Release of renal renin in patients under long-term dailysis treatment.

Changes in Active and Inactive Renin with Haemodialysis

“…It was postulated that the rapid changes in body weight caused an exaggerated release of renin with a subsequent rise in blood pressure. Kaneda et al [3] performed a similar study on patients undergoing long-term dialysis and showed a significant correlation between the pre-dialysis PRA and change in PRA with removed sodium. Compari son between pre-dialysis PRA values of patients with essen tial hypertension and those on chronic haemodialysis [21] showed that many of the latter had higher PRA values than the essential hypertensive group.…”

“…They postulated that this was due to sodium and water being removed at each dia lysis, so that sodium balance as a whole was more negative in dialysis patients than in those with essential hypertension. Kaneda et al [3] demonstrated that younger patients on haemodialysis (age less than 29 years) had higher pre dialysis PRA levels than older dialysis patients, and specu lated that this might be a risk factor in hypertensive compli cations. Renin has, however, also been reported to decrease with age in essential hypertension [22].…”

“…Studies of plasma renin and its relationship to sodium balance and blood pressure in patients receiving mainten ance haemodialysis therapy have been performed by several workers [1][2][3]. Renin has been known to exist in multiple forms since 1953, when three types were differentiated by their ultra-violet absorption spectra [4], It was later shown that an inactive renin form exists in body fluids which can be activated by various pre-treatments.…”