Relevance of FcγRIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients

Sugita, Noriko; Yamamoto, Kouji; Kobayashi, Tetsuo; Pol, W. Ludo van der; Horigome, Tuneyoshi; Yoshie, Hiromasa; Winkel, Jan G. J. van de; Hara, Kohji

doi:10.1046/j.1365-2249.1999.00984.x

Cited by 56 publications

(57 citation statements)

References 38 publications

(51 reference statements)

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“…Although in the literature there are studies suggesting the existence of a relationship between infectious disease attacks and FcγRIIIa and RIIIb polymorphisms [24][25][26], we could not confirm this relationship in this study. If this study is considered to be a preliminary study due to the low number of subjects, in a more comprehensive study, which could be carried out in Turkish population, the relationship between genetic polymorphism of the two different forms of the FcγRIII gene and infections may be established.…”

Section: Discussioncontrasting

confidence: 78%

Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases

et al. 2006

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The efficacy of IgG-induced Fc gamma receptor (FcgammaR) function displays interindividual heterogeneity due to genetic polymorphisms of three FcgammaR subclasses: FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb. FcgammaR polymorphisms may contribute to disease susceptibility or may alter disease course. The aim of this study is to examine FcgammaR gene polymorphisms in Turkish children with recurrent respiratory tract infections and without well known humoral immunodeficiencies. For the patients in the study group (n=52), recurrent infection was defined as the presence of at least six infection episodes a year. Seventy-one healthy children with a maximum of two infections in a year were enrolled as the control group. Subjects in both groups had no abnormalities in serum immunoglobulins, IgG subsets and specific antibody levels. For FcgammaRIIa: H131H, H131R, R131R genotypes and 131R, 131H alleles; for FcgammaRIIIa: F158F, F158V, V158V genotypes and 158F, 158V alleles; and for FcgammaRIIIb: -NA1/NA1, NA1/NA2, NA2/NA2 genotypes and NA1, NA2 alleles were determined by using amplification refractory mutation system polymerase chain reaction (ARMS-PCR). Compared with the control group, the FcgammaRIIa-R131R genotype and 131R allele were found to be significantly elevated in the study group, and FcgammaRIIa-H131H genotype and 131H allele in the study group were significantly lower than in the control group. Genotypes and alleles related with FcgammaRIIIa and FcgammaRIIIb gene polymorphisms did not show any significant difference between the study and control groups. FcgammaRIIa gene polymorphism (R131R) may increase the risk and susceptibility for recurrent infectious diseases in children.

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Section: Discussioncontrasting

confidence: 78%

Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases

et al. 2006

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“…16 The 158V genotype is associated with susceptibility to rheumatoid arthritis 17 and immune-mediated thrombocytopenic purpura, 18 better clinical response to rituximab in B-cell lymphomas 19,20 and a lower risk of recurrent periodontitis. 21 In contrast, systemic lupus erythematosus and better clinical outcome of cetuximab against metastatic colorectal cancer correlates with the 158F genotype. 22,23 This study analyzed the effect of donor and recipient SNP (rs396991) in the FCGR3A gene on the clinical outcomes in patients after allogeneic myeloablative BMT using an HLA allele-matched unrelated donor.…”

Section: Introductionmentioning

confidence: 99%

A single-nucleotide polymorphism of the Fcγ receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies

Takami

Espinoza

Onizuka

et al. 2010

Bone Marrow Transplant

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Fcc receptor type IIIA (FCGR3A) has a functional singlenucleotide polymorphism (rs396991), at which a G-to T-point mutation results in an amino acid substitution at position 158 (valine to phenylalanine; V158F). This study examined the effect of the FCGR3A polymorphism in donors and recipients on the clinical outcomes in unrelated HLA fully matched myeloablative BMT. The FCGR3A-V158F genotype was retrospectively analyzed in a total of 99 recipients with myeloid malignancies, and their unrelated donors. The presence of the 158V genotype in recipients showed a statistically better OS (adjusted hazard ratio (HR) 0.49; 95% confidence interval (CI) 0.26-0.93; P ¼ 0.03) and TRM (HR 0.30; 95% CI 0.14-0.67; P ¼ 0.003) without significant influence on the relapse rate. The recipient 158V genotype was also associated with a significantly reduced risk of chronic GVHD (HR 0.45; 95% CI 0.20-0.99; P ¼ 0.049) and a trend toward a reduced risk of grade II-IV acute GVHD (HR 0.55; 95% CI 0.27-1.10; P ¼ 0.09), leading to a significantly reduced GVHD-related mortality (HR 0.22; 95% CI 0.06-0.77; P ¼ 0.02). The donor FCGR3A polymorphism did not have any effect on the transplant outcomes. These results suggest an association between the recipient FCGR3A genotype and the clinical outcomes after BMT.

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“…In a Japanese patients, It was found that FcγRIIIa-158F allele was over represented in patients with periodontal disease recurrence. 27 In contrast, another Japanese researchers reported that the FcγRIIIa-158V allele was over-represented in patients with severe periodontitis versus subjects with moderate disease. 28 In this study, a significant association was observed between the FcγRIIIa-158V/F polymorphism and AgP patients.…”

Section: Distribution Of Fcγriii Genotypes and Allelesmentioning

confidence: 96%

The Fcγ receptor III genotype as a risk factor for aggressive periodontitis in Korean patients

Kim

Shin

Kim

et al. 2006

J Korean Acad Periodontol

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Relevance of FcγRIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients

Cited by 56 publications

References 38 publications

Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases

Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases

A single-nucleotide polymorphism of the Fcγ receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies

The Fcγ receptor III genotype as a risk factor for aggressive periodontitis in Korean patients

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