Relevance of multicolor imaging in type 2 macular telangiectasia

Venkatesh, Ramesh; Pereira, Arpitha; Bavaharan, Bharathi; Jain, Kuldeep; Aseem, Aditya; Sangai, Sajjan; Yadav, Naresh Kumar

doi:10.4103/joco.joco_96_20

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…In this table, we summarized the observations of MCI and its advantages found in published papers. The list is not exhaustive; however, it highlights the salient features of different retinal and choroidal disorders [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Sanjay¹,

Kawali²,

Gopalakrishnan³

et al. 2022

Med Hypothesis Discov Innov Optom

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Background: Dengue fever is associated with various sight-threatening ocular manifestations, some of which can occur several months after fever. These include subconjunctival hemorrhage, vitreous hemorrhage, retinal hemorrhage, cotton wool spots, central and branch retinal artery occlusion, central scotoma, papilledema, optic neuropathy, retinal vasculitis, retinitis, retinal pigment epithelium mottling, foveolitis, choroidal effusion, exudative retinal detachment, anterior uveitis, endogenous endophthalmitis, and panophthalmitis. Herein, we report a patient with unilateral central retinal artery occlusion (CRAO) and raised dengue immunoglobulin G (IgG) titers who underwent serial multimodal imaging with fundus photography, spectral domain optical coherence tomography (SD-OCT), optical coherence tomography angiography (OCTA), and multi-color imaging (MCI). Furthermore, we reviewed recent publications highlighting different eye diseases and the role of MCI in their diagnosis and serial monitoring. Case presentation: A 53-year-old Asian Indian woman complained of blurring of vision in the right eye (OD) two months after a bout of fever. Her best-corrected distance visual acuity was finger counting close to the face in the OD and 20/40 in the left eye. CRAO of the OD was diagnosed. Systemic investigations were normal except for elevated dengue IgG levels. Optical coherence tomography and fluorescein angiography confirmed this diagnosis. MCI and SD-OCT using Spectralis™ performed before and after treatment with oral steroids demonstrated improvement. MCI served as a noninvasive ancillary tool for monitoring the CRAO. In addition to the case report, we summarize articles pertaining to MCI published during the years 2018–2022. The list is not exhaustive but highlights salient features of different retinal and choroidal disorders evaluated using MCI. Our summary highlights the role of MCI in the diagnosis and serial monitoring of eye diseases. Conclusions: A diagnosis of post-dengue fever retinal artery occlusion should be made after ruling out other causes of retinal artery vascular occlusion. We demonstrated retinal changes using serial imaging. MCI can be a useful tool, along with SD-OCT, to monitor clinical improvement. Optometrists can follow up patients with retinal vascular occlusions using noninvasive methods.

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Section: Discussionmentioning

confidence: 99%

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Sanjay¹,

Kawali²,

Gopalakrishnan³

et al. 2022

Med Hypothesis Discov Innov Optom

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“…A few recently published papers on MC imaging in type 2 MacTel have already established its valuable role in the disease diagnosis and identifying the exact extent of involvement and disease stage including the advanced stage of SRNVM. 12,13,19 The confocal blue reflectance using the 488 nm short wavelength light demonstrates increased reflectance in the parafoveal region in eyes with type 2 MacTel. 6,20,21 The area of hyper reflectance is usually slightly larger than the area of hyper fluorescence in late-phase fluorescein angiography or increased hyper autofluorescence seen on FAF, providing evidence that the disease process extends beyond the margins of the angiographically visible vascular alterations.…”

Section: Discussionmentioning

confidence: 99%

“…1,6 In such scenarios, the confocal infrared reflectance images identify the retinal hyperpigmented plaques as dark spots and the SRNVM as a well-defined area of hyper reflectance within the area of retinal telangiectasia. 13 These reasons make the MC colour fundus image as an extremely valuable tool in the diagnosis, identifying the disease stage, accurately recognising the extent of involvement and finally for assessing progression at various follow-up visits.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis was confirmed on the MC image based on the description provided in our previous publication on MC imaging in type 2 MacTel. 13 The confocal blue and green reflectance channels were used to identify the non-proliferative signs of type 2 MacTel like perifoveal greying and loss of retinal transparency, superficial retinal crystals and retinal pigment epithelial hyperplasia/plaques. Confocal infrared reflectance channel was used to identify the presence and extent of SRNVM.…”

Section: Methodsmentioning

confidence: 99%

“…A recently published paper by our group showed the MC imaging to be a useful non-invasive imaging technique to identify both early and late features in type 2 MacTel. 13 Features of the non-proliferative disease such as loss of retinal transparency, presence of superficial retinal crystals, right-angled vessels and retinal pigment epithelial plaques are identified on the blue and green reflectance channels. Presence of subretinal neovascular membrane suggestive of proliferative disease stage is noted on the infrared reflectance channel.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional relevance of macular telangiectasia (MacTel) area on multicolour imaging in type 2 MacTel

Venkatesh

Reddy

Agrawal

et al. 2021

European Journal of Ophthalmology

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Purpose: To analyse the correlation between area of macular telangiectasia (MacTel) involvement on multicolour (MC) imaging, disease stages and visual acuity in type 2 MacTel. Methods: In this retrospective analysis of MC images, confirmed cases of type 2 MacTel were graded into different disease stages as per Gass and Blodi and Yannuzzi et al classification systems. The ‘MacTel area’ was calculated by marking the outer boundary of an area with abnormally increased reflectivity to confocal blue wavelength light. At every follow-up visit, best-corrected visual acuity, MacTel area and stage of disease on the MC image was documented. Analyses between disease stage, MacTel area and visual acuity was carried out. Results: In total, 92 eyes of 49 patients were included in the study. The mean age was 59.6 ± 8.96 years. About 182 high-quality gradable MC images were available for analysis. There was a statistically significant difference in the visual acuity ( p < 0.001) and area of involvement ( p < 0.001) in the non-proliferative and proliferative type 2 MacTel groups. An increase in disease severity stage statistically correlated positively with Mactel area ( r = 0.544; p < 0.001) and logMAR visual acuity ( r = 0.329; p < 0.001). Over time, there was a significant increase in area of MacTel involvement ( p = 0.012) with an associated decrease in the visual acuity ( p = 0.023). Conclusion: The MacTel area measured on MC imaging showed a strong positive correlation with disease stage and a negative correlation with visual acuity. This could serve as a useful biomarker in clinical trials and understanding the natural history of the disease.

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The role of near-infrared reflectance imaging in retinal disease: A systematic review

Sukkarieh

Lejoyeux

LeMer

et al. 2023

Survey of Ophthalmology

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Relevance of multicolor imaging in type 2 macular telangiectasia

Cited by 9 publications

References 17 publications

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Functional relevance of macular telangiectasia (MacTel) area on multicolour imaging in type 2 MacTel

The role of near-infrared reflectance imaging in retinal disease: A systematic review

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