Reliability and validity of the brief dimensional apathy scale

Radaković, Ratko; Gray, Debbie; Dudley, Kaitlin; Mioshi, Eneida; Dick, D J; Melchiorre, Giulia; Gordon, H.; Newton, Judith; Colville, Shuna; Pal, Suvankar; Chandran, Siddharthan; Abrahams, Sharon

doi:10.1093/arclin/acaa002

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…Emerging functional modalities, such as magnetoencephalography or spectral EEG have also confirmed widespread extra-motor dysfunction and as these technologies develop they are likely to contribute important additional insights (239)(240)(241)(242)(243). The majority of imaging studies in ALS explored the underpinnings of the most commonly affected neuropsychological domains (233,244), such as the substrate of verbal fluency deficits, executive dysfunction, and behavioral impairment, but with the recognition of the relatively high prevalence of impairments in social cognition, memory deficits, and of apathy, the focus of imaging studies is likely to gradually shift (12,(245)(246)(247)(248)(249). Imaging changes in ALS are typically solely interpreted based on genetic and clinical profiles, and seldom correlated with other markers such biofluid markers (250)(251)(252).…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging

et al. 2021

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Frontotemporal involvement has been extensively investigated in amyotrophic lateral sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease (MND) phenotypes such as primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), spinal muscular atrophy (SMA), spinal bulbar muscular atrophy (SBMA), post poliomyelitis syndrome (PPS), and hereditary spastic paraplegia (HSP). This review focuses on insights from structural, metabolic, and functional neuroimaging studies that have advanced our understanding of extra-motor disease burden in these phenotypes. The imaging literature is limited in the majority of these conditions and frontotemporal involvement has been primarily evaluated by neuropsychology and post mortem studies. Existing imaging studies reveal that frontotemporal degeneration can be readily detected in ALS and PLS, varying degree of frontotemporal pathology may be captured in PMA, SBMA, and HSP, SMA exhibits cerebral involvement without regional predilection, and there is limited evidence for cerebral changes in PPS. Our review confirms the heterogeneity extra-motor pathology across the spectrum of MNDs and highlights the role of neuroimaging in characterizing anatomical patterns of disease burden in vivo. Despite the contribution of neuroimaging to MND research, sample size limitations, inclusion bias, attrition rates in longitudinal studies, and methodological constraints need to be carefully considered. Frontotemporal involvement is a quintessential clinical facet of MND which has important implications for screening practices, individualized management strategies, participation in clinical trials, caregiver burden, and resource allocation. The academic relevance of imaging frontotemporal pathology in MND spans from the identification of genetic variants, through the ascertainment of presymptomatic changes to the design of future epidemiology studies.

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Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging

et al. 2021

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“…Variable awareness of, or insight into, behavior problems and/or changes is characteristic of frontotemporal dementia associated with ALS ( 33 ), which may influence patients' self-ratings. As a result, the informant/caregiver-rated DAS was used to design the informant/caregiver-rated brief DAS ( 34 , 35 ), a short and comprehensive apathy subtype measure with a supplemental awareness assessment. Future research should look to translate and utilize the brief DAS clinically to help detect motivational problems.…”

Section: Discussionmentioning

confidence: 99%

“…The convenience recruitment method utilized may also have biased the sample and, as with other apathy research, may have introduced a volunteerism bias. However, this is unlikely to impact the Spanish DAS validation results as previous DAS validation research has used similar recruitment methodology ( 16 , 21 , 35 ). Furthermore, there was an age difference between the ALS patient group and the control group.…”

Section: Discussionmentioning

confidence: 99%

Spanish Adaptation of the Dimensional Apathy Scale (DAS) in Amyotrophic Lateral Sclerosis

et al. 2020

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Aim: To adapt, translate, and utilize the Dimensional Apathy Scale (DAS) in Amyotrophic Lateral Sclerosis (ALS) to the Spanish population. Method: We recruited 104 ALS patients (67 of their caregivers) and 49 controls. Participants completed the Spanish-translated DAS, Geriatric Depression Scale- Short form. Patients were also administered the ALS Functional Rating Scale-Revised (ALSFRS-R). Caregivers additionally completed the informant/caregiver-rated Spanish-translated DAS. The DAS was translated to Spanish using a back-translation method. Test-retest and internal consistency reliability were examined. Divergent validity was assessed by comparing the DAS with the depression scale (GDS-15). Principal Component Analysis (PCA) was applied to explore the substructure of the Spanish DAS. Results: The internal consistency reliability of self-rated Spanish DAS was 0.72 and of the informant/caregiver-rated Spanish DAS was 0.84. Correlations between self-rated DAS subscales and GDS-15 were not statistically significant, with a good test-retest reliability. PCA analysis showed a similar substructure to the original DAS. ALS patients had significantly higher Initiation apathy than controls. Additionally, ALS patient informant/caregiver-rated DAS Emotional apathy was significantly higher than the self-rated, with no significant differences observed in the Executive and Initiation subscales. No association was found between DAS and functional impairment using the ALS Functional Rating Scale (ALSFRS-R). Conclusion: The Spanish translation of the DAS is valid and reliable for use in assessing multidimensional apathy in the Spanish population. Availability of the Spanish DAS will allow for future research to explore different apathy subtypes and their impact in ALS and other conditions.

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“…Besides generic instruments available to evaluate multiple neuropsychiatric syndromes in AD, with the Neuropsychiatric Inventory (NPI) being the most frequently used in research and clinical settings [ 40 ], there are tools specifically developed to assess apathy. The latter group includes the Apathy Evaluation Scale (AES) [ 19 , 41 ], the Apathy Inventory [ 42 ], the Lille Apathy Rating Scale [ 43 , 44 ], and the Dimensional Apathy Scale [ 45 , 46 ], among others [ 39 , 47 ].…”

Section: The Concept and Assessment Of Apathymentioning

confidence: 99%

Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches

Teixeira

Gonzales

Souza

et al. 2021

Behavioural Neurology

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Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer’s disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indicator, correlating with the progression of AD. Despite advances in its conceptualization and understanding of its neural basis, there is very limited empirical evidence to support the available strategies for the treatment of apathy in AD. Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. High-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.

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Reliability and validity of the brief dimensional apathy scale

Cited by 9 publications

References 20 publications

Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging

Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging

Spanish Adaptation of the Dimensional Apathy Scale (DAS) in Amyotrophic Lateral Sclerosis

Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches

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