Relevance of the recombinant lipid transfer protein of Hevea brasiliensis: IgE-binding reactivity in fruit-allergic adults

Rihs, Hans‐Peter; Ruëff, Franziska; Lundberg, María; Rozynek, P.; Barber, Domingo; Scheurer, Stephan; Cisteró-Bahíma, A; Brüning, Thomas; Raulf‐Heimsoth, Monika

doi:10.1016/s1081-1206(10)61094-0

Cited by 24 publications

(8 citation statements)

References 24 publications

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“…For example, the high allergen content in peels and cutin layers of fresh fruits has been proposed to be responsible for transdermal sensitization and peach-induced urticaria [25]. However, sensitization to Hev b 12 was shown to have no clinical relevance in contact allergy to natural rubber latex [26].…”

Section: The Sensitizer Questionmentioning

confidence: 99%

The Role of Lipid Transfer Proteins in Allergic Diseases

Egger

Hauser

Mari

et al. 2010

Curr Allergy Asthma Rep

140

120

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Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are considered true food allergens, and IgE reactivity to LTPs is often associated with severe systemic symptoms. Although Pru p 3 represents the predominant LTP in terms of patients' IgE recognition, the contribution of pollen LTPs in primary sensitization cannot be ruled out. Due to structural homology, LTPs from different allergen sources are generally IgE cross-reactive. However, sensitization profiles among allergic patients are extremely heterogeneous, and individual cross-reactivity patterns can be restricted to a single LTP or encompass many different LTPs. Molecule-based approaches in allergy research and diagnosis are important for better understanding of LTP allergy and could assist clinicians with providing adequate patient-tailored advice.

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Section: The Sensitizer Questionmentioning

confidence: 99%

The Role of Lipid Transfer Proteins in Allergic Diseases

Egger

Hauser

Mari

et al. 2010

Curr Allergy Asthma Rep

140

120

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“…The three native latex allergens were prepared at the Rubber Research Institute in Malaysia [18,19], purified and coupled to streptavidin Immuno-CAP TM as described [20]. All recombinant latex allergens were produced in E. coli in fusion with maltose-binding protein (MBP) [6][7][8][21][22][23]. For this reason, MBP was coupled to a separate ImmunoCAP TM to serve as a control.…”

Section: Native and Recombinant Latex Allergensmentioning

confidence: 99%

Quantitative analysis of immunoglobulin E reactivity profiles in patients allergic or sensitized to natural rubber latex (Hevea brasiliensis)

Raulf‐Heimsoth

Rihs

Rozynek

et al. 2007

Clin Experimental Allergy

108

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SummaryBackground Characterized native and recombinant Hevea brasiliensis (rHev b) natural rubber latex (NRL) allergens are available to assess patient allergen sensitization profiles.Objective Quantification of individual IgE responses to the spectrum of documented NRL allergens and evaluation of cross-reactive carbohydrate determinants (CCDs) for more definitive diagnosis. Methods Sera of 104 healthcare workers (HCW; 51 German, 21 Portuguese, 32 American), 31 spina bifida patients (SB; 11 German, 20 Portuguese) and 10 Portuguese with multiple surgeries (MS) were analysed for allergen-specific IgE antibody (sIgE) to NRL, single Hev b allergens and CCDs with ImmunoCAP TM technology. Results In all patient groups rHev b 5-sIgE concentrations were the most pronounced. Hev b 2, 5, 6.01 and 13 were identified as the major allergens in HCW and combined with Hev b 1 and Hev b 3 in SB. In MS Hev b 1 displayed an intermediate relevance. Different sIgE antibody levels to native Hevea brasiliensis (nHev b) 2 and rHev b 6.01 allowed discrimination of SB with clinical relevant latex allergy vs. those with latex sensitization. Sensitization profiles of German, Portuguese and American patients were equivalent. rHev b 5, 6.01 and nHev b 13 combined detected 100% of the latex-allergic HCW and 80.1% of the SB. Only 8.3% of the sera showed sIgE response to CCDs. Conclusions Hev b 1, 2, 5, 6.01 and 13 were identified as the major Hev b allergens and they should be present in standardized latex extracts and in vitro allergosorbents. CCDs are only of minor relevance in patients with clinical relevant latex allergy. Component-resolved diagnostic analyses for latex allergy set the stage for an allergen-directed immunotherapy strategy.

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“…In an own series, sensitization towards different ns-LTP including Pru p 3 from peach (Prunus persica) was demonstrable in almost all patients with CSA that attended our clinic because of a variety of plant-food allergies [23]. Sensitization towards ns-LTP in these patients might also explain allergic cross-reactions to various alcoholic beverages such as beer and wine [24,25], tobacco [26] and Hevea latex [27,28].…”

Section: Cannabis Sativamentioning

confidence: 80%

Allergy to illicit drugs and narcotics

Swerts

Gasse

Leysen

et al. 2014

Clin Experimental Allergy

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Despite their frequent use, allergy to illicit drugs and narcotics is rarely reported in literature. We present a review of the different classes of drugs of abuse that might be involved in allergies: central nervous system (CNS) depressants (such as cannabis, opioids and kava), CNS stimulants (cocaine, amphetamines, khat and ephedra) and hallucinogens such as ketamine and nutmeg. Diagnosis of drug and narcotic allergy generally relies upon careful history taking, complemented with skin testing eventually along with quantification of sIgE. However, for various reasons, correct diagnosis of most of these drug allergies is not straightforward. For example, the native plant material applied for skin testing and sIgE antibody tests might harbour irrelevant IgE-binding structures that hamper correct diagnosis. Diagnosis might also be hampered due to uncertainties associated with the non-specific histamine releasing characteristics of some compounds and absence of validated sIgE tests. Whether the introduction of standardized allergen components and more functional tests, that is, basophil activation and degranulation assays, might be helpful to an improved diagnosis needs to be established. It is anticipated that due to the rare character of these allergies further validation is although necessary.

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Relevance of the recombinant lipid transfer protein of Hevea brasiliensis: IgE-binding reactivity in fruit-allergic adults

Cited by 24 publications

References 24 publications

The Role of Lipid Transfer Proteins in Allergic Diseases

The Role of Lipid Transfer Proteins in Allergic Diseases

Quantitative analysis of immunoglobulin E reactivity profiles in patients allergic or sensitized to natural rubber latex (Hevea brasiliensis)

Allergy to illicit drugs and narcotics

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