Relevance of arginase in atopic diseases and potential mechanisms of association

Abstract

Atopic diseases have a high incidence all over the world, It affects about 25% of the global population, especially in developed countries and regions. At present, its incidence is still increasing year by year, which brings great pressure to the lives of patients and social economy. Arginase is an enzyme that catalyzes the hydrolysis of Larginine to ornithine and urea in human body and participates in a variety of physiological and pathological processes. Arginine metabolism is a key regulator of innate and adaptive immune responses. Study in atopic dermatitis (AD), (AS), atopic asthma rhinitis (AR) and allergic disease, the levels of arginase is closely related to the atopic diseases, this paper provides an overview of arginase biological function and role, analyses its in the blood, the airway and the role of mucous membrane of the skin, through a comprehensive review arginase applied in current clinical atopic disease research, to explore the relationship between arginase and the pathogenesis of atopic diseases, and to explore the potential role of arginase in the pathogenesis of atopic diseases, so as to provide a new plan for the treatment of allergic diseases.