Relevance of autoimmune thyroiditis in children and adolescents with vitiligo

Uncu, Sibel; Yaylı, Savaş; Bahadır, Sevgi; Ökten, Ayşenur; Alpay, Köksal

doi:10.1111/j.1365-4632.2010.04665.x

Cited by 40 publications

(35 citation statements)

References 13 publications

(21 reference statements)

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“…Results of more recent studies on the association between vitiligo and disorders of the thyroid gland are reported in table 4 [6,7,9,10,12,16,17,18,23,24,28,33,34,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53]. Most surveys involving a control group showed a significant statistical difference in the prevalence of thyroid gland disorders between vitiligo patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

et al. 2014

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Background: Autoimmune comorbidities and circulating autoantibodies have been observed in vitiligo patients, but differences in rate are present according to countries in which the studies were performed, perhaps owing to ethnic diversities or different trigger factors. Objective: To estimate the prevalence of circulating autoantibodies and overt autoimmune diseases in a fairly large sample of Italian vitiligo patients. Methods: 175 outpatients affected by vitiligo and referred to nine dermatological centers were included in the study. Patients were offered routine blood test, serological testing for thyroid function and search for autoantibodies. Results: At least one circulating autoantibody was detected in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-thyroglobulin (23.4%), antinuclear antibodies (16.8%) and anti-gastric parietal cell antibodies (7.8%) were the most noticed autoantibodies. 74 (41.5%) autoimmune comorbidities, mainly autoimmune thyroiditis (37%), were reported. Conclusion: The prevalence of autoimmune comorbidities and circulating autoantibodies in this study was in agreement with other surveys conducted on Caucasian patients.

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Section: Discussionmentioning

confidence: 99%

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

et al. 2014

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“…Vitiligolu hastalarda da otoimmün hipotezi destekler nitelikte OPS tip 1, OPS tip 2, OPS tip3, OPS tip 4, otoimmün tiroidit, Graves hastalığı, Addison hastalığı, pernisiyöz anemi, myasitenia gravis, tip 1 diyabetus mellitus (juvenil), romatoid artrit, sistemik lupus eritematozis sık görülen otoimmün sistemik hastalıklardır [31][32] . Özellikle çalışmalarda tiroid hastalığı, otoimmün tiroidit ve tiroid otoantikorlarının vitiligolu hastalarda normal populasyona göre daha yüksek olduğu bildirilmiştir 31,[33][34][35] . AA'lı toplam 8 hastada (%15,7) tiroid otoantikorundan biri ya da her ikisinde pozitiflik tespit edildi.…”

Section: Discussionunclassified

Positivity of autologous serum skin test in patients with alopecia areata and vitiligo and in healthy individuals

Güven¹,

Gürler²,

Gündüz³

2015

TURKDERM

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Background and Design: Autologous serum skin test (ASST), the best in-vivo test displaying in vitro basophil histamin releasing activity, is used in the diagnosis of chronic autoimmune urticaria. Besides, it is cheap and is easy to perform. It has been found that in ASST-positive chronic urticaria patients, autoimmune thyroid disease especially and other autoimmune diseases were more common and the level of autoimmune markers were higher compared to others. Autoimmunity is accused in the pathogenesis of alopecia areata and vitiligo. In this study, we assessed ASST results in healthy controls and those with autoimmune diseases, and aimed to explore the effects of thyroid autoantibodies and other factors in ASST positivity. Materials and Methods: ASST was administered to 51 patients with alopecia areata, 53 patients with vitiligo and 51 healthy controls, and thyroid function tests and thyroid autoantibodies (anti-Tg, anti-TPO) were assessed. Results: ASST was positive in 64.7% of patients with in alopecia areata, 64.2% of those with vitiligo and in 45.1% of controls. There was no statistically significant difference between the groups in terms of ASST positivity. We observed that ASST positivity had no relationship with age, anti-Tg, anti-TPO and the presence of one or both autoantibody positivity. It was seen that the frequency of ASST positivity was higher in females than in men in all groups, but it was statistically significant in alopecia areata group only. Among the all study groups, the frequency of ASST positivity was statistically significantly higher in females than in men.

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“…7 The mean age of onset of vitiligo in our study is (8.45 ±3.42 yrs) which is in accordance with literature. 8,9 Although its exact inheritance pattern remains complex which is probably polygenic with variable penetrance and nearly 11% to 46% of the patients have other affected family member. 10,11 In our study family history of vitiligo was found in 36 (32.7%) patients.…”

Section: 7mentioning

confidence: 99%

A Study to Determine Prevalance of Thyroid Disorders in Children and Adolescents with Vitiligo

Dhanta¹

2017

jmscr

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Relevance of autoimmune thyroiditis in children and adolescents with vitiligo

Cited by 40 publications

References 13 publications

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

Positivity of autologous serum skin test in patients with alopecia areata and vitiligo and in healthy individuals

A Study to Determine Prevalance of Thyroid Disorders in Children and Adolescents with Vitiligo

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