Reliability of Cyclotorsion measurements using Scanning Laser Ophthalmoscopy imaging in healthy subjects: the CySLO study

Lengwiler, Fabian; Rappoport, Daniel; Jaggi, Gregor P.; Landau, Klara; Traber, Ghislaine L.

doi:10.1136/bjophthalmol-2017-310396

Cited by 13 publications

(21 citation statements)

References 16 publications

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“…Normative values of the DFA reported in the literature ranging from 0° to 13° and are not related to the age and refractive error. 15,19,20 The mean DFA obtained by Cyclocheck ® application was 6.39° ± 2.72° (range from −0.40° to 12.76°) in 131 healthy volunteers. Our results are in accordance with the data presented in previous studies.…”

Section: Discussionmentioning

confidence: 95%

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Objective cyclodeviation measurement in normal subjects by means of Cyclocheck^® application

Simiera

Ordon

Loba

2020

European Journal of Ophthalmology

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Purpose: To evaluate the range of cyclodeviation in normal individuals by means of Cyclocheck® application recently designed by the authors and freely available at www.cyclocheck.com . Methods: Healthy subjects with normal muscle balance, best-corrected visual acuity of ⩾0.8, and stereopsis on Randot charts of ⩽100 s of arc were included in the study. Two separate digital fundus photographs were taken of each eye of every patient. The disk-foveal angle was calculated using the Cyclocheck® application. The average result of the disk-foveal angle measurements were considered for data analysis. Results: A total of 131 patients met inclusion criteria for the study population. The mean value of the disk-foveal angle in the whole study group (both right and left eye) was 6.39° ± 2.72° with 5.26° ± 2.56° (range from −0.4° to 12.55°) in the right eye and 7.52° ± 2.39° (range from 1.25° to 12.76°) in the left eye. The mean value of the disk-foveal angle of the left eye was greater by 2.26° than that of the right eye. Conclusion: Cyclocheck® software allows easy assessment of cyclodeviation. Normal individuals present with a positive value of the disk-foveal angle with a certain spread of the results. The analysis of obtained measurements revealed a significant asymmetry between both eyes with the left eye being more excyclodeviated in an otherwise orthotropic population, which remains a subject for further investigations.

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Section: Discussionmentioning

confidence: 95%

“…Shin et al 14 found the mean DFA of 5.13° ± 2.79° in 150 normal individuals. Analyzing torsion with scanning laser ophthalmoscope (SLO), Rohrschneider 19 and Lengwiler et al 20 noted the mean DFA of −5.6° ± 3.3° and 6.6° ± 2.8°, respectively.…”

Section: Discussionmentioning

confidence: 99%

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck^® application

Simiera

Ordon

Loba

2020

European Journal of Ophthalmology

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“…OCT is an emerging technique for objective cyclotorsion assessment based on the scanning laser ophthalmoscopy fundus image. Lengwiler et al [9] showed a high inter-(rho = 0.88) and intra-rater (rho = 0.95) reliability of the FPA in healthy subjects measured with the in-built algorithm of the Heidelberg Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). However, further clinical studies in patients with ocular motor diseases are needed to validate OCT in this context.…”

Section: Discussionmentioning

confidence: 99%

“…However, the latter is invasive and not routinely applicable in daily clinical practice. Optical coherence tomography (OCT) is on the horizon as another objective measurement tool [9]. Subjective and objective cyclotorsion measurements may vary widely and are often not consistent [3,4].…”

Section: Inter-rater Reliability Of Cyclotorsion Measurements Using Fmentioning

confidence: 99%

Inter-Rater Reliability of Cyclotorsion Measurements Using Fundus Photography

Dysli

Kanku

Traber

2018

Klin Monatsbl Augenheilkd

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“…Additionally, the system is prepared to be merged with other imaging modalities such as SLO or/and OCT that can provide high-resolution imaging of the subject's retina and additional information such as cyclotorsion measurement [54]. Adding a module with an extra pair of scanners to the imaging modalities connected to FET via a dichroic mirror inserted, for example, between M5 and L6 opens up the possibility for active correction of the acquired images of the eye.…”

Section: Optical Setupmentioning

confidence: 99%

High-resolution, ultrafast, wide-field retinal eye-tracking for enhanced quantification of fixational and saccadic motion

Bartuzel¹,

Wrobel²,

Tamborski³

et al. 2020

Biomed. Opt. Express

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We introduce a novel, noninvasive retinal eye-tracking system capable of detecting eye displacements with an angular resolution of 0.039 arcmin and a maximum velocity of 300°/s across an 8°span. Our system is designed based on a confocal retinal imaging module similar to a scanning laser ophthalmoscope. It utilizes a 2D MEMS scanner ensuring high image frame acquisition frequencies up to 1.24 kHz. In contrast with leading eye-tracking technology, we measure the eye displacements via the collection of the observed spatial excursions for all the times corresponding a full acquisition cycle, thus obviating the need for both a baseline reference frame and absolute spatial calibration. Using this approach, we demonstrate the precise measurement of eye movements with magnitudes exceeding the spatial extent of a single frame, which is not possible using existing image-based retinal trackers. We describe our retinal tracker, tracking algorithms and assess the performance of our system by using programmed artificial eye movements. We also demonstrate the clinical capabilities of our system with in vivo subjects by detecting microsaccades with angular extents as small as 0.028°. The rich kinematic ocular data provided by our system with its exquisite degree of accuracy and extended dynamic range opens new and exciting avenues in retinal imaging and clinical neuroscience. Several subtle features of ocular motion such as saccadic dysfunction, fixation instability and abnormal smooth pursuit can be readily extracted and inferred from the measured retinal trajectories thus offering a promising tool for identifying biomarkers of neurodegenerative diseases associated with these ocular symptoms.

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Reliability of Cyclotorsion measurements using Scanning Laser Ophthalmoscopy imaging in healthy subjects: the CySLO study

Abstract: NCT02631369, Results.

Cited by 13 publications

References 16 publications

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck^® application

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck^® application

Inter-Rater Reliability of Cyclotorsion Measurements Using Fundus Photography

High-resolution, ultrafast, wide-field retinal eye-tracking for enhanced quantification of fixational and saccadic motion

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Reliability of Cyclotorsion measurements using Scanning Laser Ophthalmoscopy imaging in healthy subjects: the CySLO study

Abstract: NCT02631369, Results.

Cited by 13 publications

References 16 publications

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck® application

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck® application

Inter-Rater Reliability of Cyclotorsion Measurements Using Fundus Photography

High-resolution, ultrafast, wide-field retinal eye-tracking for enhanced quantification of fixational and saccadic motion

Contact Info

Product

Resources

About

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck^® application

Objective cyclodeviation measurement in normal subjects by means of Cyclocheck^® application