Releasing profile of antibiotics from a novel mineralized collagen putty with quantifiable drug loading

Xie, B.-G.; Wang, X.-D.; Wang, H.; Hao, J.-H.; Qiu, Zhiye; Cui, Fengjuan; Xia, Mai; Liu, Y.-F.; Chen, X.-Y.

doi:10.1080/10667857.2015.1117200

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“…The mineralized collagen putty is provided as porous blocks, and is able to become paste form after being immersed in saline or blood and pinch for a about 2 minutes. Such paste is injectable and moldable, thus suitable for many orthopaedic applications, such as filling irregular bone defects, carrying drugs, gluing crushed bones for bone fractures, and so on [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Locking system strengthened by biomimetic mineralized collagen putty for the treatment of osteoporotic proximal humeral fractures

Peng

Wang

Yan

et al. 2017

Regenerative Biomaterials

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The current study is to observe the effect of the locking system strengthened by biomimetic mineralized collagen putty for the treatment of senile proximal humeral osteoporotic fractures. From January 2012 to December 2015, 80 cases of senile patients with osteoporotic proximal humeral fractures were randomly divided into an observation group and a control group, each group with a total of 40 cases. The control group was simply treated with locking plate. The observation group was treated with locking plate in combination with biomimetic mineralized collagen putty. The therapeutic effect thereby was observed. The excellent and satisfactory rate was 90% in observation group and was 72.5% in control group. The difference between the two groups was statistically significant (χ2 = 5.3312, P < 0.05). The fracture healing time was 11.82 ± 3.62 weeks in observation group and 19.78 ± 5.46 weeks in control group. The shoulder joint function score was 89.63 ± 8.12 in observation group and 76.92 ± 8.18 in control group. There was significant difference between the two groups (t = 7.1272; 12.7834, P < 0.05). The complication rate was 10% in the observation group and 32.5% in the control group (χ2 = 7.3786, P < 0.05). Locking system strengthened by biomimetic mineralized collagen putty has advantages such as accelerating healing of senile proximal humeral fracture, improving the therapeutic effect, reducing the complications. As one of the optimal internal fixation method, it provides a new option for better treatment of senile osteoporotic fracture.

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Section: Introductionmentioning

confidence: 99%