Release of MicroRNA‐Containing Vesicles Can Stimulate Angiogenesis and Metastasis in Renal Carcinoma

Collino, Federica; Grange, Cristina; Camussi, Giovanni

doi:10.1002/9781118300312.ch37

Cited by 1 publication

(1 citation statement)

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“…Multiple studies suggest that intercellular miRNA communication could play a role in cancer biology. For example, specific miRNA transport between IL-4-activated tumour-associated macrophages and breast cancer cells resulted in increased cell invasiveness 149 , and the release of miRNA-containing vesicles from renal cancer stem cells stimulated both angiogenesis and metastasis 150 , 151 . Furthermore, leukaemic cells were found to transfer miR-92 exosomally to endothelial cells resulting in their increased cellular migration 152 .…”

Section: Origin and Function Of Cell-free Nucleic Acidsmentioning

confidence: 99%

The circulating transcriptome as a source of non‐invasive cancer biomarkers: concepts and controversies of non‐coding and coding RNA in body fluids

Fernández-Mercado

Manterola

Larrea

et al. 2015

J Cellular Molecular Medi

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The gold standard for cancer diagnosis remains the histological examination of affected tissue, obtained either by surgical excision, or radiologically guided biopsy. Such procedures however are expensive, not without risk to the patient, and require consistent evaluation by expert pathologists. Consequently, the search for non-invasive tools for the diagnosis and management of cancer has led to great interest in the field of circulating nucleic acids in plasma and serum. An additional benefit of blood-based testing is the ability to carry out screening and repeat sampling on patients undergoing therapy, or monitoring disease progression allowing for the development of a personalized approach to cancer patient management. Despite having been discovered over 60 years ago, the clear clinical potential of circulating nucleic acids, with the notable exception of prenatal diagnostic testing, has yet to translate into the clinic. The recent discovery of non-coding (nc) RNA (in particular micro(mi)RNAs) in the blood has provided fresh impetuous for the field. In this review, we discuss the potential of the circulating transcriptome (coding and ncRNA), as novel cancer biomarkers, the controversy surrounding their origin and biology, and most importantly the hurdles that remain to be overcome if they are really to become part of future clinical practice.

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