Reliability of Island Flaps Raised After Superficial and Deep Burn Injury

Borman, Hüseyin; Maral, Tuğrul; Demirhan, Beyhan; Haberal, Mehmet

doi:10.1097/00000637-200045040-00007

Cited by 13 publications

(12 citation statements)

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“…Ten of the 55 studies had models that would be classified as chronic wound models in both Davidson 8 and the Mogford and Mustoe 2 divisions. In an effort to replicate ischemic conditions, nine of the studies report work on skin flap surgeries 5,9–16 . One study used adriamycin extravasation as a dermonecrotic model 17 .…”

Section: Type Of Modelmentioning

confidence: 99%

Rat models of skin wound healing: A review

Dorsett‐Martin

2004

Wound Repair Regeneration

279

144

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Rats have been widely used in the study of skin wound healing and the efficacy of different treatment modalities. This particular animal species is often selected for its availability, low cost, and small size. To define the current use of rat skin wound healing models, this manuscript provides a review of articles published between 2000 and 2003 that chose rats as their research animals. Of the 55 articles reviewed, it was found that 38.2% of the studies used incisional models and 38.2% used excisional models, with some studies using combinations. The majority of the studies (78.2%) used the rat's dorsum as the wound location. Male Sprague Dawley in the 250-300 gram weight range were the most preferred rats. Sodium pentobarbital/ pentobarbitone was the most commonly used anesthetic choice. Similarities and differences in the selected experimental conditions are noted and questions are raised with regard to comparability between studies and the ability to transfer the data from the animal model to the human clinical situation. Attempts to compare studies for the advancement of wound healing knowledge are being hampered by the differences found between the studies. Standardization in reporting could facilitate comparisons and may instigate additional research that favors the inevitable comparisons between the studies. Thus, universal reporting requirements need to be developed for animal wound healing studies. (WOUND REP REG 2004;12:591-599)

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Section: Type Of Modelmentioning

confidence: 99%

Rat models of skin wound healing: A review

Dorsett‐Martin

2004

Wound Repair Regeneration

279

144

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“…Another investigation demonstrated that partial superficially and deeply burned skin could also be used for island skin flaps without adversely affecting flap survival [2]. In the latter study the induced burn wounds were considerably smaller than the flap.…”

Section: Discussionmentioning

confidence: 94%

“…In a previous study we demonstrated that superficially and deeply burned wounds covering small portions of epigastric island flaps had no negative impact on flap survival [2]. The present study was designed to determine whether increasing the burned portion of the flap has any untoward effect on flap survival, and to ascertain what proportion of superficial and deep partial-thickness burn on an island flap can be used in the early postburn period.…”

Section: Introductionmentioning

confidence: 89%

“…Superficial and deep dermal burns were produced using the same model used in our previous study [2], originally described by Sawada et al [14]. In this model a 2×2 cm, 3 mm-thick piece of lint cloth is immersed in boiling water (100°C) and then placed on the right half of each animal's ventrum, within the boundaries of the rat epigastric flap.…”

Section: Burn Modelmentioning

confidence: 99%

“…It may also be desirable to avoid surgery on the remaining healthy unburned tissue if there is a good alternative. The results of experiments in which acutely burned tissue was used as flaps have been promising, and it appears that this may be a feasible form of therapy in burn wound management [1,2]. This method allows closure of a full-thickness burn with vascularized, partial-thickness, burned skin that is generally available in the burn zone.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The use of superficial and deep partial-thickness burned tissue for flap fabrication

Borman¹,

Maral

Bilezikçi

et al. 2002

European Journal of Plastic Surgery

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When flaps are indicated for early wound closure in extensive burns, and there is limited unburned local tissue to design these, one option may be to use a partial-thickness burned area as a flap for construction in the acute phase. This study examined the proportions of superficial and deep partial-thickness burned skin that can safely be included in an island flap. Eighty male Wistar rats were divided into four groups, with varying extent of burning of the right epigastric flap site: group 1, 50% superficially burned; group 2, 100% superficially burned; group 3, 50% deeply burned; and group 4, 100% deeply burned. In each group the left epigastric flaps served as controls. The superficially burned flaps in groups 1 and 2 healed at 2-4 weeks, and the deeply burned flaps in groups 3 and 4 healed at 4-6 weeks postoperatively. In all cases hair grew on the burned flap sites, and the flaps healed in such a way that they were almost impossible to distinguish, even after the hair was shaved at week 8. It was observed that the superficially burned flaps healed perfectly without scarring, but small portions of the deeply burned flaps developed scars. In conclusion, superficially and deeply burned island flaps survived completely in this animal model, even when the entire flap surface was burned. In the future, under appropriate conditions the transfer of partial-thickness burned tissue as flaps may provide a good alternative for reconstruction of the acute burn wound.

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Tissue Expansion for Burn Reconstruction

Borman¹,

Uysal

2010

Color Atlas of Burn Reconstructive Surgery

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Reliability of Island Flaps Raised After Superficial and Deep Burn Injury

Cited by 13 publications

References 0 publications

Rat models of skin wound healing: A review

Rat models of skin wound healing: A review

The use of superficial and deep partial-thickness burned tissue for flap fabrication

Tissue Expansion for Burn Reconstruction

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