This paper reviews the main optimization approaches and design frameworks found in the literature for the synthesis of power system architectures for More Electric Aircraft (MEA). System-and network-engineering are the main interdisciplinary fields that have been used to conceive new highly reliable architectural solutions that demands both disruptive technologies utilization and appropriate complexity management. Being safety the most important feature, it is imperative to explore the benefits these design approaches can offer in the formulation of a MEA power system design problem considering safety and reliability requirements.