Reliability of best-estimate diagnosis in genetic linkage studies of major psychoses: results from the Quebec pedigree studies

Maziade, Michel; Ma, Ruijuan; Jp, Fournier; Cliche, D.; Mérette, Chantal; Caron, Catherine; Garneau, Y.; Montgrain, N; Shriqui, Christian L.; Dion, Catherine

doi:10.1176/ajp.149.12.1674

Cited by 129 publications

(24 citation statements)

References 56 publications

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“…As described previously (e.g., Kiss et al, 2007; Tamás et al, 2007), caseness for each proband was established during the original study via a stringent procedure that included standardized psychiatric diagnostic evaluations (involving the youth and a parent informant) by trained interviewers (child psychiatrists and psychologists), each of whom generated DSM-IV mood-disorder diagnoses, and a final best-estimate diagnosis (Maziade et al, 1992). DSM-IV diagnoses were based on the ISCA-D, a semi-structured interview derived from the ISCA (Sherrill & Kovacs, 2000), which has been described in detail in previous publications (Baji et al, 2009; Kiss et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

Bylsma

Yaroslavsky

Rottenberg

et al. 2015

Biological Psychology

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Cardiac autonomic balance (CAB) indexes the ratio of parasympathetic to sympathetic activation (Berntson, Norman, Hawkley, & Cacioppo, 2008), and is believed to reflect overall autonomic flexibility in the face of environmental challenges. However, CAB has not been examined in depression. We examined changes in CAB and other physiological variables in 179 youth with a history of juvenile onset depression (JOD) and 161 healthy controls, in response to two psychological (unsolvable puzzle, sad film) and two physical (handgrip, and forehead cold pressor) challenges. In repeated measures analyses, controls showed expected reductions in CAB for both the handgrip and unsolvable puzzle, reflecting a shift to sympathetic relative to parasympathetic activation. By contrast, JOD youth showed increased CAB from baseline for both tasks (ps<.05). No effects were found for the forehead cold pressor or sad film tasks, suggesting that CAB differences may arise under conditions requiring greater attentional control or sustained effort.

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Section: Methodsmentioning

confidence: 99%

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

Bylsma

Yaroslavsky

Rottenberg

et al. 2015

Biological Psychology

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“…Briefly, proband youth were recruited from 23 child mental health and guidance facilities across Hungary, along with probands’ siblings within 3 years of age. All subjects underwent a stringent assessment procedure that included: a standardized psychiatric diagnostic evaluation using a semistructured interview (each involving the child and a parent informant) by trained interviewers who generated DSM IV diagnoses and independent verification of the diagnoses by pairs of trained child psychiatrists, via “best estimate” consensus (Maziade et al, 1992). Diagnoses of the probands and siblings in the current study also were subjected to consensus reviews by senior clinicians.…”

Section: Methodsmentioning

confidence: 99%

Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression

2014

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Can atypical patterns of parasympathetic nervous system activity serve as endophenotypes for depression? Using respiratory sinus arrhythmia (RSA) as an index of parasympathetic nervous system function, we examined this question in two studies: one involving mothers with and without depression histories and their offspring (at high and low risk for depression, respectively), and a further study of adolescent sibling pairs concordant and discordant for major depression. In both studies, subjects were exposed to sad mood induction; subjects’ RSA was monitored during rest periods and in response to the mood induction. We used Gottesman and Gould’s (2003) criteria for an endophenotype and a priori defined “atypical” and “normative” RSA patterns (combinations of resting RSA and RSA reactivity). We found that atypical RSA patterns (a) predicted current depressive episodes and remission status among women with histories of juvenile onset depression and healthy controls, (b) predicted longitudinal trajectories of depressive symptoms among high- and low-risk young offspring, (c) were concordant across mothers and their juvenile offspring, (d) were more prevalent among never-depressed youth at high risk for depression than their low-risk peers, and (e) were more concordant across adolescent sibling pairs in which both versus only one had a history of major depression. Thus, the results support atypical RSA patterns as an endophenotype for depression. Possible mechanisms by which RSA patterns increase depression risk and their genetic contributors are discussed.

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“…As described previously (20–21), caseness for each proband was established via two standardized psychiatric diagnostic evaluations by different interviewers about 1 month apart, followed by independent verification of the diagnosis by the consensus best-estimate diagnostic procedure (22). We used the Interview Schedule for Children and Adolescents - Diagnostic Version (ISCA-D), a semi-structured psychiatric interview (for more detail, see 20), which is an extension and modification of an earlier semi-structured Interview (23); parent and child each separately served as informants.…”

Section: Methodsmentioning

confidence: 99%

The Association Between Major Depressive Disorder in Childhood and Risk Factors for Cardiovascular Disease in Adolescence

Rottenberg

Yaroslavsky

Carney

et al. 2014

Psychosomatic Medicine

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Objective Depression in adults is associated with risk factors for cardiovascular disease (CVD). It is unclear, however, when the association between clinical depression and cardiac risk factors develops, or how early in life this association can be detected. Methods In an ongoing study of pediatric depression, we compared CVD risk factors, including smoking, obesity, physical activity level, sedentary behavior, and parental history of CVD, across three samples of adolescents: probands with established histories of childhood-onset major depressive disorder (MDD; N=210), never-depressed siblings of probands (N=195), and controls with no history of any major psychiatric disorder (N=161). Results When assessed during adolescence, 85% of the probands were not in a major depressive episode. Nevertheless, at that assessment, probands had a higher prevalence of regular smoking ([odds ratio [OR] 12.54, 95% confidence interval [CI] = 4.36–36.12) and were less physically active than controls (OR .59, CI = .43–.81) and siblings (OR .70, CI = .52–.94), and had a higher rate of obesity than did controls (OR 3.67, CI = 1.42–9.52). Parents of probands reported high rates of CVD (significantly higher than did parents of controls), including myocardial infarction and CVD-related hospitalization (ORs 1.62–4.36; CIs = 1.03–15.40). Differences in CVD risk factors between probands and controls were independent of parental CVD. Conclusions Major depression in childhood is associated with an unfavorable CVD risk profile in adolescence, and risks for pediatric depression and CVD may coincide in families. Effective prevention and treatment of childhood depression may be a means to reduce the incidence of adult CVD.

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Reliability of best-estimate diagnosis in genetic linkage studies of major psychoses: results from the Quebec pedigree studies

Cited by 129 publications

References 56 publications

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges

Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression

The Association Between Major Depressive Disorder in Childhood and Risk Factors for Cardiovascular Disease in Adolescence

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