Reliability and Reproducibility of Assessment of Corneal Epithelial Thickness by Fourier Domain Optical Coherence Tomography

Prakash, Gaurav; Agarwal, Amar; Mazhari, Anjum Iqbal; Chari, Mathangi; Kumar, Dhivya Ashok; Kumar, Gautam; Singh, Bunty

doi:10.1167/iovs.11-8981

Cited by 53 publications

(46 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results showed a CoR of less than 3.54 μm for normal subjects and 3.78 μm for post-LASIK patients within the central zone (0-2 mm) and the paracentral zone (2-5 mm) for corneal thickness repeatability and reproducibility. This agreed with previous reports using SD-OCT (Table 3) [4,24,40,41]. To the best of our knowledge, this was the first time the repeatability and reproducibility of pachymetric mapping by SD-OCT were assessed over a comprehensive corneal area.…”

Section: Discussionsupporting

confidence: 92%

“…Several reports have showed repeatability and reproducibility results of various OCT systems for corneal pachymetry, which are summarized in Table 3 [4,22,24,40,41,[49][50][51][52]. Our results showed a CoR of less than 3.54 μm for normal subjects and 3.78 μm for post-LASIK patients within the central zone (0-2 mm) and the paracentral zone (2-5 mm) for corneal thickness repeatability and reproducibility.…”

Section: Discussionsupporting

confidence: 58%

“…Improved axial resolution of OCT allows better delineation of both corneal and sublayer interfaces [15][16][17][18]. Spectral-domain OCT (SD-OCT) has improved the acquisition speed and axial resolution [16,[18][19][20][21].…”

mentioning

confidence: 99%

“…These features make it possible to minimize the influence of eye movement during image acquisition and improve the repeatability of pachymetry measurements. Commercial SD-OCT instruments are available for corneal pachymetry [4,[22][23][24]. Most of these commercial SD-OCT systems are limited to a diameter of 6 mm or less for corneal pachymetry measurements [4,[22][23][24].…”

mentioning

confidence: 99%

“…Most of these commercial SD-OCT systems are limited to a diameter of 6 mm or less for corneal pachymetry measurements [4,[22][23][24]. However, a 6-mm-diameter imaging range may not be sufficient to image the peripheral cornea with diseases and surgery plans, such as pellucid and Terrien's marginal degeneration, Intacs implantation, and corneal cross-linking [24][25][26][27][28].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Reliability of Entire Corneal Thickness Mapping in Normal Post-Laser in situ Keratomileusis and Keratoconus Eyes Using Long Scan Depth Spectral Domain Optical Coherence Tomography

Chen

Yang

et al. 2017

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: To investigate the repeatability and reproducibility of mapping the entire corneal thickness using spectral domain optical coherence tomography (SD-OCT). Methods: Thirty normal eyes, 30 post-laser in situ keratomileusis (LASIK) surgery eyes, and 30 keratoconus eyes were analyzed. A custom-built long scan depth SD-OCT device was used to obtain entire corneal images. Ten-millimeter-diameter corneal thickness maps were generated by an automated segmentation algorithm. Intraclass correlation coefficients of repeatability (ICC₁) and reproducibility (ICC₂), and coefficients of repeatability (CoR₁) and reproducibility (CoR₂), were calculated to quantify the precision and accuracy of corneal pachymetry measurements using the Bland-Altman method. Results: For SD-OCT measurements in healthy subjects, CoR₁ and CoR₂ were less than 5.00 and 5.53 μm. ICC₁ and ICC₂ were more than 0.997 and 0.996. For SD-OCT measurements in LASIK patients, CoR₁ and CoR₂ were less than 5.09 and 5.34 μm. ICC₁ and ICC₂ were more than 0.997 and 0.996. For SD-OCT measurements in keratoconus patients, CoR₁ and CoR₂ were less than 11.57 and 10.92 μm. ICC₁ and ICC₂ were more than 0.995 and 0.996. Conclusions: The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.