Release of Warfarin from Human Serum Albumin by Water‐soluble CdSe Nanotetrapods

Abstract

Water soluble CdSe nanotetrapods are prepared by ligand exchange from organic‐soluble ones. In order to achieve this, oleic acid, which is the capping agent for as prepared water‐insoluble nanotetrapods, is exchanged with mercaptopropanoic acid (MPA). Shape and size of nanotetrapods are conserved upon ligand exchange. Ground state bleach recovery dynamics remain the same as well. However, they are completely non‐emissive. These water‐soluble nanotetrapods disrupt the secondary structure of Human Serum Albumin (HSA) and consequently, release warfarin bound to the protein.

Interplay of Multiexciton Relaxation and Carrier Trapping in Photoluminescent CdS Quantum Dots Prepared in Aqueous Medium

“…Predominant involvement of shallow traps is responsible for the significant PLQY, unlike many other water-soluble nanostructures rendered nonluminescent or weakly luminescent by deep traps. 8 The drastic decrease in PLQY for excitation above the band gap, ascribed to the competition from hot electron trapping, is a phenomenon that is, to the best of our knowledge, not reported earlier in aqueous QDs. Analysis of excitation fluence-dependent exciton dynamics allows for a deeper understanding of the underlying interwoven relaxation pathways and highlights the competitive kinetics involved.…”

“…4−6 Water-soluble QDs can be prepared in two ways: (i) synthesis in the organic phase followed by ligand exchange with hydrophilic capping agents or (ii) direct synthesis in an aqueous medium. 7,8 The second approach is more appealing, as it does not involve volatile organic solvents. The choice of the synthetic method greatly influences the inherent crystal quality and surface defects, which in turn govern optical properties.…”

Probe into the Molecular Mechanism of Ibuprofen Interaction with Warfarin Bound to Human Serum Albumin in Comparison to Ascorbic and Salicylic Acids: Allosteric Inhibition of Anticoagulant Release

“…Due to the high concentration of HSA in blood plasma and the high binding affinity to small molecules, many drugs are readily able to bind HSA, preventing their interactions with target proteins. , For example, warfarin, a major anticoagulant drug, has been found to bind HSA tightly, displaying a small rate of distribution throughout the body . One strategy to allow for HSA to release warfarin has been using other drugs that also have a high affinity for HSA. − These release-aided drugs are usually over-the-counter drugs that people can use along with their major medicines. Nevertheless, sometimes displacement of warfarin bound to HSA results in an increase in warfarin free concentration, which could then elevate the risk of bleeding .…”

Exciton Dynamics in Colloidal CdS Quantum Dots with Intense and Stokes Shifted Photoluminescence in a Single Decay Channel

“…45 On the one hand, water-soluble nanotetrapods, prepared by ligand exchange, are found to be nonemissive. 46 On the other hand, polyethylenimine (PEI)-capped CdS QDs, prepared in an aqueous medium, are found to exhibit a strong and long-lived trap emission, which is significantly Stokesshifted. 39 Selective PL quenching by Pb 2+ has been attributed to a combination of energetics of electron transfer and affinities of metal ions for the capping agent.…”

“…To this effect, weakly emissive CdSe nanotetrapods , have been doped with Cu + to obtain a dramatic enhancement in PL intensity and lifetime . On the one hand, water-soluble nanotetrapods, prepared by ligand exchange, are found to be nonemissive . On the other hand, polyethylenimine (PEI)-capped CdS QDs, prepared in an aqueous medium, are found to exhibit a strong and long-lived trap emission, which is significantly Stokes-shifted .…”