Reliability of beat-to-beat blood pressure variability in older adults

Lohman, Trevor; Sible, Isabel J.; Shenasa, Fatemah; Engstrom, Allison C.; Kapoor, Arunima; Alitin, John Paul M.; Gaubert, Aimee; Thayer, Julian F.; Ferrer, Farrah; Nation, Daniel A.

doi:10.21203/rs.3.rs-4190135/v1

Cited by 2 publications

(2 citation statements)

References 66 publications

(88 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These static pressures are used to calibrate the continuous BP monitor using the Caretaker® system (Biopac®). After calibration, continuous BP was monitored during MRI for 7 minutes and further data processing was performed as previously described 42 .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults

Lohman,

Shenasa,

Sible

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Blood pressure variability (BPV) and arterial stiffness are age-related hemodynamic risk factors for neurodegenerative disease, but it remains unclear whether they exert independent or interactive effects on brain health. When combined with high inter-beat BPV, increased intra-beat BPV indicative of arterial stiffness could convey greater pressure wave fluctuations deeper into the cerebrovasculature, exacerbating neurodegeneration. This interactive effect was studied in older adults using multiple markers of neurodegeneration, including medial temporal lobe (MTL) volume, plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP). Older adults (N=105) without major neurological or systemic disease were recruited and underwent brain MRI and continuous BP monitoring to quantify inter-beat BPV through systolic average real variability (ARV) and intra-beat variability through arterial stiffness index (ASI). Plasma NfL and GFAP were assessed. The interactive effect of ARV and ASI on MTL atrophy, plasma NfL, and GFAP was studied using hierarchical linear regression. Voxel-based morphometry (VBM) was used to confirm region-of-interest analysis findings. The interaction between higher ARV and higher ASI was significantly associated with left-sided MTL atrophy in both the region-of-interest and false discovery rate-corrected VBM analysis. The interactive effect was also significantly associated with increased plasma NfL, but not GFAP. The interaction between higher ARV and higher ASI is independently associated with increased neurodegenerative markers, including MTL atrophy and plasma NfL, in independently living older adults. Findings could suggest the increased risk for neurodegeneration associated with higher inter-beat BPV may be compounded by increased intra-beat variability due to arterial stiffness.

show abstract

Section: Methodsmentioning

confidence: 99%

“…ARV calculates the average of absolute changes between consecutive blood pressure readings and is calculated as: Where n represents the number of blood pressure readings obtained during continuous blood pressure monitoring and k represents the beat index of the readings as previously described 11,42 .…”

Section: Methodsmentioning

confidence: 99%

The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults

Lohman,

Shenasa,

Sible

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults

Lohman,

Sible,

Engstrom

et al. 2024

GeroScience

View full text Add to dashboard Cite

Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory decline in older adults. Beat-to-beat BPV may represent a more reliable and efficient tool for prospective risk assessment, but it is unknown whether beat-to-beat BPV is similarly associated with hippocampal neurodegeneration, or with plasma markers of neuroaxonal/neuroglial injury. Independently living older adults without a history of dementia, stroke, or other major neurological disorders were recruited from the community (N = 104; age = 69.5 ± 6.7 (range 55–89); 63% female). Participants underwent continuous blood pressure monitoring, brain MRI, venipuncture, and cognitive testing over two visits. Hippocampal volumes, plasma neurofilament light, and glial fibrillary acidic protein levels were assessed. Beat-to-beat BPV was quantified as systolic blood pressure average real variability during 7-min of supine continuous blood pressure monitoring. The cross-sectional relationship between beat-to-beat BPV and hippocampal volumes, cognitive domain measures, and plasma biomarkers was assessed using multiple linear regression with adjustment for demographic covariates, vascular risk factors, and average systolic blood pressure. Elevated beat-to-beat BPV was associated with decreased left hippocampal volume (P = .008), increased plasma concentration of glial fibrillary acidic protein (P = .006), and decreased memory composite score (P = .02), independent of age, sex, average systolic blood pressure, total intracranial volume, and vascular risk factor burden. In summary, beat-to-beat BPV is independently associated with decreased left hippocampal volume, increased neuroglial injury, and worse memory ability. Findings are consistent with prior studies examining visit-to-visit BPV and suggest beat-to-beat BPV may be a useful marker of hemodynamic brain injury in older adults.

show abstract

Reliability of beat-to-beat blood pressure variability in older adults

Cited by 2 publications

References 66 publications

The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults

The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults

Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults

Contact Info

Product

Resources

About