Wind loads are very important in the design of tall buildings as often the load combinations containing the wind load govern the design. As for reliability, however, because of the higher inherent uncertainty in the wind load in comparison to the gravity load, safety indices decrease as the ratio of wind load to gravity load increases. The safety indices in RC columns depend on the nominal wind to gravity load ratios. Due to the interaction between bending moment and axial force, a single ratio cannot be defi ned, because the eccentricity is not similar for wind and gravity loads. In this paper, the ratio of wind to gravity loads is considered separately for axial force and bending moments. Unlike conventional approach, here it is assumed that the wind and gravity loads' eccentricities are not equal, and the fi nal load eccentricity used in either the design or the reliability analysis is a function of applied loads. The results demonstrate that the sensitivity of RC columns' safety indices to bending moment ratios is higher than that of axial force ratios. Furthermore, the variation of RC columns' safety indices with a low rebar percentage is very different from RC columns with high rebar percentages.