of the present study was to establish a quantitative description of the expression of c-myc and evaluate its relationship with other clinical and prognostic factors, as well as to establish a multivariate survival prediction model. This is a retrospective study of 68 patients diagnosed with oral squamous cell carcinoma (OSCC). We constructed a tissue microarray for investigating the expression of c-myc by immunohistochemistry. Statistical analyses were carried out, and a multivariate model that predicts survival was established. The average expression of c-myc was 50.32 (SD, 26.05) with a range from 6.60 to 99.

show abstract

“…BCL2 is an antiapoptotic gene and increased expression is associated with poor responses to systemic treatment of cancer (Andersen et al, 2005;Kausch et al, 2005). Colony stimulating factor-1 receptor (CSFR1) is involved in tumour cell invasion and migration, and high level expression is associated with poor prognosis in cancer patients (Tsuzuki et al, 2005). In various cervical cancer cell lines known to exhibit different degrees of aggressivity, the highest levels of colony stimulating factor are found in the most aggressive cell lines (Bretscher et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Molecular profiling of cervical cancer progression

Hagemann

Božanović²,

Hooper

et al. 2007

Br J Cancer

View full text Add to dashboard Cite

Most cancer patients die of metastatic or recurrent disease, hence the importance to identify target genes upregulated in these lesions. Although a variety of gene signatures associated with metastasis or poor prognosis have been identified in various cancer types, it remains a critical problem to identify key genes as candidate therapeutic targets in metastatic or recurrent cancer. The aim of our study was to identify genes consistently upregulated in both lymph node micrometastases and recurrent tumours compared to matched primary tumours in human cervical cancer. Taqman Low-Density Arrays were used to analyse matched tumour samples, obtained after laser-capture microdissection of tumour cell islands for the expression of 96 genes known to be involved in tumour progression. Immunohistochemistry was performed for a panel of up-and downregulated genes. In lymph node micrometastases, most genes were downregulated or showed expressions equal to the levels found in primary tumours. In more than 50% of lymph node micrometastases studied, eight genes (AKT, BCL2, CSFR1, EGFR1, FGF1, MMP3, MMP9 and TGF-b) were upregulated at least two-fold. Some of these genes (AKT and MMP3) are key regulators of epithelial -mesenchymal transition in cancer. In recurrent tumours, almost all genes were upregulated when compared to the expression profiles of the matched primary tumours, possibly reflecting their aggressive biological behaviour. The two genes showing a consistent downregulated expression in almost all lymph node metastases and recurrent tumours were BAX and APC. As treatment strategies are very limited for metastatic and recurrent cervical cancer, the upregulated genes identified in this study are potential targets for new molecular treatment strategies in metastatic or recurrent cervical cancer.

show abstract

Reliability of Platelet-Derived Endothelial Cell Growth Factor as a Prognostic Factor for Oral and Oropharyngeal Carcinomas

Cited by 12 publications

References 57 publications

A possible role of thymidine phosphorylase expression and5‐fluorouracil increased sensitivity in oropharyngeal cancer patients

A possible role of thymidine phosphorylase expression and5‐fluorouracil increased sensitivity in oropharyngeal cancer patients

Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

Molecular profiling of cervical cancer progression

Contact Info

Product

Resources

About