Background
We prospectively assessed anxiety, depression, and behavior in children with standard risk acute lymphoblastic leukemia (SR-ALL) during the first year of therapy and identified associated risk factors.
Methods
Cohort study of 159 children (age 2–9.99 years) with SR-ALL enrolled on Children’s Oncology Group protocol AALL0331 at 31 sites. Parents completed the Behavior Assessment System for Children, the Family Assessment Device-GF, and the Coping Health Inventory for Parents at ~1, 6 and 12 months after diagnosis.
Results
Overall, mean scores for anxiety, depression, aggression and hyperactivity were similar to population norms. However, more children scored in the at risk/clinical range for depression than the expected 15% at one month (21.7%, p=0.022), six months (28.6%, p<0.001), and twelve months (21.1%, p=0.032). For anxiety, more scored in the at risk/clinical range at one month (25.2% vs. 15%, p=0.001), but then reverted to expected levels. In adjusted analysis, unhealthy family functioning predicted anxiety (OR=2.24, p=0.033) and depression (OR=2.40, p=0.008). Hispanic ethnicity was associated with anxiety (OR=3.35, p=0.009). Worse physical functioning (p=0.049), unmarried parents (p=0.017), and less reliance on social support (p=0.004) were associated with depression. Emotional distress at one month predicted anxiety (OR=7.11, p=0.002) and depression (OR=3.31, p=0.023) at twelve months.
Conclusion
Anxiety is a significant problem in a subpopulation of SR-ALL patients immediately after diagnosis, while depression remains a significant problem for at least one year. Children of Hispanic ethnicity or with unhealthy family functioning may be particularly vulnerable. These data suggest that clinicians should screen for anxiety and depression throughout the first year of therapy.