Relevance of platelet serotonergic mechanisms in pregnancy induced hypertension

Gujrati, V. R.; Goyal, Anju; Gaur, S. P. S.; Singh, Neeta; Shanker, K.; Chandravati,

doi:10.1016/0024-3205(94)00735-7

Cited by 16 publications

(8 citation statements)

References 22 publications

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“…Significant low-ionized serum Mg has been documented in hyperthyroid patients. [31] However, the correlation between serum Mg and hypothyroidism is not clear and, in the present work, is not changed significantly.…”

Section: Discussioncontrasting

confidence: 68%

“…[12] Serum Mg in some papers showed a negative correlation with the level of thyroid hormones. Total serum Mg[30] and ionized and bound plasma Mg[31] concentrations were low in hyperthyroid patients. Thyroid hormone affects the glomerular filtration rate, blood flow and tubular sodium transport and has a direct effect on tubular Ca and Mg resorption.…”

Section: Discussionmentioning

confidence: 99%

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Serum Levels of Lipids, Calcium and Magnesium in Women with Hypothyroidism and Cardiovascular Diseases

Al‐Hakeim

2009

J Lab Physicians

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Lipid abnormalities in hypothyroidism contribute to the disproportionate increase in cardiovascular risk. A possible relationship between serum level of magnesium (Mg) and calcium (Ca) and cardiovascular disease was recorded. In this work, the possible correlation between lipid profile components and serum cations Ca and Mg was investigated. Matched healthy women were evaluated in a cross-sectional study. All parameters were measured spectrophotometrically. The results showed a significant decrease (P < 0.05) in high-density lipoprotein-cholesterol (HDL-C), total and ionized Mg in hypothyroid patients in comparing with control group. There was a significant increase (P <0.05) in serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and (LDL-C)/(HDL-C) ratio in hypothyroid patients as compared with control group. However, no correlation was found between the cation levels and lipid profile of the studied groups. It can be concluded that patients with hypothyroidism exhibited elevated atherogenic parameters (TC and LDL-C) and high risk of cardiovascular diseases.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Serum Levels of Lipids, Calcium and Magnesium in Women with Hypothyroidism and Cardiovascular Diseases

Al‐Hakeim

2009

J Lab Physicians

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“…By contrast, in pregnancy-induced hypertension, platelet content of 5-HT is increased and release of 5-HT is reduced (Gujrati et al, 1994) or shown to be unchanged (Jelen et al, 1979). Filshie et al (1992) found that urinary 5-HIAA was not elevated in women with pregnancyinduced hypertension compared with women with normal pregnancy.…”

Section: B Clinical Situationsmentioning

confidence: 97%

Serotonin and Blood Pressure Regulation

et al. 2012

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“…Fifth, free plasma 5-HT levels are increased in experimental and human forms of hypertension [92][93][94][95][96][97][98][99]. Reduced levels of platelet 5-HT and an increased plasma 5-HT are observed in essential hypertensive humans and multiple rat models of hypertension, including cyclosporine A-induced, erythropoietin-induced, pregnancy-induced, and nitric oxide synthase (NOS)-inhibited model [126][127][128][129][130][131][132]. Finally, modifying 5-HT concentration through pharmaceutics is associated with a change in blood pressure in the human and the rat.…”

Section: Circulating 5-ht Is Involved In Maintenance Of Blood Pressurmentioning

confidence: 99%

5-Hydroxtryptamine Receptors in Systemic Hypertension: An Arterial Focus

Watts

Davis

2011

Cardiovascular Therapeutics

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SUMMARYBackground: Serotonin (5-hydroxytryptamine [5-HT]) was named for its isolation from blood serum (sero-) and ability to contract smooth muscle (-tonin). Thus, its relationship with the cardiovascular system began with its discovery. Aims: This review will focus on the effects of 5-HT and its receptors in the vasculature, with a focus on their involvement in high blood pressure (hypertension). Two seemingly contradictory bodies of evidence exist that make it difficult to assign any one function to 5-HT in vascular control of blood pressure. Results: In vitro, 5-HT is an established vasoconstrictor, the effects of which are amplified in hypertension. By contrast, 5-HT (or its precursor 5-hydroxytryptophan) lowers blood pressure when given chronically in vivo. We will discuss ideas that might help us understand these differences, discuss relatively new pharmacology parameters (e.g. biased, inverse agonism) as they pertain to 5-HT receptors, and pose questions that are vital to answer so as to understand the role played by 5-HT in control of blood pressure, especially as it pertains to vascular function. Conclusions: Our goal is to understand if the actions of 5-HT in hypertension are physiologically and clinically relevant. The community understands 5-HT has complex cardiovascular effects, and clinical studies have proven equivocal in terms of the involvement of 5-HT. This article provides a balanced view of evidence/literature that illustrates involvement of 5-HT in hypertension as controversial. It contributes new pharmacological knowledge of 5-HT compounds, and poses timely questions as to how this field can move forward. The take home message is that the cardiovascular effects of 5-HT are markedly complex such that we have not yet answered the question of whether 5-HT is beneficial or detrimental to hypertension.

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Relevance of platelet serotonergic mechanisms in pregnancy induced hypertension

Cited by 16 publications

References 22 publications

Serum Levels of Lipids, Calcium and Magnesium in Women with Hypothyroidism and Cardiovascular Diseases

Serum Levels of Lipids, Calcium and Magnesium in Women with Hypothyroidism and Cardiovascular Diseases

Serotonin and Blood Pressure Regulation

5-Hydroxtryptamine Receptors in Systemic Hypertension: An Arterial Focus

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