Reliability assessment of soluble c-erb B-2 concentrations in the saliva of healthy women and men

Streckfus, Charles F.; Bigler, Lenora; Dellinger, Tracy; Dai, X.; Cox, William; McArthur, A. Norman; Kingman, Albert; Thigpen, J.T.

doi:10.1067/moe.2001.111758

Cited by 39 publications

(57 citation statements)

References 13 publications

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“…The soluble C-erbB-2 receptor protein levels have been detected in serum, nipple aspirates and saliva (7). It has been reported that the assay of salivary C-erbB-2 protein is reliable and might have potential use in the initial detection and follow up screening of breast cancer (8). CA15-3, a high-molecular-mass mucin-like glycoprotein, is expressed at the luminal surface of most secretary epithelial (9).…”

Section: Introductionmentioning

confidence: 99%

Oral contraceptive use and salivary C-erbB-2, CEA and CA15-3 in healthy women: A Case-Control Study

Vahedi¹,

Abdollahzadeh²,

Vaziri³

et al. 2011

Med Oral

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Objectives: Oral contraceptives (OCP) are highly effective, safe and widely used. Higher exposure to endogenous and exogenous estrogens is generally thought to increase the risk of breast cancer. Therefore, this study was conducted to determine if oral contraceptive use affected the expression of CA 15-3, CEA and C-erb B-2 in the saliva of healthy women. Study design: The participants consisted of 87 healthy women (43 controls and 44 using oral contraceptives) ranging in age from 20 to 54 years. The volunteers participated by giving one -time stimulated whole saliva samples. Then the samples were analysed for CA 15-3, CEA and C-erb B-2 concentrations. Results: The student t-test was used to compare group means for variables with comparable variability. The mean of C-erb B-2, CEA, and CA 15-3 concentrations (in the case and control groups) was (1.93, 1.70), (34.46, 31.62) and (12.58, 16.19) respectively. These differences were not statistically significant. Conclusions: Our findings suggest that the levels of the cancer biomarkers C-erb B-2, CEA and CA 15-3 were not affected by increased levels of estrogens in the body.

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Section: Introductionmentioning

confidence: 99%

Oral contraceptive use and salivary C-erbB-2, CEA and CA15-3 in healthy women: A Case-Control Study

Vahedi¹,

Abdollahzadeh²,

Vaziri³

et al. 2011

Med Oral

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show abstract

“…From the analysis in saliva, the soluble fragment of the oncogene c-erbB-2, a prognostic marker for breast cancer, as well as the antigen for cancer were significantly higher in the saliva and serum of women diagnosed with cancer than that observed in a control group of healthy women and patients with benign tumors group, indicating that the saliva test for this oncogene is sensitive and reliable, and it is potentially useful in the early detection and monitoring of screening for breast cancer [56].…”

Section: Malignancymentioning

confidence: 97%

Salivary Diagnostics, Current Reality and Future Prospects

Silva¹,

Silva²,

Ferreira³

et al. 2015

Emerging Trends in Oral Health Sciences and Dentistry

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“…1 Sometimes the diagnostic test is based on a continuous measurement and the patient classified as having some disease if the level of the measurement exceeds (or is less than) a particular value, the cut-off value. For example, there is a suggestion (Streckfus et al, 2001) that it might be possible to use the concentrations of the salivary protein c-erbB-2 as a marker for the initial detection and follow-up screening for the recurrence of breast cancer in men and women. 2 The cut-off is usually the upper (or the lower) limit of the reference range for that measurement.…”

Section: N B R I E Fmentioning

confidence: 99%

“…For example, there is a suggestion (Streckfus et al, 2001) that it might be possible to use the concentrations of the salivary protein c-erbB-2 as a marker for the initial detection and follow-up screening for the recurrence of breast cancer in men and women. 2 The cut-off is usually the upper (or the lower) limit of the reference range for that measurement. The reference range is the range of values which includes a large proportion (usually 95%) of the healthy (disease-free) individuals in the population.…”

Section: N B R I E Fmentioning

confidence: 99%