B Ensoli, L Buonaguro, G Barillari, V Fiorelli, R Gendelman, R A Morgan, P Wingfield, R C Gallo
Abstract:277 transactivator proteins of human retroviruses may mediate both viral and cellular effects. However, the events associated with the release, the uptake, and the biological effects of extracellular Tat are not yet well understood. In this study, we investigated whether during acute infection of T cells by HIV-1, Tat is released at concentrations sufficient to stimulate HIV-1 gene expression in a paracrine fashion and the events associated with the release of biologically active protein by cells transfected w…
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