Relevance of non-criteria antiphospholipid antibodies titers among patients with antiphospholipid syndrome and patients with systemic lupus erythematosus

Urrego-Callejas, Tomás; Hernández, Alejandro; Giraldo, Sebastián Ruiz; Frade‐Sosa, Beatriz; Vanegas-García, Adriana L.; Muñoz, Camilo; Rúa, Carolina; Botero, Julieta Duque; González, Luis Alonso; Vásquez, Gloría; Gómez-Puerta, José A.

doi:10.1016/j.reumae.2023.01.001

Cited by 1 publication

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“…Even though the hypothesis that the non-criteria aPL profile could represent a distinguishing mark between the primary and secondary APS patients was raised, further studies are necessary to confirm this possible role of non-classical aPLs [ 29 ]. Our results did not show any significant differences between the titres of non-criteria aPLs in primary and secondary APS.…”

Section: Discussionmentioning

confidence: 99%

Criteria and Non-Criteria Antiphospholipid Antibodies in Antiphospholipid Syndrome: How Strong Are They Correlated?

Caraiola,

Voicu,

Jurcut

et al. 2023

Biomedicines

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The place of non-criteria antiphospholipid antibodies (aPLs) in the diagnosis of antiphospholipid syndrome (APS) is still debatable. The aim of this research was to evaluate the correlations between the titres of non-criteria aPLs (anti-phosphatidylethanolamine (aPE), anti-phosphatidylserine (aPS), and anti-prothrombin (aPT) antibodies), and the ones of the already studied criteria aPLs (anti-cardiolipin (aCL) and anti-β2 glycoprotein I-aβ2GPI antibodies). Altogether, 72 APS (30 primary and 42 secondary) patients were included in our study. High correlation coefficients (rs) were found between aPS IgM and aCL IgM, overall (0.77, p < 0.01), as well as in the primary (0.81, p < 0.01), and secondary (0.75, p < 0.01) APS subgroups. Low or statistically insignificant correlations were observed between IgG/IgM isotypes of aPT and aCL, or aβ2GPI, in the entire study population, and when evaluating the subgroups. Therefore, moderate correlations were mainly identified between the tested non-criteria antibodies and the criteria ones, suggesting little added value for the use of the tested non-criteria aPLs, with the exception of aPT, which seems to have different kinetics and might be a promising APS diagnostic tool.

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Section: Discussionmentioning

confidence: 99%