Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation

Mărunţelu, Ion; Cristea, Bogdan; Omer, Secil; Preda, Carmen Monica; Constantinescu, Ileana

doi:10.1002/jcla.24075

Cited by 8 publications

(7 citation statements)

References 27 publications

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“…These results are in agreement with those of Noureen et al [26]. The HLA-A*11 allele was also positively associated with ESRD in a previous study performed by Maruntelu et al in the Romanian population [27]. However, the results of our study differed from those of Cao et al, who described an association between allele HLA*24 and ESRD [5].…”

Section: Discussionsupporting

confidence: 92%

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Iancu Loga,

Dican,

Chiorean

et al. 2023

IJMS

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End-stage renal disease (ESRD) is the final stage of chronic kidney disease. This study explored the association between human leukocyte antigen (HLA) and ESRD. The interaction between genetic and environmental factors may also play a role in the development of ESRD. The study included 2392 ESRD patients who were awaiting renal transplantation. Blood samples were genotyped by SSOP and SSP-PCR methods. Multivariate logistic regression analysis showed that HLA-A*11 (p = 0.027), HLA-A*34 (p = 0.017), HLA-A*69 (p = 0.012), HLA-B*41 (p < 0.001), HLA-B*50 (p = 0.004), HLA-DRB1*10 (p = 0.027), and HLA-DRB1*14 (p = 0.004) were positively associated with ESRD (OR > 1); HLA-DRB1*07 (p < 0.001), HLA-DRB1*08 (p = 0.005), and HLA-DRB1*13 (p < 0.001) were protective against ESRD (OR < 1); and the three-locus haplotype HLA-A*02–B*41–DRB1*03, containing one susceptible allele, was strongly associated with ESRD (p < 0.001, OR = 3.15). In conclusion, this retrospective analysis of HLA typing in patients with ESRD of various etiologies suggests that molecular data on the HLA polymorphism should be collected in order to identify high-risk ESRD patients and to improve graft survival after kidney transplantation.

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Section: Discussionsupporting

confidence: 92%

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Iancu Loga,

Dican,

Chiorean

et al. 2023

IJMS

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“…One of the first studies was carried out by Guja et al [ 53 ] who highlighted strong predisposing and protective associations of HLA-DQB1 in type 1 diabetes mellitus. Recently, our research group has identified HLA class I and II alleles that predispose patients to chronic renal failure [ 54 ] or increase the risk of developing hepatitis B [ 55 ]. In another work by Maruntelu et al [ 56 ], they also showed that the occurrence of celiac disease is closely associated to the HLA-DQA1*05:01, HLA-DQB1*02:01, and HLA-DQB1*02:02 allele expression in Romanian patients.…”

Section: Discussionmentioning

confidence: 99%

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

Tizu,

Calenic,

Maruntelu

et al. 2024

Medical Sciences

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Background and Objectives: The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most important genes involved in the occurrence and evolution of these pathologies are the HLA genes. The aim of this study is to analyze, for the first time, possible associations between chronic lymphoproliferative diseases and certain HLA alleles in the Romanian population. Materials and Methods: This study included 38 patients with chronic lymphoproliferative disorders, diagnosed between 2021 and 2022 at Fundeni Clinical Institute, Bucharest, Romania, and 50 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQB1/DPB1/DRB1) were investigated by doing high resolution genotyping using sequence specific primers (SSP). Results: Several HLA alleles were strongly associated with chronic lymphoproliferative disorders. The most important finding was that the HLA-C*02:02 (p = 0.002, OR = 1.101), and HLA-C*12:02 (p = 0.002, OR = 1.101) have a predisposing role in the development of chronic lymphoproliferative disorders. Moreover, we identified that HLA-A*11:01 (p = 0.01, OR = 0.16), HLA-B*35:02 (p = 0.037, OR = 0.94), HLA-B*81:01 (p = 0.037, OR = 0.94), HLA-C*07:02 (p = 0.036, OR = 0.34), HLA-DRB1*11:01 (p = 0.021, OR = 0.19), and HLA-DRB1*13:02 (p = 0.037, OR = 0.94), alleles have protective roles. Conclusions: Our study indicates that HLA-C*02:02 and HLA-C*12:02 are positively associated with chronic lymphoproliferative disorders for our Romanian patients while HLA-DRB1*11:01, HLA-DRB1*13:02, and HLA-B*35:02 alleles have a protective role against these diseases.

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“…Nevertheless, they identified a higher prevalence of protective alleles, which could explain the low incidence of this disease in the Romanian population. Recently, our team identified certain HLA class I and class II alleles with predisposing effects in patients with CRI [ 39 ]. Alleles such as HLA-B ∗ 40, HLA-C ∗ 12, and HLA-DRB1 ∗ 14 were found to be particularly predisposing to CRI in the Romanian population, in contrast to previous findings.…”

Section: Discussionmentioning

confidence: 99%

HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Tizu,

Calenic,

Hârza

et al. 2024

Genetics Research

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Background and Objectives. Numerous genome-wide association studies have highlighted that chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder with an important genetic component. An important number of genes have been implicated in CLL etiology, with some of the most important being human leukocyte antigen (HLA) genes. The aim of this study was to analyze the association of CLL with certain HLA alleles in the Romanian population and to compare our results with previous findings. Materials and Methods. This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology. Results. Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1∗04:02:01 (p=0.001, OR = 1.05) and HLA-DRB3∗02:01:01 (p=0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A∗24:02:01 0.01 (p=0.01, OR = 0.38), HLA-DQA1∗05:05:01 (p=0.01, OR = 0.56), HLA-DQB1∗03:02:01 (p=0.03, OR = 0.40), and HLA-DRB4∗01:03:01 (p=0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men. Conclusions. Our data are the first to indicate that in Romanian patients with CLL, the HLA-A∗24:02:01 and HLA-DQA1∗05:05:01 alleles have a protective role against CLL development, whereas HLA-DRB1∗04:02:01 and HLA-DRB3∗02:01:01alleles are positively associated with CLL.

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Relevance of HLA gene polymorphisms in Romanian patients with chronic renal insufficiency undergoing renal transplantation

Cited by 8 publications

References 27 publications

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

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