Releasing and structural/mechanical properties of nano-particle/Punica granatum (Pomegranate) in poly(lactic-co-glycolic) acid/fibrin as nano-composite scaffold

Gorji, Mona; Zargar, A.; Setayeshmehr, Mohsen; Ghasemi, Negin; Soleimani, Mitra; Kazemi, Mohammad Hossein; Hashemibeni, Batool

doi:10.4149/bll_2021_007

Cited by 2 publications

(3 citation statements)

References 41 publications

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“…To solve the issue, PLGA with a proper degradation period (3-6 months) can be a promising substance. PLGA is most widely used as a biomaterial for biomedical applications thanks to its superior biocompatibility and biodegradation properties, supporting cell attachment, anchorage, and proliferation [31] [32] [33]. The degradability of this copolymer results from its chemical aspects making its hydrolytic degradation possible [34].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of 3D-printed quaternary scaffolds containing polymeric matrix plus alginate nanoparticles and MWCNTs for cartilage tissue engineering

Pourmollaabbassi

Mahdavi

Shojaei

et al. 2023

Preprint

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Over the years, articular cartilage damage has impacted living standards world wide. Since each of the traditional therapeutic approaches has limitations, tissue engineering-based approaches have been recruited to provide a feasible solution. This study aimed to develop a novel nanocomposite 3D printed scaffold via a polymeric matrix accompanied with alginate nanoparticles and functionalized multi-walled carbon nanotubes (MWCNTs) to investigate its potential appropriateness for cartilage tissue engineering application. In this way, 3D printed constructs was developed by an extrusion-based printing method using the innovative nanocomposite inks consisting of PCL (polycaprolactone, P 35% w/v) and PLGA (poly (lactic-co-glycolic acid, P 15% w/v) incorporated with alginate nanoparticles (40 and 45% w/v), as a filler, and modified with or without MWCNTs (0.05 and 0.1% w/v), as a composite reinforcement. Next, the characterization of scaffold features was investigated. Results revealed that 3D printed scaffold containing PP/alginate45% with MWCNT0.05 (PPA45M0.05) had significant improvements in porosity (74.29%±7.33), water uptake, absorbance, cell attachment, hydrophilicity (64.15 ± 1.87), the compression modulus(0.2174MPa), and the degradation rate. In addition, the interaction within the whole constituents was validated by the spectra of ATR-FTIR. Due to the proper biodegradability, biocompatibility, and mechanical aspects, the PPA45M0.05 scaffolds would be a potential construct for cartilage tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Fabrication of 3D-printed quaternary scaffolds containing polymeric matrix plus alginate nanoparticles and MWCNTs for cartilage tissue engineering

Pourmollaabbassi

Mahdavi

Shojaei

et al. 2023

Preprint

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“…34,35 Recent studies have also investigated fibrin-loaded stem cells, such as bone marrow mononuclear cells and mesenchymal stem cells. 36–39…”

Section: Introductionmentioning

confidence: 99%

“…34,35 Recent studies have also investigated fibrin-loaded stem cells, such as bone marrow mononuclear cells and mesenchymal stem cells. [36][37][38][39] In this study, we aimed to design a cornea-like scaffold to facilitate transplantation for the treatment of corneal injury. Our scaffold is composed of readily accessible PFMs that are loaded with BMSCs and corneal epithelial cells (Fig.…”

Section: Introductionmentioning

confidence: 99%

Plasma fibrin membranes loaded with bone marrow mesenchymal stem cells and corneal epithelial cells promote corneal injury healing via attenuating inflammation and fibrosis after corneal burns

2023

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Releasing and structural/mechanical properties of nano-particle/Punica granatum (Pomegranate) in poly(lactic-co-glycolic) acid/fibrin as nano-composite scaffold

Cited by 2 publications

References 41 publications

Fabrication of 3D-printed quaternary scaffolds containing polymeric matrix plus alginate nanoparticles and MWCNTs for cartilage tissue engineering

Fabrication of 3D-printed quaternary scaffolds containing polymeric matrix plus alginate nanoparticles and MWCNTs for cartilage tissue engineering

Plasma fibrin membranes loaded with bone marrow mesenchymal stem cells and corneal epithelial cells promote corneal injury healing via attenuating inflammation and fibrosis after corneal burns

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