Release of quercetin from micellar nanoparticles with saturated and unsaturated core forming polyesters — A combined computational and experimental study

Hassanzadeh, Salman; Khoee, Sepideh; Beheshti, Abolghasem; Hakkarainen, Minna

doi:10.1016/j.msec.2014.10.059

Cited by 5 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4] In the last two decades, the application of magnetic nanoparticles in clinical therapies, especially in the field of cancer diagnosis, has attracted much attention to many researchers owing to their magnetic and nanoscale specifications. [5][6][7][8] Among the magnetic nanoparticles, iron oxide (Fe 3 O 4 ) is one of the best candidates for drug delivery systems and biomedical applications due to its high biocompatibility and low toxicity. [9] MNPs can be considered effective nanocarriers for targeted delivery with the constant release of an anti-cancer drug and they can be conducted to a targeted site of the body by physical force from an external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

2023

View full text Add to dashboard Cite

In this research, a novel nanocarrier is synthesized based on tragacanth as a natural polysaccharide. For this purpose, carboxymethyl tragacanth (CMT) is first synthesized from tragacanth and then it is functionalized with isocyanate (IS) groups. In another parallel synthesis, magnetite nanoparticles (MNPs) are prepared by the co-precipitation method and coated with SiO 2 to form MNPs coated SiO 2 (MNPs@SiO 2 ). Then MNPs@SiO 2 is reacted with CMT-IS to form Fe 3 O 4 @SiO 2 /CMT. In the second step, the MNPs@SiO 2 /CMT surface is aminated by reaction with 3-amino propyl triethoxy silane (APTES) and then it is reacted with folic acid (FA) as a targeting agent to form MNPs@SiO 2 /CMT/FA nanocarrier. The synthesized nanocarrier is characterized by FT-IR, SEM, EDX, TEM, XRD, VSM, TGA, and zeta potential analysis and then it is loaded with doxorubicin (DOX) as a typical anti-cancer drug. The in vitro drug release studies are carried out from the DOX-loaded nanocarrier. The pH sensitivity of the DOX-loaded nanocarrier is examined attwo different pHs. The effect of DOX-loaded nanocarrier is investigated on MCF7 human breast cancer cells and the rate of cancer cell death is determined by MTT assay and drug IC50. The changes in the morphology of the tumor cell nuclei are observed using fluorescence microscopy.

show abstract