Reliability of Clinician Erythema Assessment grading scale

Tan, Jerry; Liu, Hong; Leyden, James J.; Leoni, Matthew

doi:10.1016/j.jaad.2014.05.044

Cited by 87 publications

(101 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar ICCs were found by Tan et al . in a study for redness in rosacea with an overall inter‐ and intraobserver reliability of 0·601 and 0·658, respectively …”

Section: Discussionmentioning

confidence: 99%

Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts

et al. 2017

View full text Add to dashboard Cite

SummaryBackground The clinical appearance of cutaneous warts is highly variable and not standardized. Objectives To develop and validate a reproducible clinical tool for the standardized assessment of cutaneous warts to distinguish these lesions accurately. Methods Nine morphological characteristics were defined and validated regarding intra-and interobserver agreement. Based on literature and semistructured interviews, a systematic dichotomous assessment tool, the Cutaneous WARTS (CWARTS) diagnostic tool was developed. The validation consisted of two independent parts performed with photographs from the recent WARTS-2 trial. In part A, the CWARTS diagnostic tool was tested by 28 experienced physicians who assessed photographs of 10 different warts to investigate interobserver concordance. In part B, morphological characteristics were validated by masked and independent scoring of 299 photographs by six different observers. Part B also entailed reassessment of the photographs after at least 1 week. The primary outcome measurement was the intraclass correlation coefficient (ICC). Results Presence of black dots (capillary thrombosis) had the greatest ICC (0Á85) for interobserver agreement in part A, followed by arrangement (0Á65), presence of border erythema (0Á64) and sharpness of the border (0Á60). In part B, results were similar for interobserver agreement with presence of black dots having the highest ICC (0Á68), followed by border erythema (0Á64), arrangement (0Á58) and colour (0Á55). For intraobserver agreement, presence of black dots had the highest agreement (0Á70), followed by presence of border erythema (0Á694) and colour (0Á59). Conclusions Wart phenotype can be reliably assessed using the CWARTS diagnostic tool.

show abstract

“…Similar ICCs were found by Tan et al . in a study for redness in rosacea with an overall inter‐ and intraobserver reliability of 0·601 and 0·658, respectively …”

Section: Discussionmentioning

confidence: 99%

Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The sites were then covered with 3M Tegaderm HP Transparent Film Dressing (3M, St. Paul, MN), custom cut to size. After 48 hours, the dressings were removed and the sites were graded on the amount and severity of skin irritation using the Clinician Erythema Assessment scale (score of 0–4, see Table ) described by Tan . The amount of irritation was measured as a percentage of the 25 mm 2 round area of challenge given by the Hill Top Chamber.…”

Section: Methodsmentioning

confidence: 99%

In vivo methods to evaluate a new skin protectant for loss of skin integrity

Been¹,

Bernatchez²,

Conrad‐Vlasak³

et al. 2016

Wound Repair Regeneration

View full text Add to dashboard Cite

A new skin protectant was developed for use on conditions involving partial-thickness skin loss such as severe incontinence-associated dermatitis. This new formulation is based on a cyanoacrylate chemistry designed to polymerize in situ and create a breathable film able to protect the skin surface from external irritants. This film provides an environment favorable for healing to occur beneath the film. To evaluate the characteristics of the novel chemistry, we devised a preclinical testing strategy comprising three different animal models. The data from all three models was considered collectively to create an overall assessment of effectiveness. A guinea pig model was used to evaluate the barrier efficacy of the new product in protecting intact skin from irritation. A porcine partial-thickness wound model was used to evaluate the efficacy of the product in helping control minor bleeding and exudate. A similar model was also used to assess the process of reepithelialization in the continued presence of an irritant. In the first model, untreated sites had 8.5 times more irritation than sites covered with the new product (p < 0.001). In the second model, a single application of the new product successfully attached to intact peri-wound skin and to denuded, weepy skin. It significantly reduced the amount of fluid weeping from the wounds (p 0.001) and continued to perform throughout a 96 hours experiment. In the third model, the percent of reepithelialization was significantly greater for the wounds covered with the new product than for the control wounds (p 5 0.003; on average, 18.3% greater, with a 95% confidence interval of 9.2% to 27.5%). These results suggest that the new skin protectant protects intact and denuded skin from irritants and provides an environment favorable to healing, offering promise for the management of various conditions involving loss of epidermis. Wound healing is a complex biological process with several steps involved to restore skin integrity (hemostasis, inflammation, granulation tissue formation, and remodel-ing). The biological events involved and how they can be modulated using current knowledge and technology have been recently reviewed by Wong et al. 1 The context of the wound impacts the sequence of events that will follow and the successful resolution of the wound. A variety of products are available to manage wounds. Dressings are typically used for acute (surgical or traumatic) and chronic wounds (recently reviewed by Sood et al. 2); however, severe skin damage such as that seen in incontinence-associated dermatitis (IAD) requires a different approach due to the location on the body and the necessity for frequent cleaning caused by incontinence episodes. In mild cases of IAD (skin is red and macerated but epidermis is still present), barrier films can be used. These products are applied as liquids, either in a spray formulation, a wipe, or a wand applicator, and polymerize to form a film in situ and protect the skin. In severe cases of IAD, however , the epidermis is breached...

show abstract

“…The trials included a total of 553 men and women with rosacea with fewer than three facial inflammatory lesions, and moderate–severe erythema according to both Clinician's Erythema Assessment and Patient's Self Assessment scales (i.e. a score of at least 3 on both these 5-point scales) 10–12. A wash-out period was mandatory for subjects receiving prescription medicines for inflammatory conditions, rosacea or acne 11.…”

Section: What Is Brimonidine?mentioning

confidence: 99%

Brimonidine for erythema caused by rosacea

2014

DTB

View full text Add to dashboard Cite

show abstract

Reliability of Clinician Erythema Assessment grading scale

Cited by 87 publications

References 13 publications

Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts

Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts

In vivo methods to evaluate a new skin protectant for loss of skin integrity

Brimonidine for erythema caused by rosacea

Contact Info

Product

Resources

About