Reliability and Validity of the Beijing Version of the Montreal Cognitive Assessment in the Evaluation of Cognitive Function of Adult Patients with OSAHS

Abstract

BackgroundThe patients with obstructive sleep apnea hypopnea syndrome (OSAHS) tend to develop cognitive deficits, which usually go unrecognized, and can affect their daily life. The Beijing version of the Montreal cognitive assessment (MoCA-BJ), a Chinese version of MoCA, has been used for the assessment of cognitive functions of OSAHS patients in clinical practice. So far, its reliability and validity have not been tested. This study examined the reliability and validity of MoCA-BJ in a cohort of adult OSAHS patients.Methods152 OSAHS patients, ranging from mild, moderate to severe, 49 primary snoring subjects and 40 normal controls were evaluated for cognitive functions by employing both MoCA-BJ and the Mini Mental State Examination (MMSE). Forty of them were re-tested by MoCA-BJ 14 days after the first test. Internal consistency, test-retest reliability, discriminate and concurrent validity of MoCA-BJ were analyzed.ResultsInternal consistency reliability by Cronbach’s alpha was adequate (0.73). Intra-class correlation coefficient (ICC), an measure of test-retest reliability, was 0.87 (P<0.001). The total MoCA-BJ scores were significant higher in normal controls than in OSAHS groups (p<0.05). The performances of visuospatial ability in severe OSAHS group were significantly weaker than in normal controls and primary snoring group. The performances of executive ability in severe OSAHS patients were weaker than in normal controls. An optimal cut-off between normal controls and non-normal subjects was at 26 points (total MoCA score). Moreover, cut-off between non-severe and severe OSAHS was at 2 points on visuospatial subscale. Analysis of the correlation between MoCA total scores and MMSE total scores revealed a statistically significant, though relatively weak, correlation (r=0.41, P<0.05).ConclusionIn conclusion, our study showed that the Beijing version of the MoCA was reliable and stable. The MoCA-BJ was capable of detecting cognitive dysfunction by visuospatial and total MoCA-BJ score.

Patients with chronic insomnia have selective impairments in memory that are modulated by cortisol

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“…This test takes approximately 10 to 15 min to administer, and the total score is 30 points. In China, a score 26 indicates normal cognitive function (Chen et al, 2015;Yu & Huang, 2012).…”

Neuroimaging consequences of cerebral small vessel disease in patients with obstructive sleep apnea–hypopnea syndrome

“…Mounting evidence suggests that OSAHS is associated with neurocognitive impairment (Chen et al, 2015). The auditory P3 is an electrophysiological event associated with attention processes in tasks that require target detection and involve sensory perception (Smart, Segalowitz, Mulligan, & MacDonald, 2014).…”

The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis

“…Pre-dialysis blood tests included measurement of the serum levels of hemoglobin, albumin, calcium, phosphate, and intact parathyroid hormone; the single-pool Kt/V were obtained from all the subjects. (3) memory using the Chinese version of the Auditory Verbal Learning Test for short-delay and long-delay free recall [17] and Rey-Osterrieth Complex Figure (delayed recall test; Chinese version) [18]; (4) language using the Boston Naming Test (the 30-item version) and Category Verbal Fluency Test [19]; and (5) visuospatial function using the Rey-Osterrieth Complex Figure (copy test) [20].…”