Relevance of lactate level detection in migrane and fibromyalgia

Abstract

The aim of this study was to determine the blood lactate levels in healthy and pathological subjects, particularly with migraine and fibromyalgia. Moreover we investigated the possible correlation between lactate concentration, postural stability and balance disorders; the composition of the groups were: migraine (n = 25; age 49.7 ± 12.5), fibromyalgia (n = 10; age 43.7 ± 21.2), control group (n = 16 age 28.52 ± 2.4). The results showed that patients with fibromyalgia (FG) had higher lactate levels compared to migraine (MG) and control group (CG) (mean ± sd: FG = 1.78 ± 0.9 mmol/L; MG = 1.45±1 mmol/L; CG = 0,85 ± 0,07 mmol/L). The same situation was highlighted about the sway path length with eyes closed (FG = 518 ± 195 mm; MG = 465 ± 165 mm; CG = 405 ± 94,72 mm) and with eyes open (FG = 430 ± 220 mm; MG = 411 ± 143 mm; CG = 389 ± 107 mm). This can be explained by the fact that energy-intensive postural strategies must be used to optimize both static and dynamic coordination, in particular with repeated contractions of tonic oxidative muscle cells responsible for postural control.

The efficacy of alpha‐lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double‐blind, placebo‐controlled clinical trial

“…Mitochondrial dysfunction in migraine has been proven in previous studies 9‐11 . Due to the brain's requirement for high energy levels, it is particularly dependent on mitochondrial function.…”

The Role of Metabolism in Migraine Pathophysiology and Susceptibility

“…However, there are discrepancies between lactate measurements from different sample types. For instance, significantly higher lactic acid concentrations have been exhibited in blood, serum and plasma for migraine [87,88], but only serum for tension-type headache [88,89]. Increased lactate measurements may be indicative of cerebral hypoxia and shifts to anaerobic respiratory processes.…”

Fibromyalgia and Depression in Women: An 1H-NMR Metabolomic Study

“…Increased concentrations of citric acid ( Figure 3 and Figure S1 ), together with increased acetate and hypoxanthine levels—the AUCs of all these metabolites are 100%—are typical of a high incidence of anaerobic muscle metabolism [ 49 ]. This metabolic feature, also evident in the lactate transport dysmetabolism observed in Reactome analysis ( p -value: 0.005) ( Table 2 ), induces chronic fatigue and frequent migraines, the latter of which was an oft-cited complaint from the fibromyalgia patients [ 4 , 8 , 50 , 51 , 52 , 53 , 54 ].…”