Release of polyionizable compounds from submicrometer oil‐in‐water emulsions

Silvestri, Shawn; Wu, Lailei; Bowser, Bill

doi:10.1002/jps.2600810504

Cited by 5 publications

(1 citation statement)

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“…Therefore, this behavior is only valid at specific pH, which suggests that pH measurements are the major tool to control this aspect of drug-containing nanoemulsion. 15 According to Floyd,16 the optimum pH of the finished nanoemulsion is in the general range of 6-7 and low pH (values lower than 5) should be avoided as the electrostatic repulsion between particles is decreased, resulting in an increased globule size and coalescence. In addiction, neutral pH minimizes lecithin hydrolysis.…”

Section: Discussionmentioning

confidence: 99%

Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Filippin¹,

Souza²,

Maranhão

2008

Quím. Nova

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Recebido em 16/5/07; aceito em 27/9/07; publicado na web em 2/4/08 Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.

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Section: Discussionmentioning

confidence: 99%

Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Filippin¹,

Souza²,

Maranhão

2008

Quím. Nova

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Stability of lipid emulsions for drug delivery

Washington

1996

Advanced Drug Delivery Reviews

163

112

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Minagawa

Kohno

Suwa

et al. 1994

Pharmaceutical Research

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Evaluation of entrapping efficiency is difficult for an o/w emulsion formulation containing a lipophilic oily drug, isocarbacyclin methyl ester (TEI-9090), by commonly employed techniques (dialysis, ultrafiltration, or gel filtration), because of its adsorption to the system materials. Employing this characteristic of TEI-9090, we developed an adsorption technique with polydimethylsiloxane-coated glass beads (PDMS-GB). The assay is based on the quantitative adsorption of unentrapped TEI-9090 to the PDMS-GB. The entrapping efficiency of a 10% soybean oil emulsion containing [3H]TEI-9090 (1 microgram/mL) assayed by this method approached 100%. The PDMS-GB assay was performed for the emulsion diluted 100 times with physiological saline at different time intervals after dilution over a period of 24 hr. A plot of [3H]TEI-9090 in the emulsion particles versus time showed rapid release within 1 hr, followed by very slow release, reaching equilibrium. Applying first-order kinetics, the data were found to fit to a biexponential equation over the first hour of release. The terminal release resembled the first-order release of the drug from the phospholipid-rich infranatant, which was separated from the creamy layer by ultracentrifugation of the emulsion and contained 35% [3H]TEI-9090. These results suggest that the drug is released from two components in the emulsion.

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Release of polyionizable compounds from submicrometer oil‐in‐water emulsions

Cited by 5 publications

References 0 publications

Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Stability of lipid emulsions for drug delivery

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