Reliability of Platelet-Derived Endothelial Cell Growth Factor as a Prognostic Factor for Oral and Oropharyngeal Carcinomas

Abstract

Objective: To identify a strong prognostic biological marker for patients with oral and oropharyngeal squamous cell carcinomas. Design: We evaluated the protein expressions of 26 tumor-associated factors, including cytokines and cytokine receptors (granulocyte colony-stimulating factor [G-CSF], interleukin 10 [IL-10], G-CSF receptor [G-CSFR], and IL-12 receptor); angiogenic factors (platelet-derived endothelial cell growth factor [PD-ECGF] and vessel count); cell cycle-related proteins (p27, cyclin D1, and cyclin E); apoptosis-related factors (wild-type p53, Bax, Bcl-2, apoptotic index, Fas, and Fas ligand); oncogene proteins (c-fos and c-Myc); cell-surface proteins (P-glycoprotein, multidrug resistance-associated protein, nm23, and CD40); intracellular proteins (aryl hydrocarbon receptor nuclear translocator, aryl hydrocarbon receptor, and heat shock protein 27); and DNA mismatch-repair genes (protein encoded by human mutL homologue 1 and the human mutS homologue of the chromosome 2p gene) by means of immunohistochemical analysis.

A possible role of thymidine phosphorylase expression and5‐fluorouracil increased sensitivity in oropharyngeal cancer patients

“…In oral and oropharyngeal cancer, literature data suggested that TP is a poor prognostic indicator [22, 23], while our data do not establish a correlation between TP expression and the main clinical-pathological parameters such as sex, age, cyto-histological grade, tumour size or nodal status. However, we found that patients with OSC with the higher MVD showed a better overall survival as compared to the patients with the lower MVD, probably as a consequence of 5-FU adjuvant therapy.…”

Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

“…However, Tsuzuki et al (37), found no correlation between c-myc and 5-year survival of patients with oral and oropharangeal carcinomas. In our multivariate model, the increase in c-myc levels was positively statistically correlated with the risk of death.…”

Molecular profiling of cervical cancer progression

“…BCL2 is an antiapoptotic gene and increased expression is associated with poor responses to systemic treatment of cancer (Andersen et al, 2005;Kausch et al, 2005). Colony stimulating factor-1 receptor (CSFR1) is involved in tumour cell invasion and migration, and high level expression is associated with poor prognosis in cancer patients (Tsuzuki et al, 2005). In various cervical cancer cell lines known to exhibit different degrees of aggressivity, the highest levels of colony stimulating factor are found in the most aggressive cell lines (Bretscher et al, 2000).…”