Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve

White, D. M.; Helme, R. D.

doi:10.1016/0304-3959(87)90139-4

Cited by 15 publications

(17 citation statements)

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“…The nerve fibres can also be seen to branch from the dermal fibres into the epithelium. Electrical stimulation of the sciatic nerve resulted in a significant increase in SP-like immunoreactivity in the perfusate of the subcutaneous space in the instep of the rat hind paw, as 11 shown in Figure 5, or in blister fluid of the rat hind paw, and this increase was abolished by neonatal pretreatment of rats with capsaicin (White & Helme, 1985). Treatment of newborn rats with capsaicin results in selective and permanent degeneration of small-diameter afferent fibres and significant decrease in the SP content (Jancso et al, 1980) and capsaicintreated animals show significantly increased latencies in response to a noxious thermal stimulus in either the tail-ffick or hot-plate test (Nagy et al, 1980).…”

Section: Effect Of Electrical Stimulation Of the Sciatic Nerve On Cutmentioning

confidence: 84%

“…SP immunofluorescent fibres in the skin were found in unmyelinated primary sensory neurones terminating around the small blood vessels in the dermis and epithelium. Moreover, electrical stimulation of the smalldiameter afferent fibres was shown to induce release of SP in the periphery (Olgart et al, 1977;White & Helme, 1985), and to produce the same cutaneous vasodilatation and plasma extravasation , as after intradermal or intra-arterial administration of SP (Hagermark et al, 1978;Lembeck & Holzer, 1979). These findings suggest that afferent impulses from nerve terminals of small-diameter afferent fibres generated by noxious stimuli may cause release of SP, which may finally control the inflammatory response through regulation of the microcirculation.…”

Section: Introductionmentioning

confidence: 82%

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Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

Yonehara

Chen

Imai

et al. 1992

British J Pharmacology

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1 The participation of small-diameter afferent fibres in the microcirculatory haemodynamics of cutaneous tissue was examined by studies on the effects of antidromic stimulation of primary afferent neurones on cutaneous blood flow (CBF) and tachykinin release into the subcutaneous space in the instep of the hind paw of rats. 2 Antidromic stimulation of the sectioned sciatic nerve induced a biphasic flow response, an initial transient decrease followed by an increase, with no alteration in the blood pressure. 3 Neither phase was affected by pretreatment with phentolamine (0.1 mg kg-', i.a.), propranolol (0.5 mg kg', i.a.), atropine (0.5 mg kg', i.a.), methysergide (0.5 mg kg', i.a.) or mepyramine (10mg kg-', i.a.) plus cimetidine (10 mg kg-', i.a.), but both were significantly inhibited by pretreatment with capsaicin (50mg kg-', s.c.).4 Spantide (1-2tgmolkg-', i.a.), a substance P (SP) antagonist, reduced the basal CBF, and also inhibited both phases of the biphasic flow response evoked by antidromic stimulation of the sectioned sciatic nerve. 5 Intra-arterial infusion of SP (0.5 Mmol kg-', i.a.) induced a biphasic flow response similar to that elicited by antidromic stimulation of the sectioned sciatic nerve. 6 Antidromic stimulation of the sectioned sciatic nerve caused a marked increase in SP release into the subcutaneous perfusate of the instep of the rat hind paw, but no detectable increase in neurokinin A release. 7 We suggest that SP and its receptors are mainly responsible for the vascular response induced by stimulation of the sectioned sciatic nerve, and that small-diameter afferent fibres containing SP tonically regulate vascular tone in cutaneous microvessels.

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Section: Effect Of Electrical Stimulation Of the Sciatic Nerve On Cutmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 82%

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

Yonehara

Chen

Imai

et al. 1992

British J Pharmacology

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“…Small-diameter primary afferent fibres not only transmit nociceptive messages to central neurons, but are also involved in inflammatory response, such as peripheral neurogenic inflammation (White and Helme, 1985). Following noxious stimulation, these fibres release substance P (SP) and calcitonin gene-related peptide (CGRP), related to oedema and plasma leakage (Basile et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: Role for cannabinoid receptors

et al. 2008

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Neuropathic pain consequent to peripheral nerve injury has been associated with local inflammation. Following noxious stimulation afferent fibres release substance P (SP) and calcitonin-gene related peptide (CGRP), which are closely related to oedema formation and plasma leakage. The effect of the anandamide transport blocker AM404 has been studied on plasma extravasation after chronic constriction injury (CCI) which consists in a unilateral loose ligation of the rat sciatic nerve (Bennett and Xie, 1988). AM404 (1e3e10 mg kg À1 ) reduced plasma extravasation in the legated paw, measured as mg of Evans Blue per gram of fresh tissue. A strong effect on vascular permeability was also produced by the synthetic cannabinoid agonist WIN 55,212-2 (0.1e0.3e1 mg kg À1). Using specific antagonists or enzyme inhibitors, we demonstrate that cannabinoids act at several levels: data on the 3rd day suggest a strong involvement of substance P (SP) and calcitonin gene-related peptide (CGRP) in the control of vascular tone, whereas at the 7th and 14th days the major role seems to be played by prostaglandins (PGs) and nitric oxide (NO). Capsaicin injection in ligated paws of AM404-or WIN 55,212-2-treated rats resulted in an increase of Evans Blue extravasation, suggesting the involvement of the cannabinergic system in the protective effect of C fibres of ligated paws. Taken together, these data demonstrate the efficacy of cannabinoids in controlling pain behaviour through the modulation of several pain mediators and markers of vascular reactivity, such as SP, CGRP, PGs and NO.

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“…However, it becomes Phe in substance P (SP; 11 amino acids), lie in eledoisin (11 amino acids) and Tyrin physalemin (11 amino acids) [1], Until now, three receptor subtypes of TKs have been identified: the NKi, NK.2 and NK3 inflammation is made highly apparent in ex periments where antidromic stimulation of sensory nerves produces inflammation of the innervated areas [6] by releasing neuropep tides, such as SP, NKA, the vasoactive intesti nal peptide (VIP) or the calcitonin generelated peptide (CGRP) [6][7][8]. These data are confirmed by the use of pharmacological tools such as capsaicin or resiniferatoxin [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Substance P and Sar9Met(O2)11-Substance P on Cutaneous Capillary Permeability in Guinea Pig Skin

Doutremepuich¹,

Barbier²,

Vilain³

et al. 1992

Skin Pharmacol Physiol

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The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar⁹Met(O₂)¹¹-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B₂-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar⁹Met(O₂)¹¹-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.

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Release of substance P from peripheral nerve terminals following electrical stimulation of the sciatic nerve

Cited by 15 publications

References 0 publications

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: Role for cannabinoid receptors

Effect of Substance P and Sar<sup>9</sup>Met(O<sub>2</sub>)<sup>11</sup>-Substance P on Cutaneous Capillary Permeability in Guinea Pig Skin

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