Relevance of Markers of Hemostasis Activation in Obstetrics/Gynecology and Pediatrics

Dati, Francesco; Pelzer, H.; Wagner, Carola

doi:10.1055/s-2007-996037

Cited by 19 publications

(10 citation statements)

References 30 publications

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“…This result supports the finding that both coagulation [23] and fibrinolysis [18] are activated during labor. In the study of Dati et al [24], all the markers of haemostasis activation were shown to be increased in the first 24 hr of healthy neonates. As TAFI is activated by thrombin, high levels of TAFIa may also indicate hypercoagulation.…”

Section: Discussionmentioning

confidence: 92%

Thrombin activatable fibrinolysis inhibitor activity, thrombin‐antithrombin complex and D‐dimer levels in preterm neonates with early respiratory distress syndrome

Gürsoy¹,

Tekinalp²,

Yurdakök³

et al. 2007

American J Hematol

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Intraalveolar fibrin deposition found in neonates with respiratory distress syndrome (RDS) is explained by the activation of the coagulation system and inefficient fibrinolysis. However, thrombin activatable fibrinolysis inhibitor activity (TAFIa), an inhibitor of fibrinolysis, and the ratio of D-dimer to thrombin-antithrombin complex (D-dimer/TAT), an index of fibrinolytic activity, have not been reported previously in neonatal RDS. Aim of this study is to evaluate the influence of plasma TAFIa levels on the fibrinolytic state in neonatal RDS. The RDS group (Group 1) consisted of 29 neonates, and 18 neonates served as the control group (Group 2). Plasma TAFIa levels and D-dimer/TAT ratios were evaluated in all neonates in the first 6 hr of life. Neonates in the RDS group were further divided into two subgroups; Group 1a consisted of 12 neonates with evidence of mild asphyxia (Apgar score at 5 min <7 and cord pH <7.26), and Group 1b consisted of 17 nonasphyxiated neonates. No significant difference was found in TAFIa levels and D-dimer/TAT ratios between Groups 1 and 2 [214% (56.2-361%) and 124.3 (4.4-3,921) in Group 1 and 201% (60.3-381%) and 147 (5.9-1,426) in Group 2]. There were negative correlations between cord pH and TAFIa levels in both groups. Increased TAFIa levels and decreased D-dimer/TAT ratios and platelet counts were detected in mildly asphyxiated neonates when compared with nonasphyxiated ones. TAFIa is not responsible for the hypofibrinolytic state reported in RDS. However, asphyxia influences TAFIa levels and increased TAFIa levels depress fibrinolysis. Am. J. Hematol. 83:50-53, 2008. V

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Section: Discussionmentioning

confidence: 92%

Thrombin activatable fibrinolysis inhibitor activity, thrombin‐antithrombin complex and D‐dimer levels in preterm neonates with early respiratory distress syndrome

Gürsoy¹,

Tekinalp²,

Yurdakök³

et al. 2007

American J Hematol

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“…As a novel anti-coagulation factor, the role of α 1 -AT in the regulation of physiological coagulation has been highlighted in the past several years. Recent studies show that α 1 -AT can bind to the activated protein C (APC) and inhibit the anticoagulation of APC [14]. In addition, α 1 -AT is also an inhibitor of coagulation factor XIa.…”

Section: Discussionmentioning

confidence: 99%

Alpha-1-Antitrypsin Acts as a Preeclampsia-Related Protein: A Proteomic Study

Feng

Zhou²,

Li³

et al. 2012

Gynecol Obstet Invest

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Aims: To screen the preeclampsia-related protein by proteomics. Methods: Proteomics was performed to identify differential protein expression profiles between normal full-term pregnancy, early-onset severe preeclampsia (ES-PE) or late-onset severe preeclampsia (LS-PE; n = 10 per group). Real-time quantitative PCR and immunohistochemistry were conducted to confirm the expression of α₁-antitrypsin (α₁-AT) in the decidual tissues of different subjects. ELISA was employed to detect the α₁-AT content in the peripheral blood of 90 women (n = 30 per group). Results: We successfully constructed two-dimensional electrophoresis maps of decidual tissues, and a total of 20 differentially expressed proteins were identified. The α₁-AT expression was different among the three groups. The normal full-term pregnancy women expressed the most α₁-AT, and the LS-PE women expressed the least amount of α₁-AT. The difference in the α₁-AT expression was consistent with the proteomics data. The peripheral α₁-AT content was the highest in the normal full-term pregnancy group (1.85 ± 0.15 g/l), moderate in the ES-PE group (0.77 ± 0.14 g/l) and lowest in the LS-PE group (0.42 ± 0.07 g/l; p < 0.05). Conclusion: Using 2D PAGE, we identified twenty proteins with significantly altered expression in PE. These differentially expressed proteins include prevention protein, in which α₁-AT is downregulated in PE.

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“…11 12 In pre-eclampsia, activation of coagulation, and fibrinolytic and platelet systems may alter the haemostatic balance at birth and predispose to intravascular coagulation. 13 The aims of our study were to determine the levels of the coagulation factors in premature infants at birth, and to assess the effects of gestational age and prenatal and perinatal events on the coagulation status.…”

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confidence: 99%

Effects of gestational age and prenatal and perinatal events on the coagulation status in premature infants

Salonvaara

2003

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Objective: To study prospectively the effects of prematurity and perinatal events on the coagulation status of premature infants. Patients and main outcome measures: Blood samples from premature infants born before 37 gestational weeks were taken for analysis of coagulation factors II, V, VII, and X and platelet count. Results: A total of 125 premature infants, 71 boys, were studied at the median postnatal age of 40 minutes (range 12-100). The lowest median activities of coagulation factors II, V, VII, and X and the platelet count were observed, as expected, in infants (n = 21) born at 24-27 weeks gestation. Twin B (n = 14) had lower median activities of coagulation factors II, V, VII, and X than twin A. Infants with evidence of mild asphyxia (Apgar score at 5 minutes < 7 or cord pH < 7.26) had significantly (p < 0.05) lower levels of coagulation factors II, V, VII, and X and platelet counts than infants without asphyxia. Infants who were small for gestational age (SGA) had significantly (p < 0.05) lower levels of coagulation factors V and VII and platelet counts than infants of appropriate size for gestational age. Other prenatal and perinatal variables examined (sex, maternal hypertension and/or pre-eclampsia, antenatal steroid use, mode of delivery, Apgar scores) did not show any significant associations with coagulation status, which may be explained by the small number of infants studied. Conclusions: The data strongly suggest that there are distinct differences in specific coagulation tests in different patient populations, which could assist in the identification of extremely preterm, SGA, or asphyxiated preterm infants who may be susceptible to haemorrhagic problems perinatally.

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Relevance of Markers of Hemostasis Activation in Obstetrics/Gynecology and Pediatrics

Cited by 19 publications

References 30 publications

Thrombin activatable fibrinolysis inhibitor activity, thrombin‐antithrombin complex and D‐dimer levels in preterm neonates with early respiratory distress syndrome

Thrombin activatable fibrinolysis inhibitor activity, thrombin‐antithrombin complex and D‐dimer levels in preterm neonates with early respiratory distress syndrome

Alpha-1-Antitrypsin Acts as a Preeclampsia-Related Protein: A Proteomic Study

Effects of gestational age and prenatal and perinatal events on the coagulation status in premature infants

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