Reliability and Initial Validation of the Ulcerative Colitis Endoscopic Index of Severity

Travis, Simon; Schnell, Dan; Krzeski, Piotr; Abreu, María T.; Altman, Douglas G.; Colombel, Jean–Frédéric; Feagan, Brian G.; Hanauer, Stephen B.; Lichtenstein, Gary R.; Marteau, Philippe; Reinisch, Walter; Sands, Bruce E.; Yacyshyn, Bruce; Schnell, Patrick; Bernhardt, Christian A.; Mary, Jean‐Yves; Sandborn, William J.

doi:10.1053/j.gastro.2013.07.024

Cited by 380 publications

(306 citation statements)

References 14 publications

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“…For UC, several endoscopic scoring systems have been developed but none were validated until recently [46][47]. In 2012, the UCEIS has been developed and validated [16,17]. UCEIS is rather complex and time consuming, which makes it less attractive for routine use in daily practice [48].…”

Section: Discussionmentioning

confidence: 99%

“…There are a number of endoscopic disease activity scores that assist endoscopists, but few have been properly evaluated and validated in large cohorts. Good examples are the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) for ulcerative colitis (UC) [16,17], the Crohn's Disease Endoscopic Index of Severity (CDEIS) and the Simple Endoscopic Score (SES-CD) for Crohn's disease (CD) [18][19][20]. Practical and commonly used definitions for MH such as "the complete resolution of the visible alteration or lesions" [21], or endoscopic Mayo score ≤ 1 [22] have the disadvantage of higher interobserver variability and limited accuracy [9,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Treatment Targets in Inflammatory Bowel Disease: Current Status in Daily Practice

Römkens

Gijsbers

Kievit³

et al. 2016

JGLD

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Background & Aims: Recently, treatment goals in inflammatory bowel disease (IBD) in clinical trials have shifted from mainly symptom-based to more mucosa-driven. Real world data on treatment priorities are lacking. We aimed to investigate the current practice and most commonly used definitions of IBD treatment targets among Dutch gastroenterologists. Methods: Dutch gastroenterologists were asked to participate in a computer-based nation-wide survey. We asked questions on demographics, opinion and current practice regarding IBD treatment targets. Results: Twenty-four percent (134/556) of the respondents completed the survey. For both Crohn’s disease (CD) (47.3%, 61/129) and ulcerative colitis (UC)(45%, 58/129) the main treatment goal was to achieve and maintain deep remission, defined as clinical, biochemical and endoscopic remission. Seventy-six percent of the participants use mucosal healing (MH) as a potential treatment target for IBD, whereas 22.6% use histological remission. There is no single definition for MH in IBD. The majority use Mayo score ≤ 1 in UC (52%) and ‘macroscopic normal mucosa’ in CD (66%). Conclusion: More stringent and mucosa-driven treatment targets as ‘deep remission’ and ‘mucosal healing’ have found traction in clinical practice. The most commonly used definition for MH in routine practice is endoscopic MAYO score ≤ 1 in UC and ‘macroscopic normal mucosa’ in CD. Abbreviations: CD: Crohn’s disease; CDEIS: Crohn‘s Disease Endoscopic Index of Severity; IBD: Inflammatory Bowel Disease; IBDU: IBD unclassified; IOIBD: International Organization for the Study of Inflammatory Bowel Diseases; MH: Mucosal healing; MMH: Microscopic mucosal healing; PROMS: Patient reported outcome measures; SES-CD: Simple endoscopic score for Crohn’s disease; UC: ulcerative colitis; UCEIS: Ulcerative Colitis Endoscopic Index of Severity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment Targets in Inflammatory Bowel Disease: Current Status in Daily Practice

Römkens

Gijsbers

Kievit³

et al. 2016

JGLD

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“…These results highlight the importance of determining a standardized definition of mucosal healing, which may also be histological. Advantages and disadvantages of each score are available in (Table 1) [8,10,[13][14][15][16][17]. …”

Section: Endoscopic Mucosal Healingmentioning

confidence: 99%

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Auzoux¹,

Boschetti²,

Lahlou³

et al. 2017

J Clin Gastroenterol Hepatol

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In recent decades, the advent of biological therapy has changed the treatment of inflammatory bowel disease (IBD) and has opened new therapeutic endpoints such as mucosal healing (MH). MH incorporated with clinical remission presents a new concept: deep remission, which correlates with a decrease in hospitalization and surgery and improvement in the patient's quality of life. Several techniques can be used to assess mucosal healing such as endoscopy which remains the gold standard. But considerable variations may exist in the interpretation of the definition of mucosal healing which may also be histological or evaluated by radiological or biological methods. Thus, it is important to study mucosal inflammation by endoscopic scores and by new, more sensitive techniques such as videocapsule endoscopy (VCE), magnetic resonance enterography (MRE), chromoendoscopy and confocal laser endomicroscopy (CLE). Biomarkers, such as fecal calprotectin (FC) were also studied in the evaluation of MH and showed positive results. These methods are currently the subject of validation studies.

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“…This score was developed as an index that catches 90% of the variance in the overall assessment of endoscopic severity and is the first validated endoscopic index of severity in UC [15]. Basically, the UCEIS is calculated as the simple sum of three descriptors: vascular pattern (score 0-2), bleeding (score 0-3), and erosions and ulcers (score 0-3) (Table 1) [16].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Ulcerative Colitis Endoscopic Index of Severity, Lichtiger Index and Fecal Calprotectin in Ulcerative Colitis Patients

Rv¹,

Vn²,

Va³

et al. 2017

Intern Med

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Reliability and Initial Validation of the Ulcerative Colitis Endoscopic Index of Severity

Cited by 380 publications

References 14 publications

Treatment Targets in Inflammatory Bowel Disease: Current Status in Daily Practice

Treatment Targets in Inflammatory Bowel Disease: Current Status in Daily Practice

Assessment of Mucosal Healing in Inflammatory Bowel Disease

Correlation between Ulcerative Colitis Endoscopic Index of Severity, Lichtiger Index and Fecal Calprotectin in Ulcerative Colitis Patients

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