Release of metal ions from nano CoCrMo wear debris generated from tribo-corrosion processes in artificial hip implants

Wang, Yang; Yan, Yu; Su, Yanjing; Qiao, Lijie

doi:10.1016/j.jmbbm.2017.01.041

Cited by 44 publications

(22 citation statements)

References 39 publications

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“…The toxicity of wear debris in vivo is a cumulative effect of all the different forms of debris that are generated. In addition, the toxicity of the organometallic species 154 generated in the synovial fluid may be unique (and possibly less toxic) than its ionic form. It was also reported that the albumin can enhance the dissolution of Co ions from wear debris.…”

Section: Current Limitations In Implant-based Toxicity Evaluation: Chmentioning

confidence: 99%

“…Many studies have shown that in vitro simulator testing is an accurate methodology to predict the performance of joint replacements. 154,156–158 Moreover, Catelas et al carried out a comparative evaluation of the physicochemical properties of wear particulate extracted from tissue samples of patients who underwent CoCrMo implant revision surgery in comparison to wear particles generated from the hip simulator. It was revealed that the particles generated in the simulator were comparable to those found in the periprosthetic patient samples with regards to the chemical composition, size and shape.…”

Section: Current Limitations In Implant-based Toxicity Evaluation: Chmentioning

confidence: 99%

See 1 more Smart Citation

Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches

Bijukumar

Segu

Souza

et al. 2018

Nanomedicine: Nanotechnology, Biology and Medicine

126

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Despite the technological improvements in orthopedic joint replacement implants, wear and corrosion products associated with the metal components of these implants may result in adverse local tissue and perhaps systemic reactions and toxicities. The current review encompasses a literature review of the local and systemic toxicity studies concerning the effect of CoCrMo wear debris released from wear and corrosion of orthopedic implants and prostheses. Release of metallic debris is mainly in the form of micro- and nano-particles, ions of different valences, and oxides composed of Co and Cr. Though these substances alter human biology, their direct effects of these substances on specific tissue types remain poorly understood. This may partially be the consequence of the multivariate research methodologies employed, leading to inconsistent reports. This review proposes the importance of developing new and more appropriate in-vitro methodologies to study the cellular responses and toxicity mediated by joint replacement wear debris in-vivo.

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Section: Current Limitations In Implant-based Toxicity Evaluation: Chmentioning

confidence: 99%

Section: Current Limitations In Implant-based Toxicity Evaluation: Chmentioning

confidence: 99%

Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches

Bijukumar

Segu

Souza

et al. 2018

Nanomedicine: Nanotechnology, Biology and Medicine

126

View full text Add to dashboard Cite

show abstract

“…Hence, in order to prepare processed particles (PDP), we have used high speed centrifugation to do multiple washing and further heat treatment to dry the particles which can partially mimic the commercial process. Many studies have proven that the in vitro simulator testing is an accurate method to predict the performance of the joint replacements (Barbour et al 1999, Leslie et al 2009, Hadley et al 2013, Wang et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells

et al. 2018

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Physico-chemical characteristics of the CoCrMo degradation products have played an important role in cytotoxicity and clinical complications on the orthopedic patients who have metal implants. Previous studies have limited reflection on the physicochemical characteristics of the degradation products generated in vivo, which are very different from individual metal particles and/or ions obtained from different commercial sources. In this study, we aimed to understand the differences in toxicity induced by the degradation products in as-synthesized form as well as those obtained after post-processing. The degradation products were generated using a hip-simulator by maintaining physiological conditions closer to in vivo and separated into two batches, one with processing by washing and drying called processed degradation products (PDP) and another batch as ‘as-synthesized’ degradation product (DP). We studied the dose-dependent toxicity response by neural cells derived from induced pluripotent stem cells. The results of the study show that as-synthesized DPs are more toxic to neural cells even at lower concentrations studied with evident low TC50 (1-5 μg/ml) concentrations compared to PDP (25 μg/ml). Flow cytometric analysis showed a significant (p<0.01) increase in uptake of the particles after 24h and corresponding ROS production in DP treated cells. RT-PCR analysis of oxidative specific gene expression showed, elevated mRNA levels of NADPH oxidase 1, nuclear transcription factor, Superoxide dismutase-2 and Glutaredoxin-2 in DP treated cells after 6h. The results of the study provided a clear evidence of the differential response of neural cells on the degradation products as a function of concentrations and their chemical nature.

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“…The shapes of the particles as depicted in Figure 9 , range from needle-like to spherical morphology with a size range of 25–50 nm. Contradictorily, Yan et al [ 86 ] tested nanosized wear debris of CoCrMo alloy in a protein containing bovine serum albumin (BSA) medium. It was observed in this study that the crystalline wear debris was comprised of two constituents instead of one, that is Cr oxide and the other being crystalline Co with a close-packed hexagonal (hcp) structure due to the transformation of fcc-Co to hcp-Co under significant plastic deformation during wear [ 87 ].…”

Section: Tribocorrosive Behavior Of Cocrmo Alloysmentioning

confidence: 99%

Tribochemical Characterization and Tribocorrosive Behavior of CoCrMo Alloys: A Review

et al. 2017

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Orthopedic implants first started out as an all-metal hip joint replacement. However, poor design and machinability as well as unsatisfactory surface finish subjected the all-metal joint replacement to being superseded by a polyethylene bearing. Continued improvement in manufacturing techniques together with the reality that polyethylene wear debris can cause hazardous reactions in the human body has brought about the revival of metal-on-metal (MOM) hip joints in recent years. This has also led to a relatively new research area that links tribology and corrosion together. This article aims at reviewing the commonly used tribochemical methods adopted in the analysis of tribocorrosion and putting forward some of the models and environmental factors affecting the tribocorrosive behavior of CoCrMo alloys, a widely-used class of biomaterial for orthopedic implants.

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Release of metal ions from nano CoCrMo wear debris generated from tribo-corrosion processes in artificial hip implants

Cited by 44 publications

References 39 publications

Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches

Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches

Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells

Tribochemical Characterization and Tribocorrosive Behavior of CoCrMo Alloys: A Review

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