Relevant problems of chronic obstructive pulmonary diseases in children

Козлов, В. К.; Лебедько, О А; Пичугина, С. В.; Сиротина-Карпова, М С; Евсеева, Г П; Гандуров, С. Г.

doi:10.20953/1817-7646-2019-3-22-31

Cited by 4 publications

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“…Of particular importance in the aggregate of inflammatory bronchial diseases is the pathology in children, in whom the mortality from pneumonia ranges from 3 to 19% [4]. In recent years, there has been an increase in chronic non-specific inflammatory lung diseases in children [2]. Due to destructive processes occurring in inflammatory bronchial diseases, normal histogenetic processes are often disturbed, leading to lung malformations [1].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional Relationships of Cells in the Bronch in Chronic Inflammation

Anatolyevna¹,

Muinovna²

2023

tajmspr

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Section: Introductionmentioning

confidence: 99%

Morphofunctional Relationships of Cells in the Bronch in Chronic Inflammation

Anatolyevna¹,

Muinovna²

2023

tajmspr

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“…Хронические формы патологии легких и бронхов у детей являются актуальной проблемой педиатрии, их частота в последние годы нарастает, а клинические проявления характеризуются тяжестью течения и ранней инвалидизацией пациентов [1][2][3]. В основе патогенеза большинства хронических неспецифических заболеваний легких (ХНЗЛ) у детей лежит длительно текущий воспалительный процесс, часто приводящий к формированию пневмофиброза в структурно измененной ткани легких и бронхов вследствие врожденных дефектов или других причин [1,4]. Фиброзные изменения в легких (пневмофиброз) -патологический процесс замещения ткани легкого плотной волокнистой соединительной тканью.…”

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Indicators of lung function in children with chronic nonspecific lung diseases with pulmonary fibrosis

Knizhnikova

Евсеева

Polubartseva

et al. 2022

Bûlletenʹ fiziologii i patologii dyhaniâ

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Introduction. The pathogenesis of most chronic nonspecific lung diseases (CNSLD) in children is based on a long-term inflammatory process, often leading to the formation of pulmonary fibrosis in the structurally altered tissue, which requires dynamic monitoring of patients, including the study of lung function.Aim. To assess the indicators of the lung function in children with chronic bronchopulmonary pathology accompanied by pulmonary fibrosis.Materials and methods. 84 children with CNSLD were examined. The main group consisted of 45 children with CNSLD with pulmonary fibrosis (bronchopulmonary dysplasia, congenital malformations of the lungs, chronic bronchitis, and post pneumonia fibrosis). The comparison group consisted of 39 children with CNSLD without pulmonary fibrosis. The average age of children in the study groups was 9,3±0,48 years. The patients underwent multispiral computed tomography of the lungs with a virtual bronchoscopy program and intravenous bolus contrast enhancement. Evaluation of lung function was carried out by spirometry.Results. In patients in remission, the average values of the ventilation capacity of the lungs in both groups were within the predicted values. However, in patients with fibrotic changes, pulmonary dysfunction was detected 2 times more often than in children with CNSLD without pulmonary fibrosis (35.5% and 15.4%, respectively, p<0.05). Restrictive ventilation disorders were diagnosed only in the group of patients with pulmonary fibrosis. In children with pulmonary fibrosis, the risk of reduced ventilation capacity is significantly higher than in children with CNSLD without pulmonary fibrosis (OR=3.04, 95% CI 1.049–8.78).Conclusion. The data obtained can serve as a prerequisite for further development of predicting the nature of the course of the disease, identifying “risk groups” for the development of fibrotic changes for a personalized approach to the treatment and follow-up of patients with CNSLD.

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Genetic testing of allelic variants of PIZ (GLU342Lys, RS28929474) and PIS (GLU264Val, RS17580) of SERPINA1 gene in children with bronchial asthma

et al. 2022

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According to world publications, mutations in the SERPINA1 gene may be a genetic risk factor for severe chronic obstructive pulmonary disease and, consequently, rapid progression of respiratory dysfunction. This disease leads to a decrease in the level of alpha-1-antitrypsin protein. It is inherited by autosomal recessive type, but there are registered cases of codominance. In the absence of treatment, diseases of the respiratory system become chronic and lead to disability in adulthood. Early diagnosis of AAT deficiency is important to prevent complications and reduce mortality among people with this pathology. Due to these factors, genetic testing of SERPINA1 gene mutations in children with chronic lung diseases is appropriate to detect and prevent severe complications, associated with AATD. The aim of this work is to improve the effectiveness of early diagnosis of AAT deficiency in children with bronchial asthma and recurrent obstructive bronchitis by identifying different genotypes and phenotypes of A1AT deficiency, studying their relationship with the clinical course of respiratory diseases in children

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Relevant problems of chronic obstructive pulmonary diseases in children

Cited by 4 publications

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Morphofunctional Relationships of Cells in the Bronch in Chronic Inflammation

Morphofunctional Relationships of Cells in the Bronch in Chronic Inflammation

Indicators of lung function in children with chronic nonspecific lung diseases with pulmonary fibrosis

Genetic testing of allelic variants of PIZ (GLU342Lys, RS28929474) and PIS (GLU264Val, RS17580) of SERPINA1 gene in children with bronchial asthma

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